EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

2009 • 7,749 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

2007 • 5,137 citations

EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

2005 • 3,807 citations

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

2005 • 3,450 citations

A Tyrosine Kinase Created by Fusion of thePDGFRAandFIP1L1Genes as a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome

2003 • 1,683 citations

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

2004 • 1,231 citations

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

2005 • 556 citations

A mouse model for EML4-ALK -positive lung cancer

2008 • 498 citations

Identification of Novel Isoforms of theEML4-ALKTransforming Gene in Non–Small Cell Lung Cancer

2008 • 428 citations

A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient

2004 • 324 citations

Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC

2009 • 227 citations

Non‐solid oncogenes in solid tumors: EML4–ALK fusion genes in lung cancer

2008 • 216 citations

Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure: does the BCR-ABL mutation status really matter?

2009 • 196 citations

Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors

2010 • 158 citations

Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1

2009 • 137 citations

ALK Mutants in the Kinase Domain Exhibit Altered Kinase Activity and Differential Sensitivity to Small Molecule ALK Inhibitors

2009 • 36 citations

Identification of a constitutively active mutant of JAK3 by retroviral expression screening

2006 • 23 citations