Genetic and Infectious Prion Diseases

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive, and X-Linked Phenotypes.

1967 • 1,002 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

1991 • 871 citations

Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

1989 • 834 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Experimental Transmission of a Kuru-like Syndrome to Chimpanzees

1966 • 828 citations

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

1991 • 812 citations

Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee

1968 • 778 citations

CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER: A SPONGIFORM ENCEPHALOPATHY

1980 • 760 citations

Bovine spongiform encephalopathy: epidemiological studies.

1988 • 721 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: Disease Phenotype Determined by a DNA Polymorphism

1992 • 680 citations

Does the Agent of Scrapie Replicate without Nucleic Acid ?

1967 • 671 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Creutzfeldt‐Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clustering

1979 • 618 citations

Fatal Familial Insomnia, a Prion Disease with a Mutation at Codon 178 of the Prion Protein Gene

1992 • 588 citations

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing

1993 • 578 citations

Degenerative Disease of the Central Nervous System in New Guinea

1957 • 570 citations

Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease

1991 • 543 citations

CREUTZFELDT-JAKOB DISEASE VIRUS ISOLATIONS FROM THE GERSTMANN-STRÄUSSLER SYNDROME

1981 • 534 citations

Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein

1990 • 531 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Purification and structural studies of a major scrapie prion protein

1984 • 497 citations

Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 • 497 citations

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1985 • 490 citations

Distinct prion proteins in short and long scrapie incubation period mice

1987 • 482 citations

Further purification and characterization of scrapie prions

1982 • 464 citations

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

1992 • 440 citations

Identification of a gene which controls the incubation period of some strains of scrapie agent in mice

1968 • 425 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

SCRAPIE AND KURU

1959 • 403 citations

The exceptionally small size of the scrapie agent

1966 • 403 citations

Creutzfeldt‐Jakob disease: Clinical analysis of a consecutive series of 230 neuropathologically verified cases

1986 • 400 citations

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

1988 • 366 citations

Homozygotes for Huntington's disease

1987 • 356 citations

"Friendly fire" in medicine: hormones, homografts, and Creutzfeldt-Jakob disease

1992 • 354 citations

Scrapie in mice

1973 • 340 citations

Molecular Cloning of a Human Prion Protein cDNA

1986 • 337 citations

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes

1993 • 331 citations

Purification and properties of the cellular and scrapie hamster prion proteins

1988 • 330 citations

Regional mapping of prion proteins in brain.

1992 • 329 citations

Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.

1991 • 328 citations

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.

1992 • 327 citations

The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).

1986 • 322 citations

Biological Evidence that Scrapie Agent Has an Independent Genome

1987 • 320 citations

SUBACUTE SPONGIFORM ENCEPHALOPATHY (CREUTZFELDT-JAKOB DISEASE)

1978 • 311 citations

The epidemiology of Creutzfeldt‐Jakob disease

1987 • 307 citations

A 'unified theory' of prion propagation

1991 • 304 citations

SPONGIFORM ENCEPHALOPATHY OF ROCKY MOUNTAIN ELK

1982 • 303 citations

Two alleles of a neural protein gene linked to scrapie in sheep.

1990 • 301 citations

Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein

1989 • 300 citations

Über eigenartige erkrankungen des zentralnervensystems mit bemerkenswertem anatomischen befunde

1921 • 300 citations

Identification of prion amyloid filaments in scrapie-infected brain

1985 • 293 citations

Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library.

1988 • 286 citations

Pathology of Kuru.

1959 • 284 citations

Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.

1990 • 279 citations

Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid

1992 • 278 citations

Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie

1989 • 277 citations

Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters

1992 • 276 citations

Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease

1991 • 273 citations

Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome

1989 • 268 citations

Changes in the localization of brain prion proteins during scrapie infection

1987 • 268 citations

Antibodies to a scrapie prion protein

1984 • 260 citations

Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis

1991 • 259 citations

Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome

1989 • 254 citations

Creutzfeldt-Jakob disease probably acquired from a cadaveric dura mater graft

1988 • 253 citations

Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles

1992 • 240 citations

Temporary and Permanent Modifications to a Single Strain of Mouse Scrapie on Transmission to Rats and Hamsters

1987 • 240 citations

THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

1981 • 233 citations

Scrapie PrP 27-30 is a sialoglycoprotein

1985 • 231 citations

Prion dementia without characteristic pathology

1990 • 230 citations

Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins

1990 • 217 citations

Turn prediction in proteins using a pattern-matching approach

1986 • 212 citations

Scrapie agent contains a hydrophobic protein.

1981 • 211 citations

Über eine eigenartige hereditär- familiäre Erkrankung des Zentralnervensystems

1954 • 207 citations

Immunoaffinity purification and neutralization of scrapie prion infectivity.

1988 • 205 citations

Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene

1992 • 204 citations

THE CLINICAL CHARACTERISTICS OF TRANSMISSIBLE CREUTZFELDT-JAKOB DISEASE

1973 • 200 citations

Fatal familial insomnia

1992 • 200 citations

Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells.

1991 • 198 citations

Creutzfeldt–Jakob Disease Prion Proteins in Human Brains

1985 • 197 citations

Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.

1991 • 195 citations

Evidence for case-to-case transmission of Creutzfeldt-Jakob disease

1982 • 195 citations

Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents

1979 • 193 citations

An Amber Mutation of Prion Protein in Gerstmann-Sträussler Syndrome with Mutant PrP Plaques

1993 • 191 citations

Kuru

1959 • 187 citations

Purified prion proteins and scrapie infectivity copartition into liposomes.

1987 • 186 citations

Scrapie: A transmissible and hereditary disease of sheep

1962 • 185 citations

Clinical and Pathological Features and Laboratory Confirmation of Creutzfeldt–Jakob Disease in a Recipient of Pituitary-Derived Human Growth Hormone

1985 • 178 citations

Amyloid plaques in Creutzfeldt‐Jakob disease stain with prion protein antibodies

1986 • 175 citations

Gerstmann‐Sträussler‐Scheinker disease II. Neurofibrillary tangles and plaques with PrP‐amyloid coexist in an affected family

1989 • 173 citations

Creutzfeldt–Jakob Disease in a Young Adult with Idiopathic Hypopituitarism

1985 • 171 citations

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.

1990 • 170 citations

INHERITED PRION DISEASE WITH 144 BASE PAIR GENE INSERTION: 2. CLINICAL AND PATHOLOGICAL FEATURES

1992 • 169 citations

INHERITED PRION DISEASE WITH 144 BASE PAIR GENE INSERTION: 1. GENEALOGICAL AND MOLECULAR STUDIES

1992 • 168 citations

Experimental Subacute Spongiform Virus Encephalopathies in Primates and Other Laboratory Animals

1973 • 167 citations

Creutzfeldt-Jakob disease in England and Wales, 1980-1984: a case-control study of potential risk factors.

1988 • 166 citations

The possible nature of the transmissible agent of scrapie

1967 • 164 citations

Genetic Aspects of Unconventional Virus Infections: The Basis of the Virino Hypothesis

2007 • 164 citations

Linkage of the Scrapie-associated Fibril Protein (PrP) Gene and Sinc Using Congenic Mice and Restriction Fragment Length Polymorphism Analysis

1987 • 159 citations

Inherited human prion diseases

1990 • 157 citations

Prion-Protein Immunoreactivity in Human Transmissible Dementias

1986 • 157 citations

Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations

1988 • 155 citations

Diagnosis of Creutzfeldt-Jakob Disease by Western Blot Identification of Marker Protein in Human Brain Tissue

1986 • 154 citations

Genomic structure of the human prion protein gene.

1991 • 152 citations

Creutzfeldt-Jakob Disease: Focus among Libyan Jews in Israel

1974 • 152 citations

Subacute spongiform virus encephalopathies. Scrapie, Kuru and Creutzfeldt-Jakob disease: a review.

1972 • 151 citations

A prion protein variant in a family with the telencephalic form of Gerstmann‐Sträussler‐Scheinker syndrome

1991 • 150 citations

Creutzfeldt-Jakob Disease in Pituitary Growth Hormone Recipients in the United States

1991 • 148 citations

DIAGNOSIS OF GERSTMANN-STRÄUSSLER SYNDROME IN FAMILIAL DEMENTIA WITH PRION PROTEIN GENE ANALYSIS

1989 • 148 citations

An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease

1990 • 148 citations

CREUTZFELDT-JAKOB DISEASE AFTER ADMINISTRATION OF HUMAN GROWTH HORMONE

1985 • 148 citations

Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy

1991 • 146 citations

Viroids and prions.

1982 • 145 citations

Bovine spongiform encephalopathy: epidemiological features 1985 to 1990

1992 • 144 citations

Oral Transmission of Kuru, Creutzfeldt-Jakob Disease, and Scrapie to Nonhuman Primates

1980 • 144 citations

Precautions in Medical Care of, and in Handling Materials from, Patients with Transmissible Virus Dementia (Creutzfeldt-Jakob Disease)

1977 • 142 citations

Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene

1991 • 142 citations

Advances in veterinary research.

1946 • 138 citations

Linkage of the gene for the scrapie-associated fibril protein (PrP) to the Sip gene in Cheviot sheep

1989 • 137 citations

Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da

1988 • 136 citations

Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis

1992 • 131 citations

Creutzfeldt-Jacob disease associated with the PRNP codon 200LYS mutation: An analysis of 45 families

1991 • 130 citations

The prion's progress

1991 • 128 citations

The new biology of spongiform encephalopathy: infectious amyloidoses with a genetic twist

1991 • 124 citations

Sulfated glycosaminoglycans in amyloid plaques of prion diseases

1989 • 123 citations

Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent

1981 • 123 citations

Virologic and Neurohistologic Findings in Dairy Goats Affected with Natural Scrapie

1980 • 122 citations

Epidemiology of Creutzfeldt-Jakob disease

1993 • 120 citations

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]

1987 • 119 citations

A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity.

1991 • 118 citations

Purified scrapie prions resist inactivation by UV irradiation

1987 • 118 citations

A case control study of Creutzfeldt‐Jakob disease: Association with physical injuries

1982 • 118 citations

DEGENERATION OF THE CEREBELLAR AND HYPOTHALAMO NEUROHYPOPHYSIAL SYSTEMS IN SHEEP WITH SCRAPIE; AND ITS RELATIONSHIP TO HUMAN SYSTEM DEGENERATIONS

1964 • 117 citations

Creutzfeldt‐Jakob disease in a recipient of human pituitary‐derived gonadotrophin

1990 • 115 citations

AMYLOID PLAQUES IN THE BRAINS OF MICE INFECTED WITH SCRAPIE: MORPHOLOGICAL VARIATION AND STAINING PROPERTIES

1975 • 113 citations

Precautions in handling tissues, fluids, and other contaminated materials from patients with documented or suspected Creutzfeldt-Jakob disease

1986 • 113 citations

Mortality, neoplasia, and Creutzfeldt-Jakob disease in patients treated with human pituitary growth hormone in the United Kingdom.

1991 • 113 citations

Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids

1991 • 111 citations

Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer.

1990 • 108 citations

Creutzfeldt‐Jakob disease cosegregates with the codon 178^AsnPRNP mutation in families of European origin

1992 • 107 citations

JAKOB-CREUTZFELDT DISEASE

1968 • 105 citations

The Natural Incubation Period of Kuru and the Episodes of Transmission in Three Clusters of Patients

1984 • 102 citations

Partial purification and evidence for multiple molecular forms of the scrapie agent

1978 • 101 citations

An analysis of natural scrapie in suffolk sheep

1965 • 98 citations

Bovine Spongiform Encephalopathy

1991 • 95 citations

Bovine spongiform encephalopathy: aspects of the clinical picture and analyses of possible changes 1986-1990

1992 • 95 citations

Familial dementia with PrP‐positive amyloid plaques

1989 • 94 citations

A dementing illness associated with a novel insertion in the prion protein gene

1992 • 93 citations

Immunochemical, molecular genetic, and transmission studies on a case of Gerstmann‐Straussler‐Scheinker syndrome

1990 • 93 citations

Phenotypic characteristics of familial Creutzfeldt‐Jakob disease assoicated with the codon 178^AsnPRNP mutation

1992 • 92 citations

Purified scrapie prions resist inactivation by procedures that hydrolyze, modify, or shear nucleic acids

1987 • 89 citations

Experimental transmission of BSE and scrapie to the common marmoset

1993 • 88 citations

Physical properties of the Creutzfeldt-Jakob disease agent

1989 • 87 citations

The Relative Susceptibility of Sheep, Goats and Mice to Two Types of the Goat Scrapie Agent

1966 • 86 citations

Gerstmann‐Sträussler‐Scheinker disease. I. Extending the clinical spectrum

1989 • 84 citations

Scrapie: concept of a virus-induced amyloidosis of the brain.

1985 • 82 citations

Immunoblotting of Creutzfeldt‐Jakob disease prion proteins: Host species—specific epitopes

1987 • 81 citations

CREUTZFELDT-JAKOB DISEASE: A CASE-CONTROL STUDY

1973 • 81 citations

CNS amyloid proteins in neurodegenerative diseases

1988 • 81 citations

Transmission of Scrapie in Hamsters

1985 • 78 citations

Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants.

1985 • 77 citations

Kuru-plaques in a case of Creutzfeldt-Jakob disease

1971 • 77 citations

Creutzfeldt‐Jakob disease in a patient with a cadaveric dural graft

1991 • 77 citations

Familial Neurological Disease Associated With Spongiform Encephalopathy

1976 • 74 citations

Properties of scrapie prion protein liposomes.

1988 • 69 citations

The Ataxic Form of Creutzfeldt-Jakob Disease

1973 • 69 citations

Experimental transmission of an autosomal dominant spongiform encephalopathy: does the infectious agent originate in the human genome?

1985 • 69 citations

Cloning of a Gene Whose Expression Is Increased in Scrapie and in Senile Plaques in Human Brain

1985 • 68 citations

Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene and their association with susceptibility to natural scrapie in British sheep

1991 • 68 citations

Neurofibrillary tangles of the Indiana kindred of Gerstmann-Stra¨ussler-Scheinker disease share antigenic determinants with those of Alzheimer disease

1990 • 67 citations

Prion protein mutation at codon 102 in an Italian family with Gerstmann‐Sträussler‐Scheinker syndrome

1992 • 67 citations

RESISTANCE OF THE SCRAPIE AGENT TO INACTIVATION BY PSORALENS

1983 • 67 citations

Interspecies transmission of Creutzfeldt-Jakob disease to Syrian hamsters with reference to clinical syndromes and strains of agent.

1978 • 66 citations

Search for a Scrapie‐Specific Nucleic Acid: A Progress Report

2007 • 66 citations

Geographical distribution of cases of Creutzfeldt-Jakob disease in England and Wales 1970-84.

1990 • 65 citations

Analysis of linkage between scrapie incubation period and the prion protein gene in mice

1990 • 64 citations

Kuru with incubation periods exceeding two decades

1982 • 64 citations

THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY

1982 • 63 citations

AN EPIDEMIOLOGIC CRITIQUE OF CREUTZFELDT-JAKOB DISEASE

1980 • 62 citations

Creutzfeldt-Jakob Disease: Hypothesis for High Incidence in Libyan Jews in Israel

1974 • 61 citations

Serial propagation of Creutzfeldt-Jakob disease in guinea pigs.

1976 • 60 citations

Alzheimer's Disease

1966 • 60 citations

LARGE-SCALE PREPARATION OF HIGHLY PURIFIED PYROGEN-FREE HUMAN GROWTH HORMONE FOR CLINICAL USE

1979 • 59 citations

Deletion in prion protein gene in a Moroccan family

1990 • 58 citations

Experimental transmission of human subacute spongiform encephalopathy to small rodents

1981 • 57 citations

Feline spongiform encephalopathy: fibril and PrP studies

1992 • 57 citations

Potential retroviral RNAs in Creutzfeldt-Jakob disease

1990 • 57 citations

Progressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure

1990 • 56 citations

Gerstmann‐Sträussler‐Scheinker disease: Immunohistological and experimental studies

1988 • 55 citations

The molecular pathogenesis of astrogliosis in scrapie and Alzheimer's disease

1987 • 55 citations

PRIONS CAUSING DEGENERATIVE NEUROLOGICAL DISEASES

1987 • 55 citations

Human alpha 2(VI) collagen gene. Heterogeneity at the 5'-untranslated region generated by an alternate exon.

1992 • 55 citations

Presence of mitochondrial D-loop DNA in scrapie-infected brain preparations enriched for the prion protein

1990 • 54 citations

Creutzfeldt‐Jakob disease

1979 • 52 citations

Transmissible spongiform encephalopathies: The threat of BSE to man

1990 • 51 citations

Fifty years with scrapie: a personal reminiscence.

1988 • 50 citations

Transmissible mink encephalopathy. Reduced spongiform degeneration in aged mink of the Chediak-Higashi genotype.

1976 • 49 citations

Cerebellar plaques in familial Alzheimer's disease (Gerstmann-Str�ussler-Scheinker variant?)

1985 • 49 citations

Creutzfeldt-Jakob disease and kuru patients lack a mutation consistently found in the Gerstmann-Sträussler-Scheinker syndrome

1990 • 48 citations

Evidence of mitochondrial involvement in scrapie infection

1989 • 48 citations

Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition

1991 • 47 citations

Gerstmann-Straussler-Scheinker disease in an Alsatian family: clinical and genetic studies.

1992 • 47 citations

Replication of the scrapie agent in ocular neural tissues.

1980 • 47 citations

Neuropathologic verification of Creutzfeldt‐Jakob disease in the exhumed American recipient of human pituitary growth hormone

1986 • 46 citations

Insertions in the prion protein gene in atypical dementias

1991 • 46 citations

Do Creutzfeldt-Jakob disease patients of Jewish Libyan origin have unique clinical features?

1991 • 45 citations

Combination Ultrafiltration and 6 MUrea Treatment of Human Growth Hormone Effectively Minimizes Risk from Potential Creutzfeldt-Jakob Disease Virus Contamination

1991 • 44 citations

KURU—A SUBACUTE CEREBELLAR DEGENERATION

1968 • 44 citations

PREPARATION OF GROWTH HORMONE FREE FROM CONTAMINATION WITH UNCONVENTIONAL SLOW VIRUSES

1985 • 44 citations

Gel electrophoresis and glass permeation chromatography of the hamster scrapie agent after enzymatic digestion and detergent extraction

1980 • 43 citations

The search for scrapie agent nucleic acid

1990 • 43 citations

TRANSMISSION AND SCANNING ELECTRON MICROSCOPY OF SPONGIFORM CHANGE IN CREUTZFELDT-JAKOB DISEASE

1980 • 42 citations

Nuclease-resistant polyadenylated RNAs of significant size are detected by PCR in highly purified Creutzfeldt-Jakob disease preparations

1990 • 42 citations

Amyloid plaques in the brains of mice with Creutzfeldt–Jakob disease

1984 • 40 citations

The Pathology of Scrapie: A Comparative Study of Lesions in the Brain of Sheep and Goats

1962 • 37 citations

Properties of the transmissible agent derived from chronic spongiform encephalopathy

1980 • 36 citations

Nuclease treatment results in high specific purification of Creutzfeldt-Jakob disease infectivity with a density characteristic of nucleic acid-protein complexes

1990 • 35 citations

The Libyan Creutzfeldt‐Jakob disease focus in Israel

1991 • 33 citations

Gerstmann‐Sträussler‐Scheinker's disease

1983 • 32 citations

Transmissible spongiform encephalopathy in greater kudu (Tragelaphus strepsiceros)

1993 • 31 citations

Preclinical Creutzfeldt‐Jakob disease discovered at autopsy in a human growth hormone recipient

1988 • 30 citations

OBSERVATIONS ON KURU: II. CLINICAL FEATURES

1959 • 30 citations

A new case of Creutzfeldt‐Jakob disease associated with human growth hormone therapy in New Zealand

1988 • 30 citations

The Last Arab Jews: The Communities of Jerba, Tunisia

1989 • 30 citations

Gerstmann‐Sträussler‐Scheinker disease with coincidental familial onset

1983 • 28 citations

Experimental transmission of human subacute spongiform encephalopathy to small rodents

1984 • 28 citations

Creutzfeldt‐Jakob disease following pituitary‐derived human growth hormone therapy

1988 • 28 citations

Familial Creutzfeldt-Jakob disease in Finland: Epidemiological, clinical, pathological and molecular genetic studies

1991 • 26 citations

ÜBER EINE DER MULTIPLEN SKLEROSE KLINISCH NAHESTEHENDE ERKRANKUNG DES CENTRALNER VENSYSTEMS (SPASTISCHE PSEUDOSKLEROSE) MIT BEMERKENSWERTEM ANATOMISCHEM BEFUNDE

1989 • 26 citations

Allele‐specific sequencing confirms novel prion gene polymorphism in Creutzfeldt‐Jakob disease

1991 • 25 citations

A variant of Gerstmann-Sträussler-Scheinker disease with ß -protein epitopes and dystrophic neurites in the peripheral regions of PrP -immunoreactive amyloid plaques

1991 • 24 citations

Protease sensitivity and nuclease resistance of the scrapie agent propagated in vitro in neuroblastoma cells

1991 • 23 citations

The Implications of Sociobiology

1976 • 21 citations

Molecular Biology and Genetics of Neurodegenerative Diseases Caused By Prions

1992 • 20 citations

Immunohistochemical verification of senile and kuru plaques in Creutzfeldt‐Jakob disease and the allied disease

1988 • 18 citations

Prion dimers: a deadly duo

1991 • 18 citations

Kuru plaques in the brain of two cases with Creutzfeldt-Jakob disease

1979 • 17 citations

CREUTZFELDT-JAKOB DISEASE WITH KURU-LIKE PLAQUES IN JAPAN

1981 • 16 citations

Gerstmann-Str�ussler's disease, atypical multiple sclerosis and carcinomas in a family of sheepbreeders

1982 • 12 citations

Creutzfeldt-Jakob disease and dementias

1989 • 11 citations

Creutzfeldt-Jakob disease and sheep brain a report from central and southern Italy

1979 • 10 citations

Uber eigenartige Erkrankungen des Zentralnervensystems mit bemerkenswerten anatomischen befunde (Spastische Pseudosklerose-Encehpalomyelopathie mit disseminierten Degenerationsherden)

1921 • 5 citations

Spino-Cerebello-Cerebral Degeneration with Amyloid Plaques (Gerstmann, Sträussler, Scheinker Syndrome)

1982 • 4 citations