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1993 • 6,011 citations

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1984 • 5,344 citations

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1993 • 4,225 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 • 2,355 citations

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

1995 • 1,613 citations

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

1998 • 1,451 citations

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

1991 • 1,399 citations

Translocation of Helicobacter pylori CagA into Gastric Epithelial Cells by Type IV Secretion

2000 • 1,261 citations

Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging

1998 • 1,182 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Helicobacter pylori Virulence and Genetic Geography

1999 • 1,064 citations

Helicobacter pylori infection induces gastric cancer in Mongolian gerbils

1998 • 997 citations

Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

1995 • 965 citations

Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer

1998 • 956 citations

Cure of duodenal ulcer associated with eradication of Helicobacter pylori

1990 • 943 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

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1993 • 732 citations

Purification and characterization of the vacuolating toxin from Helicobacter pylori.

1992 • 700 citations

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1988 • 681 citations

Helicobacter pyloriand Peptic Ulcer Disease

1991 • 673 citations

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori

1997 • 649 citations

Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori

1998 • 618 citations

Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin

1995 • 594 citations

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

1994 • 594 citations

Water source as risk factor for Helicobacter pylori infection in Peruvian children

1991 • 592 citations

Tyrosine phosphorylation of theHelicobacter pyloriCagA antigen aftercag-driven host cell translocation

2000 • 585 citations

Intrafamilial Clustering ofHelicobacter pyloriInfection

1990 • 582 citations

Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype

1998 • 574 citations

Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.

1995 • 534 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

A H ⁺ -Gated Urea Channel: The Link Between Helicobacter pylori Urease and Gastric Colonization

2000 • 490 citations

Relationship between Helicobacter pylori iceA , cagA , and vacA Status and Clinical Outcome: Studies in Four Different Countries

1999 • 488 citations

T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease.

1997 • 485 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection.

1994 • 433 citations

Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity

1996 • 427 citations

Induction of gastric epithelial apoptosis by Helicobacter pylori.

1996 • 425 citations

Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.

1995 • 412 citations

The incidence of Helicobacter pylori infection.

1995 • 393 citations

Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL‐8 in gastric epithelial cells

1995 • 393 citations

Stomach Cancer Among Japanese in Hawaii<xref ref-type="fn" rid="FN2">2</xref>

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Helicobacter pylori and gastric carcinoma: Serum antibody prevalence in populations with contrasting cancer risks

1990 • 382 citations

Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia.

1994 • 377 citations

Helicobacter pylori Infection in Intestinal- and Diffuse-Type Gastric Adenocarcinomas

1991 • 366 citations

Association ofCampylobacter pylorion the Gastric Mucosa with Antral Gastritis in Children

1987 • 365 citations

The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor

1998 • 363 citations

Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.

1995 • 360 citations

Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains

1997 • 355 citations

HELICOBACTER PYLORI-SPECIFIC TUMOUR-INFILTRATING T CELLS PROVIDE CONTACT DEPENDENT HELP FOR THE GROWTH OF MALIGNANT B CELLS IN LOW-GRADE GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE

1996 • 352 citations

Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.

1994 • 349 citations

Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: A model

1997 • 338 citations

Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa

1996 • 332 citations

Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa

1991 • 325 citations

Local Cytokine Response inHelicobacter pylori-Infected Subjects

1998 • 324 citations

Regulation of gastric epithelial cell growth by Helicobacter pylori: Offdence for a major role of apoptosis

1997 • 320 citations

Helicobacter pylori in the drinking water in Peru

1996 • 308 citations

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

1993 • 294 citations

Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro

1995 • 288 citations

Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection.

1997 • 276 citations

Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.

1995 • 258 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis.

1998 • 253 citations

Helicobacter pylori isolated from the domestic cat: public health implications

1994 • 244 citations

Changes in the gastric mucosa following eradication of Helicobacter pylori.

1993 • 242 citations

Patterns of gastro‐intestinal cancer in european migrants to Australia: The role of dietary change

1980 • 227 citations

Review article: the role of inflammation in the pathogenesis of gastric cancer

1999 • 219 citations

Patient-to-Patient Transmission of Campylobacter pylori Infection by Fiberoptic Gastroduodenoscopy and Biopsy

1990 • 218 citations

Different cytokine profile and antigen‐specificity repertoire in Helicobacter pylori‐specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer

1997 • 213 citations

Meningiomas and Gliomas in Juxtaposition

1995 • 212 citations

The Effect of Class II Major Histocompatibility Complex Expression on Adherence of Helicobacter pylori and Induction of Apoptosis in Gastric Epithelial Cells: A Mechanism for T Helper Cell Type 1–mediated Damage

1998 • 202 citations

Helicobacter pylori in hispanics: Comparison with blacks and whites of similar age and socioeconomic class

1992 • 202 citations

Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.

1994 • 196 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Helicobacter pyloriand gastric inflammation

1998 • 190 citations

Transmission and Epidemiology of Helicobacter pylori

1996 • 189 citations

Vector potential of houseflies (Musca domestica) for Helicobacter pylori

1997 • 185 citations

Transmission of Helicobacter pylori: faecal-oral versus oral-oral route.

1995 • 181 citations

Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens.

1999 • 178 citations

A Population-Based Serologic Survey of Helicobacter pylori Infection in Children and Adolescents in the United States

1996 • 177 citations

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1991 • 173 citations

Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.

1995 • 165 citations

Antrum- and Corpus Mucosa-Infiltrating CD4⁺Lymphocytes inHelicobacter pyloriGastritis Display a Th1 Phenotype

1998 • 157 citations

Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers

1999 • 156 citations

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1981 • 155 citations

Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations.

1993 • 155 citations

A study of the pathogenesis of Helicobacter pylori negative chronic duodenal ulceration.

1993 • 152 citations

Helicobacter pyloriInduces Gastric Epithelial Cell Apoptosis in Association with Increased Fas Receptor Expression

1999 • 151 citations

Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis

1998 • 143 citations

Cutting Edge: Chronic Intestinal Inflammation in STAT-4 Transgenic Mice: Characterization of Disease and Adoptive Transfer by TNF- Plus IFN-γ-Producing CD4+ T Cells That Respond to Bacterial Antigens

1999 • 143 citations

Helicobacter pylori Infection in Recurrent Abdominal Pain in Childhood: Comparison of Diagnostic Tests and Therapy

1995 • 137 citations

Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis.

1994 • 136 citations

Helicobacter pylori-negative duodenal ulcer.

1991 • 136 citations

Helicobacter pylori Lewis expression is related to the host Lewis phenotype

1997 • 135 citations

Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment.

1994 • 131 citations

Coccoid Forms ofHelicobacter pyloriin the Human Stomach

1994 • 130 citations

Bugs on trial: the case of Helicobacter pylori and autoimmunity

1998 • 128 citations

Fibroblasts modulate intestinal secretory responses to inflammatory mediators.

1992 • 120 citations

Long‐term follow‐up of gastric histology after Helicobacter pylori eradication

1996 • 113 citations

Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma

1999 • 110 citations

Helicobacter pyloriModulates Lymphoepithelial Cell Interactions Leading to Epithelial Cell Damage through Fas/Fas Ligand Interactions

2000 • 107 citations

Pathophysiology of Helicobacter pylori infection.

1994 • 107 citations

What is a pathogen

1997 • 103 citations

Increased expression of IL-10 and IL-12 (p40) mRNA in Helicobacter pylori infected gastric mucosa: relation to bacterial cag status and peptic ulceration.

1999 • 96 citations

Characterization of Helicobacter pylori PldA, a phospholipase with a role in colonization of the gastric mucosa

1999 • 93 citations

Carcinogenesis, apoptosis and cell proliferation

1998 • 92 citations

Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation.

1995 • 85 citations

Helicobacter pylori-negative duodenal ulcer

1991 • 82 citations

The Thioredoxin System of Helicobacter pylori

2000 • 80 citations

Helicobacter pyloriand Progressive Gastric Pathology that Predisposes to Gastric Cancer

1991 • 78 citations

Expression of the Neutrophil Chemokine KC in the Colon of Mice with Enterocolitis and by Intestinal Epithelial Cell Lines: Effects of Flora and Proinflammatory Cytokines

1999 • 76 citations

Pathophysiology ofHelicobacter pyloriInfection

1994 • 71 citations

Helicobacter pylori and associated duodenal ulcer.

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The epidemiology and transmission of Helicobacter pylori infection in children.

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Helicobacter pylori in Childhood: New Insights Into the Immunopathogenesis of Gastric Disease and Implications for Managing Infection in Children

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Differential Normalization of Mucosal Interleukin-8 and Interleukin-6 Activity afterHelicobacter pyloriEradication

1998 • 67 citations

Helicobacter pylori infection and gastric juice vitamin C levels

1995 • 65 citations

Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis.

1997 • 63 citations

Humoral and cellular immune recognition of Helicobacter pylori proteins are not concordant

1994 • 61 citations

Human monoclonal antibodies from stomach carcinoma patients react withhelicobacter pylori and stimulate stomach cancer cells in vitro

1994 • 54 citations

What Are the Specific Features ofHelicobacter pyloriGastritis in Children?

1995 • 54 citations

Macromolecular transport by rat gastric mucosa

1992 • 48 citations

A role for stem cell factor and c-kit in the murine intestinal tract secretory response to cholera toxin.

1995 • 46 citations

Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose.

1996 • 46 citations

Houseflies Are an Unlikely Reservoir or Vector for Helicobacter pylori

1998 • 40 citations

Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability.

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Regulation of autoimmune response

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Neutrophilic proteases: Mediators of formyl-methionyl-leucyl-phenylalanine-induced ileitis in rats

1989 • 37 citations

Sucrose Permeability in Children with Gastric Damage and Helicobacter pylori Infection

1997 • 36 citations

Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection

1995 • 29 citations

CANCER MORTALITY AMONG PUERTO RICAN-BORN RESIDENTS IN NEW YORK CITY1

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Evidence against an increased risk of Helicobacter pylori infection in dentists: a serological and salivary study.

1995 • 27 citations

Neutrophil-Epithelial Cell Interactions in the Intestine

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Letters to the Editors

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23 MACROPHAGE INFILTRATION OF THE GASTRIC MUCOSA IN CHILDREN WITH AND WITHOUT HELICOBACTER PYLORI INFECTION.

1996 • 6 citations