Vinculin Promotes Cell Spreading by Mechanically Coupling Integrins to the Cytoskeleton

Mechanotransduction Across the Cell Surface and Through the Cytoskeleton

1993 • 2,947 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton

1993 • 1,124 citations

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone.

1988 • 851 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

Filament organization revealed in platinum replicas of freeze-dried cytoskeletons.

1980 • 662 citations

Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmilling.

1985 • 637 citations

Induction of human vascular endothelial stress fibres by fluid shear stress

1984 • 538 citations

Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension

1994 • 528 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

SDS microslab linear gradient polyacrylamide gel electrophoresis

1978 • 465 citations

Actin, alpha-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells.

1976 • 454 citations

An interaction between vinculin and talin

1984 • 442 citations

Cellular Tensegrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis

1994 • 428 citations

Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.

1989 • 416 citations

F-actin binding site masked by the intramolecular association of vinculin head and tail domains

1995 • 371 citations

Actin Filament Stress Fibers in Vascular Endothelial Cells in Vivo

1983 • 334 citations

The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins

1979 • 298 citations

Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix

1995 • 234 citations

Interaction of alpha-actinin and vinculin with actin: opposite effects on filament network formation.

1981 • 230 citations

Effects of mechanical tension on protrusive activity and microfilament and intermediate filament organization in an epidermal epithelium moving in culture.

1986 • 230 citations

Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA.

1992 • 228 citations

Adhesion of culture cells to their substratum

1974 • 220 citations

An intramolecular association between the head and tail domains of vinculin modulates talin binding.

1994 • 212 citations

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.

1995 • 203 citations

The Physics of Cell Motility

1987 • 190 citations

Specific interaction of vinculin with α-actinin

1987 • 185 citations

Acidic phospholipids inhibit the intramolecular association between the N- and C-terminal regions of vinculin, exposing actin-binding and protein kinase C phosphorylation sites

1996 • 150 citations

Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells

1992 • 149 citations

Tyrosine phosphorylation and cytoskeletal tension regulate the release of fibroblast adhesions.

1995 • 142 citations

Spreading of trypsinized cells: Cytoskeletal dynamics and energy requirements

1990 • 137 citations

Cell locomotion: New research tests old ldeas on membrane and cytoskeletal flow

1991 • 133 citations

Extension of filopodia by motor‐dependent actin assembly

1992 • 127 citations

Stereo immunofluorescence microscopy: I. Threedimensional arrangement of microfilaments, microtubules and tonofilaments

1978 • 122 citations

Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts.

1991 • 116 citations

Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformation

1996 • 113 citations

Focal adhesion formation by f9 embryonal carcinoma cells after vinculin gene disruption

1995 • 110 citations

Evidence for an actin-containing cytoplasmic precursor of the focal contact and the timing of incorporation of vinculin at the focal contact.

1987 • 102 citations

Vinculin-deficient PC12 cell lines extend unstable lamellipodia and filopodia and have a reduced rate of neurite outgrowth.

1994 • 90 citations

Viscoelasticity in Wild-Type and Vinculin-Deficient (5.51) Mouse F9 Embryonic Carcinoma Cells Examined by Atomic Force Microscopy and Rheology

1996 • 82 citations

Native Talin Is a Dumbbell-Shaped Homodimer When It Interacts with Actin

1994 • 76 citations

The cytoskeletal protein talin contains at least two distinct vinculin binding domains

1993 • 73 citations

Microfilament-based motility in non-muscle cells

1989 • 70 citations

Cytomechanics: The Mechanical Basis of Cell Form and Structure

1987 • 56 citations

Motility of Vinculin-Deficient F9 Embryonic Carcinoma Cells Analyzed by Video, Laser Confocal, and Reflection Interference Contrast Microscopy

1995 • 55 citations

Expression of chicken vinculin complements the adhesion-defective phenotype of a mutant mouse F9 embryonal carcinoma cell.

1993 • 46 citations

Vinculin, talin and focal adhesions

1996 • 42 citations

Augmentation of alpha-actinin-induced gelation of actin by talin.

1992 • 36 citations

Kinetic determination of talin-actin binding

1991 • 36 citations

[40] Measurement of actin polymerization and cross-linking in agonist-stimulated cells

1991 • 35 citations

An adhesion-defective variant of F9 embryonal carcinoma cells fails to differentiate into visceral endoderm

1987 • 27 citations

Overexpression of uvomorulin in a compaction-negative F9 mutant cell line

1991 • 9 citations