Distinct prion proteins in short and long scrapie incubation period mice

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Genomic sequencing.

1984 • 8,343 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Signal sequences

1985 • 2,179 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Rapid transfer of DNA from agarose gels to nylon membranes

1985 • 1,810 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

A colony bank containing synthetic CoI EI hybrid plasmids representative of the entire E. coli genome

1976 • 1,313 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

Unconventional Viruses and the Origin and Disappearance of Kuru

1977 • 897 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

Efficient transcription of RNA into DNA by avian sarcoma virus polymerase

1976 • 688 citations

Does the Agent of Scrapie Replicate without Nucleic Acid ?

1967 • 671 citations

ENCEPHALOPATHY IN MICE PRODUCED BY INOCULATION WITH SCRAPIE BRAIN MATERIAL

1961 • 505 citations

Purification and structural studies of a major scrapie prion protein

1984 • 497 citations

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1985 • 490 citations

Sequence diversity among related genes for recognition of specific targets in DNA molecules

1983 • 478 citations

Further purification and characterization of scrapie prions

1982 • 464 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state

1981 • 346 citations

Molecular Cloning of a Human Prion Protein cDNA

1986 • 337 citations

Escherichia coli K-12 restricts DNA containing 5-methylcytosine.

1986 • 325 citations

Biological Evidence that Scrapie Agent Has an Independent Genome

1987 • 320 citations

Identification of prion amyloid filaments in scrapie-infected brain

1985 • 293 citations

Isolation of β-globin-related genes from a human cosmid library

1981 • 277 citations

THE FAMILIAL OCCURRENCE OF CREUTZFELDT-JAKOB DISEASE AND ALZHEIMER'S DISEASE

1981 • 233 citations

Construction of coliphage lambda Charon vectors with BamHI cloning sites

1980 • 230 citations

Adenylic Acid-rich Sequence in RNAs of Rous Sarcoma Virus and Rauscher Mouse Leukaemia Virus

1972 • 229 citations

The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization procedures

1984 • 228 citations

Host-genotype and agent effects in scrapie incubation: Change in allelic interaction with different strains of agent

1971 • 220 citations

Purified prion proteins and scrapie infectivity copartition into liposomes.

1987 • 186 citations

Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.

1986 • 176 citations

Molecular characteristics of the major scrapie prion protein

1984 • 152 citations

Advances in veterinary research.

1946 • 138 citations

Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains

1986 • 137 citations

Phage Lambda and Molecular Cloning

1983 • 135 citations

Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]

1987 • 119 citations

Genetic control of scrapie and Creutzfeldt-Jakob disease in mice.

1983 • 104 citations

Predicted secondary structure and membrane topology of the scrapie prion protein

1987 • 88 citations

Immunoblotting of Creutzfeldt‐Jakob disease prion proteins: Host species—specific epitopes

1987 • 81 citations

Antibodies to the scrapie protein decorate prion rods.

1985 • 76 citations

Slow, latent and temperate virus infections

1968 • 70 citations

Genetic Control of Scrapie: Incubation Period and Plaque Formation in I Mice

1987 • 56 citations

SLOW, LATENT, AND TEMPERATE VIRUS INFECTIONS. NINDB MONOGRAPH No. 2

1967 • 55 citations

Genetical control of the incubation period in mice of the neurological disease, scrapie

1964 • 51 citations

PrP and the nature of the scrapie agent

1987 • 48 citations

Genetic studies in relation of kuru. I. Cultural, historical, and demographic background.

1972 • 35 citations

The molecular biology of scrapie: the last two years

1987 • 22 citations

Genetic Control of Prion Incubation Period in Mice

2007 • 11 citations

FURTHER CHANGES OF PATTERN in KURU

1966 • 7 citations