The Effect of Class II Major Histocompatibility Complex Expression on Adherence of Helicobacter pylori and Induction of Apoptosis in Gastric Epithelial Cells: A Mechanism for T Helper Cell Type 1–mediated Damage

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

1984 • 5,344 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

1996 • 1,883 citations

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

1995 • 1,613 citations

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.

1993 • 1,262 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis

1994 • 820 citations

Cytotoxic activity in broth-culture filtrates of Campylobacter pylori

1988 • 681 citations

Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology

1991 • 667 citations

Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype

1998 • 574 citations

Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.

1995 • 534 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease.

1997 • 485 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity

1996 • 427 citations

Induction of gastric epithelial apoptosis by Helicobacter pylori.

1996 • 425 citations

Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.

1995 • 360 citations

Helicobacter pylori cagA+ Strains and Dissociation of Gastric Epithelial Cell Proliferation From Apoptosis

1997 • 339 citations

Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa

1996 • 332 citations

Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa

1991 • 325 citations

Regulation of gastric epithelial cell growth by Helicobacter pylori: Offdence for a major role of apoptosis

1997 • 320 citations

Differential expression of bcl-2 in intestinal epithelia correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia

1995 • 308 citations

Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro

1995 • 288 citations

Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins.

1996 • 287 citations

Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45

1997 • 282 citations

Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection.

1997 • 276 citations

An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium.

1993 • 264 citations

Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.

1995 • 258 citations

Helicobacter Pylori and Gastroduodenal Disease

1992 • 257 citations

The Interrelationship between Cytotoxin-Associated Gene A, Vacuolating Cytotoxin, and Helicobacter pylori-Related Diseases

1996 • 256 citations

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen.

1995 • 248 citations

Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment.

1996 • 202 citations

Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa

1997 • 147 citations

Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation.

1994 • 135 citations

Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: potential role in CD4+ T cell activation during Helicobacter pylori infection.

1997 • 132 citations

The Human Gastrointestinal Secretory Immune System in Health and Disease

1985 • 124 citations

ヒトの胃の上皮細胞でのHelicobacter pylori細胞の系統特異的な親和性を表すことを示すin vitroでの付着解析

1993 • 121 citations

Association of Campylobacter pylori with induced expression of class II transplantation antigens on gastric epithelial cells

1989 • 121 citations

Apoptosis of monocytes and prolonged survival of granulocytes as a result of phagocytosis of bacteria

1996 • 118 citations

Ligation of major histocompatibility complex class II molecules mediates apoptotic cell death in resting B lymphocytes.

1993 • 116 citations

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

1993 • 110 citations

Comparison of Helicobacter pylori and attaching-effacing Escherichia coli adhesion to eukaryotic cells

1993 • 106 citations

MHC class II signaling in B-cell activation

1994 • 100 citations

Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies

1995 • 95 citations

Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis.

1996 • 82 citations

Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes.

1992 • 71 citations

Contact of lymphocytes with Helicobacter pylori augments natural killer cell activity and induces production of gamma interferon

1993 • 69 citations

Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains.

1991 • 68 citations

Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa.

1990 • 68 citations

Characterization of Hela cell vacuoles induced by Helicobacter pylori broth culture supernatant

1992 • 67 citations

Adherence of Helicobacter pylori to human gastric epithelial cells in vitro

1991 • 56 citations

Cathepsin B cleavage and release of invariant chain from MHC class II molecules follow A staged pattern

1994 • 41 citations

Adherence of Helicobacter pylori to Gastric Carcinoma Cells: Analysis by Flow Cytometry

1991 • 39 citations

The immunopathogenesis of gastroduodenal disease associated with Helicobacter pylori infection

1995 • 20 citations

Adherence and internalization of H. pylori by epithelial cells

1994 • 7 citations