Activation, Differentiation, and Migration of Naive Virus-Specific CD8+ T Cells during Pulmonary Influenza Virus Infection

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 • 835 citations

CD8+ T Cell Effector Mechanisms in Resistance to Infection

2000 • 725 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

In Vivo Activation of Antigen-Specific CD4 T Cells

2001 • 498 citations

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

1997 • 493 citations

Early Programming of T Cell Populations Responding to Bacterial Infection

2000 • 492 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

1998 • 469 citations

Antigen presentation to naive CD4 T cells in the lymph node

2003 • 467 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

Cutting Edge: Rapid In Vivo Killing by Memory CD8 T Cells

2003 • 442 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

CD8 T Cell Responses to Infectious Pathogens

2003 • 433 citations

Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge.

1992 • 381 citations

Leukocyte Migration and Adhesion

1995 • 365 citations

Accelerated Migration of Respiratory Dendritic Cells to the Regional Lymph Nodes Is Limited to the Early Phase of Pulmonary Infection

2003 • 362 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

CD4 Effector T Cell Subsets in the Response to Influenza

2002 • 328 citations

Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing.

1988 • 302 citations

Measuring the diaspora for virus-specific CD8⁺T cells

2001 • 288 citations

Accessing Complexity: The Dynamics of Virus-Specific T Cell Responses

2000 • 283 citations

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice.

1996 • 276 citations

Dynamics and Requirements of T Cell Clonal Expansion In Vivo at the Single-Cell Level: Effector Function Is Linked to Proliferative Capacity

1999 • 253 citations

Human T cell activation. III. Rapid induction of a phosphorylated 28 kD/32 kD disulfide-linked early activation antigen (EA 1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens, and antigens.

1986 • 250 citations

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity

1998 • 248 citations

Down-regulation of homing receptors after T cell activation.

1988 • 235 citations

Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.

1989 • 226 citations

Phenotypic and Functional Analysis of Cd8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen

2001 • 220 citations

Metalloproteinase-mediated Regulation of L-selectin Levels on Leucocytes

1996 • 212 citations

The Strategy of T Cell Antigen-presenting Cell Encounter in Antigen-draining Lymph Nodes Revealed by Imaging of Initial T Cell Activation

2003 • 205 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

1998 • 179 citations

Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens

1999 • 174 citations

Control of lymphocyte homing

1994 • 170 citations

Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia.

1993 • 150 citations

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1998 • 144 citations

The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex.

1994 • 135 citations

Uncoupling of Proliferative Potential and Gain of Effector Function by CD8+ T Cells Responding to Self-Antigens

2002 • 131 citations

Swift Development of Protective Effector Functions in Naive Cd8+ T Cells against Malaria Liver Stages

2001 • 130 citations

Production of Interferon-γ by Influenza Hemagglutinin-Specific CD8 Effector T Cells Influences the Development of Pulmonary Immunopathology

2001 • 122 citations

Functional characterization of an antigen involved in an early step of T-cell activation.

1987 • 120 citations

Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice

1995 • 118 citations

T cell immunity in lymphoid and non-lymphoid tissues

2002 • 117 citations

Influenza virus RNA in the lung and lymphoid tissue of immunologically intact and CD4-depleted mice

1991 • 115 citations

Activation induces rapid and profound alterations in the trafficking of T cells

2000 • 112 citations

Cutting Edge: Rapid In Vivo CTL Activity by Polyoma Virus-Specific Effector and Memory CD8+ T Cells

2003 • 105 citations

Functional Flexibility in T Cells

2000 • 93 citations

Up-Regulation of VCAM-1 and Differential Expansion of β Integrin-Expressing T Lymphocytes Are Associated with Immunity to PulmonaryMycobacterium tuberculosisInfection

2000 • 89 citations

Memory CD8+ T Cells Undergo Peripheral Tolerance

2002 • 84 citations

LFA-1 is required for retention of effector CD8 T cells in mouse lungs

2003 • 77 citations

Cell Division Is Not a “Clock” Measuring Acquisition of Competence to Produce IFN-γ or IL-4

2001 • 74 citations

Functionally distinct T cells in three compartments of the respiratory tract after influenza virus infection

1996 • 54 citations

Distinct Thresholds for CD8 T Cell Activation Lead to Functional Heterogeneity: CD8 T Cell Priming Can Occur Independently of Cell Division

2003 • 53 citations

Endothelial selectins and alpha4 integrins regulate independent pathways of T lymphocyte recruitment in the pulmonary immune response.

1998 • 53 citations

Endothelial Selectins and α4 Integrins Regulate Independent Pathways of T Lymphocyte Recruitment in the Pulmonary Immune Response

1998 • 45 citations

Adherence of adoptively transferred alloreactive Th1 cells in lung: partial dependence on LFA-1 and ICAM-1

2000 • 25 citations

The Contributions of Integrins to Leukocyte Infiltration in Inflamed Tissues

1993 • 13 citations