Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

The Role of Chromatin during Transcription

2007 • 3,396 citations

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

2007 • 3,216 citations

Calcium - a life and death signal

1998 • 2,040 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

2005 • 1,704 citations

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

2006 • 1,625 citations

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

2002 • 1,485 citations

Molecular pathogenesis of human hepatocellular carcinoma

2002 • 1,424 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

2006 • 1,325 citations

Epigenetic stem cell signature in cancer

2006 • 1,083 citations

A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

2007 • 1,066 citations

CpG island methylator phenotype in cancer

2004 • 1,052 citations

A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements

2004 • 998 citations

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

2006 • 911 citations

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

2003 • 716 citations

Sensitive and quantitative universal Pyrosequencing™ methylation analysis of CpG sites

2003 • 494 citations

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.

1999 • 475 citations

CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.

1999 • 392 citations

Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas.

1991 • 385 citations

Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters

2007 • 365 citations

Aberrant CpG Island Hypermethylation Along Multistep Hepatocarcinogenesis

2003 • 329 citations

Aberrant Epigenetic Modifications in Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein

2007 • 299 citations

Predicting aberrant CpG island methylation

2003 • 283 citations

Wnt signalling: variety at the core

2007 • 270 citations

Genetic Instability and Aberrant DNA Methylation in Chronic Hepatitis and Cirrhosis—A Comprehensive Study of Loss of Heterozygosity and Microsatellite Instability at 39 Loci and DNA Hypermethylation on 8 CpG Islands in Microdissected Specimens From Patients With Hepatocellular Carcinoma

2000 • 269 citations

Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/β-catenin activity

2003 • 265 citations

Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia.

1998 • 260 citations

Pathway Mapping Tools for Analysis of High Content Data

2006 • 257 citations

Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma

2004 • 243 citations

Genome-wide hypomethylation in hepatocellular carcinogenesis.

2001 • 240 citations

Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island

2007 • 204 citations

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas

2007 • 200 citations

PTEN Gene and Integrin Signaling in Cancer

1999 • 186 citations

Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas.

2002 • 171 citations

High-throughput methylation profiling by MCA coupled to CpG island microarray

2007 • 161 citations

Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.

1999 • 151 citations

RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.

1998 • 148 citations

PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression

2003 • 140 citations

Detection of hypermethylation of the p16INK4A gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus

2001 • 136 citations

Optimizing Annealing Temperature Overcomes Bias in Bisulfite PCR Methylation Analysis

2007 • 126 citations

Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis

2000 • 113 citations

Bone morphogenetic protein 6 inhibit stress‐induced breast cancer cells apoptosis via both smad and P38 pathways

2007 • 37 citations

Long-term follow-up study of adenomatous hyperplasia in liver cirrhosis.

1994 • 24 citations