Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

1991 • 812 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

Structure of a protein superfiber: spider dragline silk.

1990 • 660 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Secondary structure and dosage of soluble and membrane proteins by attenuated total reflection Fourier‐transform infrared spectroscopy on hydrated films

1990 • 526 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Purification and structural studies of a major scrapie prion protein

1984 • 497 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

pH-dependent structural transitions of Alzheimer amyloid peptides

1991 • 376 citations

Structural comparison of two serine proteinase-protein inhibitor complexes: Eglin-C-subtilisin Carlsberg and CI-2-subtilisin Novo

1988 • 307 citations

β-PLEATED SHEET FIBRILS A COMPARISON OF NATIVE AMYLOID WITH SYNTHETIC PROTEIN FIBRILS

1974 • 294 citations

Identification of prion amyloid filaments in scrapie-infected brain

1985 • 293 citations

Structure and X-ray amino acid sequence of a bacteriochlorophyll a protein from Prosthecochloris aestuarii refined at 1.9 Å resolution

1986 • 292 citations

Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.

1990 • 279 citations

Synthesis and trafficking of prion proteins in cultured cells.

1992 • 268 citations

Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome

1989 • 268 citations

Antibodies to a scrapie prion protein

1984 • 260 citations

Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles

1992 • 240 citations

Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins

1990 • 217 citations

Turn prediction in proteins using a pattern-matching approach

1986 • 212 citations

Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells.

1991 • 198 citations

Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.

1991 • 195 citations

THE RELATION OF THE PROPERTIES OF CONGO RED-STAINED AMYLOID FIBRILS TO THE β-CONFORMATION

1972 • 191 citations

Purified prion proteins and scrapie infectivity copartition into liposomes.

1987 • 186 citations

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

1992 • 179 citations

Amyloid plaques in Creutzfeldt‐Jakob disease stain with prion protein antibodies

1986 • 175 citations

Identification of glycoinositol phospholipid-linked and truncated forms of the scrapie prion protein

1990 • 171 citations

Interdomain motion in liver alcohol dehydrogenase. Structural and energetic analysis of the hinge bending mode.

1986 • 156 citations

Use of polylysine for adsorption of nuclei acids and enzymes to electron microscope specimen films.

1977 • 153 citations

Alzheimer's disease: Its proteins and genes

1988 • 149 citations

Specifie codon usage pattern and its implications on the secondary structure of silk fibroin mRNA

1988 • 103 citations

Predicted secondary structure and membrane topology of the scrapie prion protein

1987 • 88 citations

Molecular Characteristics of Prion Rods Purified from Scrapie-Infected Hamster Brains

1986 • 67 citations

Human alpha 2(VI) collagen gene. Heterogeneity at the 5'-untranslated region generated by an alternate exon.

1992 • 55 citations

Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition

1991 • 47 citations

Amyloid-like properties of a synthetic peptide corresponding to the carboxy terminus of β-amyloid protein precursor

1992 • 29 citations