Application of a BRAF Pyrosequencing Assay for Mutation Detection and Copy Number Analysis in Malignant Melanoma

Mutations of the BRAF gene in human cancer

2002 • 10,249 citations

A Gain-of-Function Mutation ofJAK2in Myeloproliferative Disorders

2005 • 3,402 citations

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

2004 • 2,674 citations

BRAF mutation predicts sensitivity to MEK inhibition

2005 • 1,312 citations

BRAF Mutation in Papillary Thyroid Carcinoma

2003 • 915 citations

Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma

2003 • 829 citations

Guilty as charged

2004 • 783 citations

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.

2001 • 634 citations

An Integrated View of Copy Number and Allelic Alterations in the Cancer Genome Using Single Nucleotide Polymorphism Arrays

2004 • 558 citations

Sensitive Sequencing Method for KRAS Mutation Detection by Pyrosequencing

2005 • 492 citations

Suppression of BRAF(V599E) in human melanoma abrogates transformation.

2003 • 412 citations

Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia.

2002 • 408 citations

BRAF Mutation Is Frequently Present in Sporadic Colorectal Cancer with Methylated hMLH1, But Not in Hereditary Nonpolyposis Colorectal Cancer

2004 • 404 citations

BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

2004 • 344 citations

V599EB-RAF is an Oncogene in Melanocytes

2004 • 343 citations

NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing

2006 • 310 citations

CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

2006 • 296 citations

What's going on 造血器腫瘍 A gain-of-function mutation of JAK2 in myeloproliferative disorders. Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC. N Engl J Med. 2005; 352: 1779-90. PMID:15858187.--慢性骨髄増殖性疾患においてJAK2遺伝子の変異が高頻度にみられることを示した論文

2005 • 263 citations

Detection of BRAF Mutation on Fine Needle Aspiration Biopsy Specimens: A New Diagnostic Tool for Papillary Thyroid Cancer

2004 • 254 citations

Promoter Hypermethylation Frequency and BRAF Mutations Distinguish Hereditary Non-Polyposis Colon Cancer from Sporadic MSI-H Colon Cancer

2002 • 201 citations

Absence of BRAF mutations in UV-protected mucosal melanomas

2004 • 180 citations

BRAF Is a Therapeutic Target in Aggressive Thyroid Carcinoma

2006 • 171 citations

JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders

2006 • 156 citations

BRAF as a potential therapeutic target in melanoma and other malignancies

2003 • 154 citations

Melanoma cell lines from different stages of progression and their biological and molecular analyses

1997 • 150 citations

Inhibitors of Raf Kinase Activity Block Growth of Thyroid Cancer Cells with RET/PTC or BRAF Mutations In vitro and In vivo

2006 • 142 citations

Inactivation of the Mitogen-Activated Protein Kinase Pathway as a Potential Target-Based Therapy in Ovarian Serous Tumors with KRAS or BRAF Mutations

2005 • 125 citations

High-Resolution Identification of Chromosomal Abnormalities Using Oligonucleotide Arrays Containing 116,204 SNPs

2005 • 109 citations

Raf kinases: Oncogenesis and drug discovery

2006 • 106 citations

BRAF and c-kit gene copy number in mutation-positive malignant melanoma

2006 • 98 citations

Real-time allele-specific amplification for sensitive detection of the BRAF mutation V600E

2004 • 96 citations

Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array

2004 • 93 citations

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines

2004 • 93 citations

<I>BRAF</I> Copy Number Gains in Thyroid Tumors Detected by Fluorescence <I>In Situ</I> Hybridization

2005 • 46 citations

Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction

2005 • 43 citations

Detection of BRAF mutations in colorectal tumours and peritoneal washings using a mismatch ligation assay

2005 • 6 citations

Deleted Work

1955 • 0 citations