Helicobacter pylori in Childhood: New Insights Into the Immunopathogenesis of Gastric Disease and Implications for Managing Infection in Children

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

1984 • 5,344 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.

1992 • 3,047 citations

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

1996 • 1,883 citations

Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma

1991 • 1,874 citations

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

1995 • 1,613 citations

Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.

1991 • 1,399 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

1995 • 965 citations

Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer

1998 • 956 citations

Cure of duodenal ulcer associated with eradication of Helicobacter pylori

1990 • 943 citations

The mucosal immune system: from fundamental concepts to vaccine development

1992 • 912 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

Helicobacter pyloriand Peptic Ulcer Disease

1991 • 673 citations

Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori

1998 • 618 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

Water source as risk factor for Helicobacter pylori infection in Peruvian children

1991 • 592 citations

Intrafamilial Clustering ofHelicobacter pyloriInfection

1990 • 582 citations

Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype

1998 • 574 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease.

1997 • 485 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

1992 • 450 citations

Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection.

1994 • 433 citations

Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity

1996 • 427 citations

Induction of gastric epithelial apoptosis by Helicobacter pylori.

1996 • 425 citations

Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.

1995 • 412 citations

Stomach Cancer Among Japanese in Hawaii<xref ref-type="fn" rid="FN2">2</xref>

1972 • 388 citations

Helicobacter pylori and gastric carcinoma: Serum antibody prevalence in populations with contrasting cancer risks

1990 • 382 citations

Helicobacter pylori: the African enigma.

1992 • 380 citations

Immunization of Mice with Urease Vaccine Affords Protection against Helicobacter pylori Infection in the Absence of Antibodies and Is Mediated by MHC Class II–restricted Responses

1998 • 378 citations

Parasitism by the "slow" bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia.

1994 • 377 citations

Helicobacter pylori Infection in Intestinal- and Diffuse-Type Gastric Adenocarcinomas

1991 • 366 citations

Association ofCampylobacter pylorion the Gastric Mucosa with Antral Gastritis in Children

1987 • 365 citations

HELICOBACTER PYLORI-SPECIFIC TUMOUR-INFILTRATING T CELLS PROVIDE CONTACT DEPENDENT HELP FOR THE GROWTH OF MALIGNANT B CELLS IN LOW-GRADE GASTRIC LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE

1996 • 352 citations

Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.

1994 • 349 citations

Helicobacter pylori cagA+ Strains and Dissociation of Gastric Epithelial Cell Proliferation From Apoptosis

1997 • 339 citations

Helicobacter pylori infection in the pathogenesis of duodenal ulcer and gastric cancer: A model

1997 • 338 citations

Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa

1996 • 332 citations

Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa

1991 • 325 citations

Regulation of gastric epithelial cell growth by Helicobacter pylori: Offdence for a major role of apoptosis

1997 • 320 citations

Helicobacter pylori in the drinking water in Peru

1996 • 308 citations

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

1993 • 294 citations

Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load

1997 • 292 citations

Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection.

1997 • 276 citations

Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis.

1995 • 258 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis.

1998 • 253 citations

Helicobacter pylori: Its Role in Disease

1992 • 251 citations

Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease

1994 • 248 citations

Helicobacter pylori isolated from the domestic cat: public health implications

1994 • 244 citations

Changes in the gastric mucosa following eradication of Helicobacter pylori.

1993 • 242 citations

Immune response of the gastric mucosa to Campylobacter pylori.

1988 • 235 citations

Patterns of gastro‐intestinal cancer in european migrants to Australia: The role of dietary change

1980 • 227 citations

Different cytokine profile and antigen‐specificity repertoire in Helicobacter pylori‐specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer

1997 • 213 citations

Meningiomas and Gliomas in Juxtaposition

1995 • 212 citations

The Effect of Class II Major Histocompatibility Complex Expression on Adherence of Helicobacter pylori and Induction of Apoptosis in Gastric Epithelial Cells: A Mechanism for T Helper Cell Type 1–mediated Damage

1998 • 202 citations

Helicobacter pylori in hispanics: Comparison with blacks and whites of similar age and socioeconomic class

1992 • 202 citations

Vector potential of houseflies (Musca domestica) for Helicobacter pylori

1997 • 185 citations

A Population-Based Serologic Survey of Helicobacter pylori Infection in Children and Adolescents in the United States

1996 • 177 citations

Book Review AIDS and Surgery Edited by Andrew J.W. Sim and Donald J. Jeffries. 144 pp., illustrated. Boston, Blackwell Scientific, 1990. $54.95.

1991 • 173 citations

Immune Response of the Gastric Mucosa toCampylobacter pylori

1988 • 168 citations

Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.

1995 • 165 citations

Antrum- and Corpus Mucosa-Infiltrating CD4⁺Lymphocytes inHelicobacter pyloriGastritis Display a Th1 Phenotype

1998 • 157 citations

Effect of eradication of Helicobacter pylori on gastric juice ascorbic acid concentrations.

1993 • 155 citations

Helicobacter pyloriInfection in Immunized Mice Lacking Major Histocompatibility Complex Class I and Class II Functions

1999 • 154 citations

Immunomagnetic separation and PCR for detection of Helicobacter pylori in water and stool specimens

1995 • 148 citations

Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa

1997 • 147 citations

Helicobacter pylori Infection in Recurrent Abdominal Pain in Childhood: Comparison of Diagnostic Tests and Therapy

1995 • 137 citations

Helicobacter pylori-negative duodenal ulcer.

1991 • 136 citations

Idiotype identity in a MALT-type lymphoma and B cells in Helicobacter pylori associated chronic gastritis.

1994 • 136 citations

Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation.

1994 • 135 citations

HELICOBACTER PYLORI IN THE PEDIATRIC PATIENT

1993 • 134 citations

Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment.

1994 • 131 citations

Bugs on trial: the case of Helicobacter pylori and autoimmunity

1998 • 128 citations

Effect of oral immunization with recombinant urease on murine Helicobacter felis gastritis

1995 • 122 citations

Fibroblasts modulate intestinal secretory responses to inflammatory mediators.

1992 • 120 citations

Long‐term follow‐up of gastric histology after Helicobacter pylori eradication

1996 • 113 citations

Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection

1998 • 106 citations

Urease-specific monoclonal antibodies prevent Helicobacter felis infection in mice

1995 • 98 citations

Carcinogenesis, apoptosis and cell proliferation

1998 • 92 citations

Helicobacter pylori-negative duodenal ulcer

1991 • 82 citations

National Cancer Institute Monograph 21

1966 • 78 citations

Helicobacter pyloriand Progressive Gastric Pathology that Predisposes to Gastric Cancer

1991 • 78 citations

Contact of lymphocytes with Helicobacter pylori augments natural killer cell activity and induces production of gamma interferon

1993 • 69 citations

Helicobacter pylori and associated duodenal ulcer.

1990 • 69 citations

Differential Normalization of Mucosal Interleukin-8 and Interleukin-6 Activity afterHelicobacter pyloriEradication

1998 • 67 citations

Helicobacter pylori infection and gastric juice vitamin C levels

1995 • 65 citations

Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis.

1997 • 63 citations

Humoral and cellular immune recognition of Helicobacter pylori proteins are not concordant

1994 • 61 citations

Quantitative distribution of immunoglobulin-producing cells in gastric mucosa: relation to chronic gastritis and glandular atrophy.

1986 • 56 citations

Human monoclonal antibodies from stomach carcinoma patients react withhelicobacter pylori and stimulate stomach cancer cells in vitro

1994 • 54 citations

What Are the Specific Features ofHelicobacter pyloriGastritis in Children?

1995 • 54 citations

Macromolecular transport by rat gastric mucosa

1992 • 48 citations

Effects of aspirin and Helicobacter pylori on the gastroduodenal mucosal permeability to sucrose.

1996 • 46 citations

Houseflies Are an Unlikely Reservoir or Vector for Helicobacter pylori

1998 • 40 citations

Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability.

1998 • 38 citations

Neutrophilic proteases: Mediators of formyl-methionyl-leucyl-phenylalanine-induced ileitis in rats

1989 • 37 citations

Sucrose Permeability in Children with Gastric Damage and Helicobacter pylori Infection

1997 • 36 citations

Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection

1995 • 29 citations

Oral Immunization: Turning Fantasy into Reality

1994 • 28 citations

Neutrophil-Epithelial Cell Interactions in the Intestine

1991 • 24 citations

The immunopathogenesis of gastroduodenal disease associated with Helicobacter pylori infection

1995 • 20 citations

Development of a vaccine

1995 • 13 citations

Differential diagnosis of jaundice a statistical algorithm

1983 • 7 citations

23 MACROPHAGE INFILTRATION OF THE GASTRIC MUCOSA IN CHILDREN WITH AND WITHOUT HELICOBACTER PYLORI INFECTION.

1996 • 6 citations