Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons

1980 • 995 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Experimental Transmission of a Kuru-like Syndrome to Chimpanzees

1966 • 828 citations

Creutzfeldt-Jakob Disease (Spongiform Encephalopathy): Transmission to the Chimpanzee

1968 • 778 citations

CHRONIC WASTING DISEASE OF CAPTIVE MULE DEER: A SPONGIFORM ENCEPHALOPATHY

1980 • 760 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam

1982 • 678 citations

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION

1965 • 615 citations

Degenerative Disease of the Central Nervous System in New Guinea

1957 • 570 citations

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

1986 • 553 citations

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

1982 • 541 citations

CREUTZFELDT-JAKOB DISEASE VIRUS ISOLATIONS FROM THE GERSTMANN-STRÄUSSLER SYNDROME

1981 • 534 citations

Slow transmissible diseases of the nervous system

1979 • 503 citations

Purification and structural studies of a major scrapie prion protein

1984 • 497 citations

Abnormal fibrils from scrapie-infected brain

1981 • 473 citations

ALUMINOSILICATES AND SENILE PLAQUE FORMATION IN ALZHEIMER'S DISEASE

1986 • 449 citations

Isolation of Low‐Molecular‐Weight Proteins from Amyloid Plaque Fibers in Alzheimer's Disease

1986 • 443 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral Sclerosis

1984 • 355 citations

Scrapie infectivity, fibrils and low molecular weight protein

1983 • 345 citations

EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION

1965 • 332 citations

SPONGIFORM ENCEPHALOPATHY OF ROCKY MOUNTAIN ELK

1982 • 303 citations

Fine Structural Study of Neurofibrillary Changes in a Family with Amyotrophic Lateral Sclerosis

1984 • 300 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

Pathology of Kuru.

1959 • 284 citations

Antibodies to a scrapie prion protein

1984 • 260 citations

Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam.

1984 • 244 citations

THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

1981 • 233 citations

Potential Epidemic of Creutzfeldt–Jakob Disease from Human Growth Hormone Therapy

1985 • 233 citations

Scrapie PrP 27-30 is a sialoglycoprotein

1985 • 231 citations

Heterogeneous and Epitaxial Nucleation of Protein Crystals on Mineral Surfaces

1988 • 230 citations

Hypothesis: Interference with Axonal Transport of Neurofilament as a Common Pathogenetic Mechanism in Certain Diseases of the Central Nervous System

1985 • 217 citations

Infection-Specific Particle from the Unconventional Slow Virus Diseases

1984 • 214 citations

Some Speculations about Prions, Amyloid, and Alzheimer's Disease

1984 • 212 citations

Biological Aspects of Alzheimer's Disease

1984 • 203 citations

Scrapie-associated fibrils in Creutzfeldt–Jakob disease

1983 • 199 citations

Creutzfeldt–Jakob Disease Prion Proteins in Human Brains

1985 • 197 citations

Amyloid β Protein Precursor Is Possibly a Heparan Sulfate Proteoglycan Core Protein

1988 • 189 citations

Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe.

1985 • 188 citations

β Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome

1987 • 187 citations

Kuru

1959 • 187 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Scrapie in Mice: Ultrastructural Observations in the Cerebral Cortex

1968 • 185 citations

Amyotrophic lateral sclerosis and parkinsonian syndromes in high incidence among the Auyu and Jakai people of West New Guinea

1982 • 185 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Amyloid plaques in Creutzfeldt‐Jakob disease stain with prion protein antibodies

1986 • 175 citations

Scrapie infectious agent is virus-like in size and susceptibility to inactivation

1984 • 161 citations

Newer Data on the Inactivation of Scrapie Virus or Creutzfeldt-Jakob Disease Virus in Brain Tissue

1986 • 159 citations

Diagnosis of Creutzfeldt-Jakob Disease by Western Blot Identification of Marker Protein in Human Brain Tissue

1986 • 154 citations

In vitro formation of amyloid fibrils from intact β2-microglobulin

1985 • 153 citations

Molecular characteristics of the major scrapie prion protein

1984 • 152 citations

Aluminum effect on slow axonal transport: a novel impairment of neurofilament transport

1984 • 151 citations

Chemical Disinfection of Creutzfeldt–Jakob Disease Virus

1982 • 144 citations

SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS

1967 • 141 citations

Inactivation of the Scrapie Agent by Near Monochromatic Ultraviolet Light

1970 • 139 citations

Autoantibodies Against Axonal Neurofilaments in Patients with Kuru and Creutzfeldt-Jakob Disease

1980 • 139 citations

Replication and Evolution in Inorganic Systems

1981 • 131 citations

Isolation and Partial Characterization of Neurofibrillary Tangles and Amyloid Plaque Core in Alzheimerʼs Disease

1986 • 128 citations

Circulating Autoantibodies to the 200,000-Dalton Protein of Neurofilaments in the Serum of Healthy Individuals

1985 • 121 citations

Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system

1980 • 110 citations

Specific proteins associated with Creutzfeldt-Jakob disease and scrapie share antigenic and carbohydrate determinants.

1985 • 108 citations

Subviral Pathogens of Plants and Animals: Viroids and Prions

1985 • 108 citations

CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID-BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE

1988 • 104 citations

Effect of Chemicals, Heat, and Histopathologic Processing on High-Infectivity Hamster-Adapted Scrapie Virus

1982 • 104 citations

EXPERIMENTAL SPONGIFORM ENCEPHALOPATHY (CREUTZFELDT-JAKOB DISEASE) IN CHIMPANZEES

1971 • 104 citations

Neurofibrillary Changes in Human Brain

1983 • 103 citations

NEUROFIBRILLARY DEGENERATION ON GUAM

1979 • 103 citations

Aluminum intoxication: a disorder of neurofilament transport in motor neurons

1985 • 103 citations

Enhancement of amyloid induction by amyloid fibril fragments in hamster.

1987 • 99 citations

Amyloid of neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence.

1987 • 98 citations

Virus-Like Sensitivity of the Scrapie Agent to Heat Inactivation

1984 • 94 citations

The complete amino acid sequence of the major mammalian neurofilament protein (NF‐L)

1985 • 93 citations

Electron microscopic observations on the cerebellar cortex in Kuru

1969 • 91 citations

Scrapie in Immunologically Deficient Mice

1971 • 88 citations

Scrapie: concept of a virus-induced amyloidosis of the brain.

1985 • 82 citations

Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants.

1985 • 77 citations

Sharing of Specific Antigens by Degenerating Neurons in Pick's Disease and Alzheimer's Disease

1985 • 73 citations

Serum antibodies to neurofilament antigens in patients with neurological and other diseases and in healthy controls

1983 • 71 citations

The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein.

1985 • 70 citations

Biochemistry of Silicon and Related Problems

1979 • 69 citations

Method for preparing cultures of central neurons: cytochemical and immunochemical studies.

1980 • 68 citations

VIRUS-LIKE PARTICLES AND NUCLEOPROTEIN-TYPE FILAMENTS IN BRAIN TISSUE FROM TWO PATIENTS WITH CREUTZFELDT-JAKOB DISEASE

1970 • 68 citations

THE PATHOGENESIS OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHY

1982 • 63 citations

EXPERIMENTAL KURU IN THE SPIDER MONKEY

1975 • 62 citations

Studies in Ageing of the Brain

1972 • 61 citations

Neurofibrillary Change on Guam

1981 • 58 citations

Antibodies to neurofibrillary tangles of Alzheimer's disease raised from human and animal neurofilament fractions.

1983 • 57 citations

An electron-microscopic study of scrapie in the rat: Further observations on “inclusion bodies” and virus-like particles

1972 • 57 citations

The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from patients with kuru, Creutzfeldt-Jakob disease, and other neurologic diseases.

1985 • 56 citations

Computer Recreations

1984 • 52 citations

Further Studies on the Inactivation of the Scrapie Agent by Ultraviolet Light

1969 • 45 citations

An electron microscopic study of natural scrapie sheep brain: Further observations on virus-like particles and paramyxovirus-like tubules

1974 • 44 citations

Evidence that DNA is present in abnormal tubulofilamentous structures found in scrapie.

1988 • 41 citations

Scrapie-Associated Particles in Postsynaptic Processes Further Ultrastructural Studies

1981 • 37 citations

Amyotrophic lateral sclerosis: concepts in pathogenesis and etiology.

1987 • 36 citations

Heterogeneic Autoantibody Against Neurofilament Protein in the Sera of Animals with Experimental Kuru and Creutzfeldt-Jakob Disease and Natural Scrapie Infection

1982 • 31 citations

Tubulofilaments in negatively stained scrapie-infected brains: relationship to scrapie-associated fibrils.

1987 • 31 citations

Studies in Ageing of the Brain.

1973 • 30 citations

Characterization of Antineurofilament Autoantibodies in Creutzfeldt-Jakob Disease

1984 • 29 citations

Scrapie Agent and Neurones

1972 • 29 citations

An electron microscopic study of the scrapie mouse and rat: further observations on virus-like particles with ruthenium red and lanthanum nitrate as a possible trace and negative stain.

1974 • 29 citations

Search for Scrapie-specific RNA and Attempts to Detect an Infectious DNA or RNA

1976 • 27 citations

Toward Development of Assays for Scrapie-Specific Antibodies

1981 • 26 citations

Silicon Levels in Human Tissues

1978 • 25 citations

The 200- and 150-kDa neurofilament proteins react with IgG autoantibodies from chimpanzees with kuru or Creutzfeldt-Jakob disease; a 62-kDa neurofilament-associated protein reacts with sera from sheep with natural scrapie.

1985 • 25 citations

Characteristic Two-dimensional Patterns of Enzymatic Digests of Oncorna and Other Viral RNAs

1972 • 24 citations

Virus-like particles in natural scrapie of the sheep.

1973 • 22 citations

Computer Recreations

1985 • 21 citations

SUBACUTE SPONGIFORM VIRUS ENCEPHALOPATHIES CAUSED BY UNCONVENTIONAL VIRUSES

1985 • 21 citations

Focusing on the nature of the scrapie agent

1985 • 20 citations

Ultrastructural Studies of Spleens, Brains, and Brain Cell Cultures of Mice with Scrapie

1974 • 19 citations

Computer Recreations

1985 • 19 citations

Virus-like Particles in Natural Scrapie of the Sheep

1973 • 18 citations

The Clinical neurosciences

1975 • 17 citations

FURTHER OBSERVATIONS ON PARTICULATE STRUCTURES IN SCRAPIE AFFECTED BRAIN

1980 • 16 citations

Subacute spongiform encephalopathy: Electron microscopic studies

1972 • 16 citations

Inability to Transmit Scrapie by Transfection of Mouse Embryo Cells in vitro

1982 • 14 citations

Is silica involved in neuritic (senile) plaque formation?

1983 • 12 citations

Molecular hybridization studies with scrapie brain nucleic acids

1986 • 10 citations

Molecular hybridization studies with scrapie brain nucleic acids

1986 • 8 citations

Creutzfeldt–Jakob Disease Prion Proteins in Human Brains

1985 • 8 citations

Etiology Versus Pathogenesis: The Causes of Post-Translational Modifications of Host-Specified Brain Proteins to Amyloid Configuration

1988 • 8 citations

62 AMYLOID PLAQUE FORMATION ALONG THE NEEDLE TRACKS IN EXPERIMENTAL MURINE SCRAPIE

1984 • 7 citations

Bibliography of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam

1983 • 6 citations

Computer Recreations

1984 • 5 citations

Alternative cDNA Clones of Amyloid β Protein Precursor Gene Encode Proteinase Inhibitor

1988 • 3 citations