Distinct Patterns of IL-Lα and IL-Lβ Organ Distribution-A Possible Basis for Organ Mechanisms of Innate Immunity

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

J. Submicrosc. Cytol. Pathol.

2000 • 2,783 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein

1994 • 1,030 citations

IL-6 and APPs: anti-inflammatory and immunosuppressive mediators

1997 • 639 citations

Production of β-defensins by human airway epithelia

1998 • 574 citations

Human beta-defensin-2

1999 • 437 citations

Epithelial Antibiotics Induced at Sites of Inflammation

1995 • 417 citations

Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer

1990 • 399 citations

Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice

1995 • 365 citations

In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects.

1991 • 262 citations

Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment

1994 • 251 citations

Epithelial cells as regulators of airway inflammation

1998 • 234 citations

Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production.

1995 • 228 citations

Activation of neutrophils by recombinant interleukin 6

1989 • 222 citations

Interleukin 1 is present in normal human epidermis.

1986 • 214 citations

Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

1994 • 204 citations

Interleukin 1 is an autocrine regulator of human endothelial cell growth.

1990 • 197 citations

Interleukin-1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture.

1995 • 193 citations

PseudomonasPyocyanin Increases Interleukin-8 Expression by Human Airway Epithelial Cells

1998 • 191 citations

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

1996 • 190 citations

Mouse islet cell lysis mediated by interleukin-1-induced Fas

1996 • 187 citations

Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.

1996 • 185 citations

IL-1 and its receptor are translocated to the nucleus.

1990 • 172 citations

The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta.

1998 • 157 citations

Identification of a nuclear localization sequence within the structure of the human interleukin-1 alpha precursor.

1993 • 154 citations

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

1997 • 150 citations

Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells.

1994 • 134 citations

Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts.

1992 • 131 citations

The immunobiology of bile and biliary epithelium

1999 • 125 citations

The IL-1β-Converting Enzyme (Caspase-1) Inhibits Apoptosis of Inflammatory Neutrophils Through Activation of IL-1β

1998 • 121 citations

Detection of IL-1 alpha and IL-1 beta gene expression by in situ hybridization. Tissue localization of IL-1 mRNA in the normal C57BL/6 mouse.

1988 • 120 citations

Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression.

1990 • 109 citations

Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion

1997 • 109 citations

Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblats

1990 • 109 citations

Neutralization of interleukin-1 beta activity in vivo with a monoclonal antibody alleviates collagen-induced arthritis in DBA/1 mice and prevents the associated acute-phase response.

1993 • 106 citations

Modulation of rat mast cell reactivity by IL-1 beta. Divergent effects on nitric oxide and platelet-activating factor release.

1993 • 95 citations

Cytokine gene expression in the MRL/lpr model of lupus nephritis

1996 • 86 citations

Detection of interleukin 1 alpha and 1 beta in rabbit tissues during endotoxemia using sensitive radioimmunoassays

1991 • 78 citations

Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2

1997 • 74 citations

Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production

1995 • 69 citations

Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.

1996 • 67 citations

Biological activity and receptor binding of human prointerleukin-1 beta and subpeptides.

1988 • 66 citations

Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity

1989 • 66 citations

Interleukin-1 Protects Transformed Keratinocytes from Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95-induced Apoptosis but Not from Ultraviolet Radiation-induced Apoptosis

1999 • 63 citations

C-reactive protein protects against preerythrocytic stages of malaria

1989 • 57 citations

Activation of human natural killer cells by lipopolysaccharide and generation of interleukin-1 alpha, beta, tumour necrosis factor and interleukin-6. Effect of IL-1 receptor antagonist.

1991 • 46 citations

Detection of interleukin and interleukin-receptor mRNA in human heart by polymerase chain reaction

1991 • 44 citations

Ciliary Neurotrophic Factor (CNTF) Induces Serum Amyloid A, Hypoglycaemia and Anorexia, and Potentiates IL-1 Induced Corticosterone and IL-6 Production in Mice

1995 • 43 citations

TNF-alpha and IL-1 alpha induce mannose receptors and apoptosis in glomerular mesangial but not endothelial cells

1996 • 43 citations

Binding of C-reactive protein to the pneumococcal capsule or cell wall results in differential localization of C3 and stimulation of phagocytosis.

1984 • 42 citations

FAS Antigen Expression on Synovial Cells Was Down-Regulated by Interleukin 1β

1996 • 35 citations

Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra

1999 • 32 citations

Hepatic sinusoidal endothelium heterogeneity with respect to mannose receptor activity is interleukin-1 dependent

1996 • 31 citations

Interleukin-1 alpha mediates an alternative pathway for the antiproliferative action of poly(I.C) on human endothelial cells.

1992 • 31 citations

IL-1 and IL-1 receptor antagonist regulation during keratinocyte cell cycle and differentiation in normal and psoriatic epidermis

1998 • 30 citations

Complementary organ expression of IL-1 vs. IL-6 and CSF-1 activities in normal and LPS-injected mice

1996 • 29 citations

Hepatic sinusoidal endothelium heterogeneity with respect to mannose receptor activity is interleukin-1 dependent

1996 • 27 citations

Stimulation of arachidonic acid metabolism: Differences in potencies of recombinant human interleukin-1α and interleukin-1β on two cell types

1986 • 27 citations

Apoptosis and differentiation in the crypt-villus unit of the rat small intestine.

1999 • 25 citations

The expression of cytokines in the organs of normal individuals: role in homeostasis. A review.

1988 • 21 citations

The Role of Interleukin-1 in Interactive Senescence and Age-Related Human Endometrial Cancer

1999 • 18 citations

Preferential Production of Interleukin‐1β over Interleukin‐1 Receptor Antagonist Contributes to Proliferation and Suppression of Apoptosis in Leukemic Cells

1995 • 16 citations

Interleukin-1α, interleukin 6 and tumor necrosis factor α increase the synthesis and expression of the functional alternative and terminal complement pathways by human umbilical vein endothelial cellsin vitro

1996 • 15 citations

Interleukin-1alpha regulates G1 cell cycle progression and arrest in thyroid carcinoma cell lines NIM1 and NPA

1999 • 14 citations

Differential Regulation of Epidermal Cell Tumor-Antigen Presentation by IL-1α and IL-1β

1998 • 12 citations

C-reactive protein reduces the promotion of human B-cell colony formation by autoreactive T4 cells and T-cell proliferation during the autologous mixed-lymphocyte reaction

1986 • 10 citations

Interleukin-1β suppresses apoptosis in CD34 positive bone marrow cells through activation of the type I IL-1 receptor

1996 • 10 citations

Il-1β Transduces Different Signals than IL-1α Leading to Class II Antigen Expression on β-Insulinoma Rin-5AH Cells through Specific Receptors

1997 • 8 citations

Interleukin-1 alpha-induced modulation of topoisomerase I activity and DNA damage: implications in the mechanisms of synergy with camptothecins in vitro and in vivo.

1996 • 7 citations

A short synthetic peptide fragment of human interleukin-1 beta increases both human and murine natural killer activity.

1989 • 4 citations

In situ Hybridization for the Detection of Feline Interleukin 1.ALPHA. mRNA on the Paraffin-Embeddeb Section using Biotin-Labeled Probes.

1991 • 3 citations