Interleukin‐1 production by transformed fibroblasts. II. Influence on antigen presentation and T‐cell‐mediated anti‐tumor response

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

Plaque Formation in Agar by Single Antibody-Producing Cells

1963 • 2,385 citations

"Panning" for lymphocytes: a method for cell selection.

1978 • 1,319 citations

Antitrinitrophenyl (TNP) Plaque Assay. Primary Response of Balb/c Mice to Soluble and Particulate Immunogen

1969 • 935 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

1975 • 758 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

Interleukin l and T Cell Activation

1982 • 622 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2.

1984 • 529 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection

1985 • 410 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Limiting Dilution Analysis of Cells in the Immune System

1979 • 384 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Structure of the gene of tum− transplantation antigen P91A: The mutated exon encodes a peptide recognized with Ld by cytolytic T cells

1989 • 296 citations

Exogenous expression of mouse interferon gamma cDNA in mouse neuroblastoma C1300 cells results in reduced tumorigenicity by augmented anti-tumor immunity.

1989 • 284 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.

1978 • 268 citations

Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression.

1985 • 264 citations

Inducible interleukin-1 gene expression in human vascular smooth muscle cells.

1986 • 256 citations

Antigen presenting function of class II MHC expressing pancreatic beta cells

1988 • 255 citations

Interleukin 1 production by human polymorphonuclear neutrophils.

1986 • 205 citations

Induction of membrane-associated interleukin 1 by tumor necrosis factor in human fibroblasts.

1987 • 174 citations

Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts.

1987 • 171 citations

INTERLEUKIN-6 AND ITS RECEPTOR

2001 • 145 citations

Production of interleukin 1 activity by normal human peripheral blood B lymphocytes.

1985 • 138 citations

Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells.

1986 • 133 citations

Expression of passively transferred immunity against an established tumor depends on generation of cytolytic T cells in recipient. Inhibition by suppressor T cells.

1983 • 123 citations

Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.

1979 • 122 citations

Recombinant interleukin 2 as an adjuvant for vaccine-induced protection. Immunization of guinea pigs with herpes simplex virus subunit vaccines.

1988 • 114 citations

Effect of interleukin 1 on human thymocytes and purified human T cells.

1981 • 112 citations

Interleukin-3 and its receptor

1995 • 94 citations

In vitro production of interleukin 1 by normal and malignant human B lymphocytes.

1986 • 90 citations

The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1.

1988 • 81 citations

Antigen presentation ¹

1989 • 78 citations

Induction of human interleukin 1 mRNA measured by collagenase‐ and prostaglandin E₂‐stimulating activity in rheumatoid synovial cells

1984 • 59 citations

Interleukin 1 as an adjuvant for active specific immunotherapy in a murine tumor model.

1990 • 55 citations

Antigenic specificity of the cytolytic T lymphocyte (CTL) response to murine sarcoma virus-induced tumors. II. Analysis of the clonal progeny of CTL precursors stimulated in vitro with syngeneic tumor cells.

1980 • 54 citations

Production of interleukin 1 by adult T cell leukemia (ATL) cell lines.

1987 • 47 citations

Regulation of interleukin 1 generation in immune‐activated fibroblasts

1990 • 37 citations

Production of IL-1α and IL-1β by clones of EBV transformed, human B cells

1987 • 32 citations

Effect of continuous administration of interleukin 2 on active specific chemoimmunotherapy with extracted tumor-specific transplantation antigen and cyclophosphamide.

1988 • 27 citations

Antigen presentation, antigen-presenting cells and antigen processing

1988 • 24 citations

Global or directed exocytosis?

1988 • 17 citations

Limiting dilution analysis of the frequencies of helper and suppressor T cells in untreated and TNP-treated BALB/c mice: response as a consequence of perturbation of a stable steady state.

1985 • 16 citations

Technological advances in vaccine development

1988 • 15 citations

Cytotoxic T lymphocyte responses to spontaneous tumors: immunogenicity dependent on the recognition of processed tumor antigens.

1983 • 13 citations

Cytotoxic t‐cell precursors against non‐immunogenic rat tumors: Limiting dilution analysis

1986 • 4 citations