Integrins as mechanochemical transducers

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Fibroblast traction as a mechanism for collagen morphogenesis

1981 • 862 citations

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro.

1990 • 851 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Topographical control of cell behaviour: II. multiple grooved substrata

1990 • 675 citations

Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate

1987 • 624 citations

Fibronectin controls capillary endothelial cell growth by modulating cell shape.

1990 • 498 citations

Calcium Mobilization and Exocytosis After One Mechanical Stretch of Lung Epithelial Cells

1990 • 494 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes.

1990 • 462 citations

Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface

1990 • 446 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.

1989 • 416 citations

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.

1991 • 368 citations

Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction.

1990 • 363 citations

Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.

1991 • 357 citations

Expression of extracellular matrix components is regulated by substratum.

1990 • 345 citations

Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells.

1990 • 316 citations

Fibroblast contractility and actin organization are stimulated by microtubule inhibitors

1989 • 303 citations

The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.

1990 • 288 citations

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.

1990 • 282 citations

Tissue plasminogen activator messenger RNA levels increase in cultured human endothelial cells exposed to laminar shear stress

1990 • 276 citations

Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family.

1991 • 259 citations

Mechanical transduction in biological systems.

1988 • 255 citations

Presence of an SH2 Domain in the Actin-Binding Protein Tensin

1991 • 248 citations

Control of intracellular pH and growth by fibronectin in capillary endothelial cells.

1990 • 241 citations

Stress relaxation of contracted collagen gels: Disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis

1991 • 217 citations

Shear stress increases inositol trisphosphate levels in human endothelial cells

1990 • 215 citations

A role for integrin in the formation of sarcomeric cytoarchitecture

1990 • 207 citations

Gene Expression During Normal and Malignant Differentiation

1986 • 157 citations

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

1990 • 155 citations

The Sensation and Regulation of Interactions with the Extracellular Environment: The Cell Biology of Lymphocyte Adhesion Receptors

1990 • 151 citations

The effect of fluid shear stress upon cell adhesion to fibronectin‐treated surfaces

1990 • 143 citations

Mechanics of fibroblast locomotion: quantitative analysis of forces and motions at the leading lamellas of fibroblasts.

1990 • 122 citations

Expression of the differentiated phenotype by epithelial cells in vitro is regulated by both biochemistry and mechanics of the substratum

1989 • 116 citations

Cell/substratum adhesions in RSV-transformed rat fibroblasts

1991 • 99 citations

In Defense of “Nonmolecular” Cell Biology

1990 • 94 citations

Tension as a regulator and integrator of axonal growth

1990 • 94 citations

Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets

1991 • 92 citations

Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.

1990 • 87 citations

Structural basis for mechanical transduction in the frog vestibular sensory apparatus: I. The otolithic membrane

1990 • 85 citations

Narrow linear strips of adhesive substratum are powerful inducers of both growth and total focal contact area

1990 • 79 citations

Endothelial cell motility, integrin receptor clustering, and microfilament organization are inhibited by agents that increase intracellular cAMP.

1990 • 78 citations

Talin: Role at sites of cell‐substratum adhesion

1990 • 74 citations

Modulation of endothelial cell phenotype by cyclic stretch: Inhibition of collagen production

1990 • 69 citations

Microgravity decreases C-fos induction and serum response element activity

1990 • 67 citations

Cells Transmit Spatial Information by Orienting Collagen Fibers

1990 • 66 citations

Effect of Static Stretching on Elastin Production by Porcine Aortic Smooth Muscle Cells

1990 • 63 citations

Stimulation of adenylate cyclase activity in cultured endothelial cells subjected to cyclic stretch.

1990 • 50 citations

Effects of flow on the synthesis and release of fibronectin by endothelial cells

1990 • 49 citations

Extracellular matrix regulates proliferation and phospholipid turnover in glomerular epithelial cells

1990 • 44 citations

Mechanically induced orientation of adult rat cardiac myocytes in vitro

1990 • 39 citations

Shear stress-induced detachment of human polymorphonuclear leukocytes from endothelial cell monolayers

1989 • 33 citations

Mechanical stress and cellular metabolism in living soft tissue composites

1990 • 32 citations

Organization of intestinal epithelial cells into multicellular structures requires laminin and functional actin microfilaments

1991 • 28 citations

Mechanical confinement inhibits collagen synthesis in gel-cultured fibroblasts.

1989 • 27 citations

Specific associations between tubulin and G proteins: participation of cytoskeletal elements in cellular signal transduction.

1990 • 22 citations

Functional morphology of the telson‐uropod stretch receptor in the sand crab Emerita analoga

1990 • 20 citations

Involvement of the membrane cytoskeletal proteins and the src gene product in growth cone adhesion and movement

1990 • 16 citations

Regulation of integrin mobility and cytoskeletal association in normal and RSV-transformed chick embryo fibroblasts

1990 • 16 citations

The role of physical forces on cytotoxic T cell-target cell conjugate stability.

1990 • 11 citations