The Molecular Genetics of Rodent Single Gene Obesities

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

The Leptin Receptor

1997 • 1,300 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.

1979 • 1,145 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Transient increase in obese gene expression after food intake or insulin administration

1995 • 1,102 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans

1995 • 972 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Molecular characterization of the mouse agouti locus

1992 • 791 citations

Effects of gender, body composition, and menopause on plasma concentrations of leptin.

1996 • 769 citations

Leptin accelerates the onset of puberty in normal female mice.

1997 • 768 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro

1996 • 716 citations

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice.

1997 • 670 citations

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1995 • 669 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity.

1995 • 573 citations

Depot- and Sex-Specific Differences in Human Leptin mRNA Expression: Implications for the Control of Regional Fat Distribution

1997 • 554 citations

Increased obese mRNA expression in omental fat cells from massively obese humans

1995 • 527 citations

Expression of the Functional Leptin Receptor mRNA in Pancreatic Islets and Direct Inhibitory Action of Leptin on Insulin Secretion

1997 • 511 citations

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

1993 • 510 citations

Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice

1997 • 450 citations

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

1995 • 367 citations

Identification and Characterization of the Mouse Obesity Gene tubby: A Member of a Novel Gene Family

1996 • 366 citations

Adipose tissue leptin production and plasma leptin kinetics in humans

1996 • 356 citations

A candidate gene for the mouse mutation tubby

1996 • 346 citations

Obesity, diabetes, and neoplasia in yellow A ^vy /‐ mice: ectopic expression of the agouti gene

1994 • 306 citations

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur.

1995 • 290 citations

Leptin Receptor (OB-R) Signaling

1997 • 290 citations

Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse

1990 • 270 citations

Molecular Cloning of Rat Leptin Receptor Isoform Complementary DNAs—Identification of a Missense Mutation in Zucker Fatty (fa/fa) Rats

1996 • 264 citations

The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7.

1995 • 249 citations

Identification of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat Mutations

1996 • 225 citations

Brown Adipose Tissue Metabolism and Thermogenesis

1985 • 221 citations

Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat

1997 • 221 citations

A Short Form of Leptin Receptor Performs Signal Transduction

1997 • 211 citations

Structure and function of ASP, the human homolog of the mouse agouti gene

1995 • 184 citations

Identification of four chromosomal loci determining obesity in a multifactorial mouse model.

1995 • 182 citations

Molecular mapping of the mouse ob mutation

1991 • 179 citations

Indication for Linkage of the Human OB Gene Region With Extreme Obesity

1996 • 171 citations

Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects

1996 • 165 citations

Extreme Obesity May Be Linked to Markers Flanking the Human OB Gene

1996 • 157 citations

Onset of genetic obesity in the absence of hyperphagia during the first week of life in the Zucker rat (fa/fa).

1979 • 129 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7.

1996 • 121 citations

The agouti gene: turned on to yellow

1994 • 116 citations

Amino Acid Variants in the Human Leptin Receptor: Lack of Association to Juvenile Onset Obesity

1997 • 85 citations

Mechanisms for the pleiotropic effects of the agouti gene.

1995 • 75 citations

Mutation Screening and Identification of a Sequence Variation in the Human OB Gene Coding Region

1996 • 74 citations

Overexpression of anAgouticDNA in the Skin of Transgenic Mice Recapitulates Dominant Coat Color Phenotypes of Spontaneous Mutants

1996 • 73 citations

The Molecular Basis of the Obese Mutation in ob2JMice

1997 • 71 citations

Suggestive Linkages Between Markers on Human 1p32‐p22 and Body Fat and Insulin Levels in the Québec Family Study

1997 • 64 citations

Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.

1996 • 60 citations

Genetic Modifiers ofLeprfaAssociated with Variability in Insulin Production and Susceptibility to NIDDM

1997 • 57 citations

Evidence for Linkage Between a Region on Chromosome 1p and the Acute Insulin Response in Pima Indians

1995 • 49 citations

Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice ()

1974 • 47 citations

Acute, chronic, and interactive effects of type I and II corticosteroid receptor stimulation on feeding and weight gain

1990 • 31 citations

Absence of Linkage Between Human Obesity and the Mouse Agouti Homologous Region (20q11.2) or Other Markers Spanning Chromosome 20q

1995 • 13 citations

BLACKHEAD, A COCCIDIAL DISEASE OF TURKEYS

1908 • 13 citations

An experimental analysis of the recessive yellow coat color mutant in the mouse

1976 • 13 citations