CD11b+/Gr-1+ Immature Myeloid Cells Mediate Suppression of T Cells in Mice Bearing Tumors of IL-1β-Secreting Cells

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

IL-1 is required for tumor invasiveness and angiogenesis

2003 • 986 citations

Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species

2004 • 825 citations

Going both ways: Immune regulation via CD1d-dependent NKT cells

2004 • 801 citations

Going both ways: Immune regulation via CD1d-dependent NKT cells

2004 • 720 citations

The balance between IL-1 and IL-1Ra in disease

2002 • 694 citations

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

2002 • 657 citations

The IL-1 family and inflammatory diseases.

2004 • 597 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Blocking IL-1 in systemic inflammation

2005 • 497 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

Interleukin 1 is a radioprotector.

1986 • 386 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response

2004 • 334 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression

2004 • 312 citations

Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.

1987 • 309 citations

Immature myeloid cells and cancer-associated immune suppression

2002 • 304 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

NKT cells — conductors of tumor immunity?

2002 • 289 citations

Immunoregulatory T cells in tumor immunity

2004 • 257 citations

Interleukin-1—a major pleiotropic cytokine in tumor–host interactions

2002 • 214 citations

Alterations in T cell receptor and signal transduction molecules in melanoma patients.

1995 • 192 citations

Differential Effects of IL-1α and IL-1β on Tumorigenicity Patterns and Invasiveness

2003 • 162 citations

Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes

2000 • 155 citations

A Schistosome-Expressed Immunomodulatory Glycoconjugate Expands Peritoneal Gr1+ Macrophages That Suppress Naive CD4+ T Cell Proliferation Via an IFN-γ and Nitric Oxide-Dependent Mechanism

2001 • 151 citations

Down-regulation of ?-chain expression in T cells: a biomarker of prognosis in cancer?

2004 • 150 citations

Resection of Solid Tumors Reverses T Cell Defects and Restores Protective Immunity

2000 • 146 citations

Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells

1991 • 128 citations

Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells

2003 • 108 citations

A continuous delivery system of IL‐1 receptor antagonist reduces angiogenesis and inhibits tumor development

2003 • 97 citations

Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ

2000 • 93 citations

Reduced tumorigenicity of fibrosarcomas which constitutively generate il‐1α either spontaneously or following il‐1α gene transfer

1992 • 75 citations

Regulation of antitumour immunity by CD1d-restricted NKT cells

2004 • 63 citations

Antitumor and immunotherapeutic effects of activated invasive T lymphoma cells that display short-term interleukin 1alpha expression.

1999 • 56 citations

Different patterns of interleukin-1alpha and interleukin-1beta expression in organs of normal young and old mice.

2002 • 52 citations

Mechanisms of immune privilege for tumor cells by regulatory cytokines produced by innate and acquired immune cells

2002 • 41 citations

Cytokine-induced tumor immunogenicity: endogenous interleukin-1α expressed by fibrosarcoma cells confers reduced tumorigenicity

1993 • 39 citations

Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist [see comments]

1994 • 35 citations

Different regulatory levels are involved in the generation of hemopoietic cytokines (CSFs and IL-6) in fibroblasts stimulated by inflammatory products

1993 • 35 citations

Interleukin‐1 production by transformed fibroblasts. II. Influence on antigen presentation and T‐cell‐mediated anti‐tumor response

1992 • 31 citations

Interleukin‐1 produced by tumorigenic fibroblasts influences tumor rejection

1992 • 29 citations

Opposing effects of IL-1 alpha and IL-1 beta on malignancy patterns. Tumor cell-associated IL-1 alpha potentiates anti-tumor immune responses and tumor regression, whereas IL-1 beta potentiates invasiveness.

2000 • 29 citations

Opposing Effects of IL-1α and IL-1β on Malignancy Patterns

2006 • 26 citations

Vaccination with B16 melanoma cells expressing a secreted form of interleukin-1β induces tumor growth inhibition and an enhanced immunity against the wild-type B16 tumor

2000 • 22 citations

Distinct Patterns of IL-Lα and IL-Lβ Organ Distribution-A Possible Basis for Organ Mechanisms of Innate Immunity

2002 • 22 citations

Histogenesis and clonality of pancreatic tumors induced by v-myc and v-raf oncogenes in NFS/N mice.

1988 • 14 citations

Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells

1991 • 11 citations

Interleukin-1, stromal cells, granulopoiesis, and the inflammatory response

1989 • 7 citations

OPPOSING EFFECTS OF IL-l AND IL-1 ON MALIGNANCY PATTERNS Tumor cell-associated IL- I potentiates anti-tumor immune responses and tumor regression, whereas IL- 1 potentiates invasiveness

2000 • 6 citations