Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

2008 • 33,782 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Cancer Statistics, 2008

2008 • 10,165 citations

Statistical significance for genomewide studies

2003 • 9,411 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

DAVID: Database for Annotation, Visualization, and Integrated Discovery

2003 • 8,668 citations

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

2004 • 5,895 citations

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

A Direct Approach to False Discovery Rates

2002 • 5,455 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer

2005 • 4,901 citations

The Epigenomics of Cancer

2007 • 4,239 citations

Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

2006 • 3,623 citations

Gene Silencing in Cancer in Association with Promoter Hypermethylation

2003 • 3,332 citations

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

2006 • 3,040 citations

Genes that mediate breast cancer metastasis to lung

2005 • 2,834 citations

The Genomic Landscapes of Human Breast and Colorectal Cancers

2007 • 2,716 citations

CpG island methylator phenotype in colorectal cancer

1999 • 2,476 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

2006 • 2,241 citations

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

2010 • 2,179 citations

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

2006 • 1,883 citations

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

2000 • 1,344 citations

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

2006 • 1,244 citations

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2002 • 1,231 citations

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

2006 • 1,144 citations

Genome remodelling in a basal-like breast cancer metastasis and xenograft

2010 • 1,138 citations

A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

2007 • 1,066 citations

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

2008 • 965 citations

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

2005 • 805 citations

Genetic determinants of cancer metastasis

2007 • 787 citations

DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

2008 • 567 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

2000 • 529 citations

Adjuvant Chemotherapy in Older and Younger Women With Lymph Node–Positive Breast Cancer

2005 • 404 citations

Lung metastasis genes couple breast tumor size and metastatic spread

2007 • 378 citations

PIK3CA Mutation Associates with Improved Outcome in Breast Cancer

2009 • 377 citations

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

2007 • 350 citations

Molecular Portraits and 70-Gene Prognosis Signature Are Preserved throughout the Metastatic Process of Breast Cancer

2005 • 328 citations

Statistical Significance of Clustering for High-Dimension, Low–Sample Size Data

2008 • 256 citations

Epigenetic silencing and deletion of the BRCA1gene in sporadic breast cancer

2006 • 236 citations

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

2010 • 167 citations

High-throughput methylation profiling by MCA coupled to CpG island microarray

2007 • 161 citations

Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis

2008 • 156 citations

Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake

2010 • 155 citations

Agglomerative Epigenetic Aberrations Are a Common Event in Human Breast Cancer

2008 • 152 citations

Molecular Concepts Analysis Links Tumors, Pathways, Mechanisms, and Drugs

2007 • 145 citations

LYN Is a Mediator of Epithelial-Mesenchymal Transition and a Target of Dasatinib in Breast Cancer

2010 • 142 citations

Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors

2006 • 137 citations

Hypermethylation in Histologically Distinct Classes of Breast Cancer

2004 • 114 citations

Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells

2007 • 111 citations

DNA hypermethylation of PITX2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients

2007 • 105 citations

Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma

2004 • 104 citations

Gene-Expression Profiles in Hereditary Breast Cancer

2001 • 100 citations

BRCA1 affects global DNA methylation through regulation of DNMT1

2010 • 96 citations

Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors

2003 • 86 citations

Epigenetic Inactivation of the Potential Tumor Suppressor Gene FOXF1 in Breast Cancer

2010 • 82 citations

DNA Hypermethylation ofESR1andPGRin Breast Cancer: Pathologic and Epidemiologic Associations

2009 • 67 citations

DNA Methylation as a Biomarker in Breast Cancer

2009 • 58 citations

The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer

2008 • 56 citations

Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation

2009 • 53 citations

Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients

2010 • 49 citations

DNA Methylation Profiles of Female Steroid Hormone-Driven Human Malignancies

2006 • 37 citations

Basal-like breast cancer displays distinct patterns of promoter methylation

2010 • 34 citations