Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

1982 • 1,790 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1996 • 1,489 citations

Cytokine signal transduction

1994 • 1,358 citations

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

1994 • 1,056 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

1987 • 906 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Wnt genes

1992 • 799 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

1997 • 725 citations

Dorsalizing signal Wnt-7a required for normal polarity of D–V and A–P axes of mouse limb

1995 • 719 citations

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

1996 • 663 citations

Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing center

1991 • 651 citations

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

1984 • 609 citations

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

1997 • 573 citations

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

1997 • 508 citations

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.

1991 • 502 citations

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1991 • 501 citations

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

1997 • 493 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

A frizzled homolog functions in a vertebrate Wnt signaling pathway

1996 • 471 citations

Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

1994 • 421 citations

Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

1994 • 384 citations

A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled

1996 • 369 citations

A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains

1989 • 367 citations

Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila

1987 • 351 citations

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

1995 • 321 citations

Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transduction.

1996 • 307 citations

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix.

1990 • 280 citations

Primary Structure and Tissue Distribution of FRZB, a Novel Protein Related to Drosophila Frizzled, Suggest a Role in Skeletal Morphogenesis

1996 • 243 citations

Swaying is a mutant allele of the proto-oncogene Wnt-1

1991 • 242 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Secreted int-1 protein is associated with the cell surface.

1990 • 215 citations

Overlapping Expression of Xwnt-3A and Xwnt-1 in Neural Tissue of Xenopus laevis Embryos

1993 • 202 citations

Wnt genes and vertebrate development

1994 • 173 citations

Identification of Three N-terminal Ends of Type XVIII Collagen Chains and Tissue-specific Differences in the Expression of the Corresponding Transcripts

1995 • 128 citations

Heparin Binding and Oligomerization of Hepatocyte Growth Factor/Scatter Factor Isoforms

1997 • 126 citations

Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.

1992 • 103 citations

Characterization of Novel Secreted and Membrane Proteins Isolated by the Signal Sequence Trap Method

1996 • 83 citations

Serpentine Proteins Slither into the Wingless and Hedgehog Fields

1996 • 74 citations

Regulation of Wnt5a mRNA Expression in Human Mammary Epithelial Cells by Cell Shape, Confluence, and Hepatocyte Growth Factor

1995 • 65 citations

Secretory and inductive properties of Drosophila wingless protein in Xenopus oocytes and embryos

1992 • 53 citations

Dissecting Wnt signalling pathways and Wnf-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis

1993 • 53 citations

int-1--a proto-oncogene involved in cell signalling.

1989 • 46 citations

A Human Homologue of the Drosophila Polarity Gene frizzled Has Been Identified and Mapped to 17q21.1

1995 • 45 citations

Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

1992 • 36 citations

Localization of the human cholecystokinin-B/gastrin receptor gene (CCKBR) to chromosome 11p15.5→p15.4 by fluorescence in situ hybridization

1994 • 33 citations

int-1 - a proto-oncogene involved in cell signalling

1989 • 8 citations

Secreted int-1 Protein Is Associated with the Cell Surface

1990 • 8 citations