Regulation of autoimmune response

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

1981 • 520 citations

Vaccination Against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

1989 • 416 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

1990 • 370 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Role of CD8 ⁺ T Cells in Murine Experimental Allergic Encephalomyelitis

1992 • 351 citations

Regulation of apoptosis in the immune system

1994 • 321 citations

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

1990 • 312 citations

Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.

1993 • 305 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Amelioration of Autoimmune Encephalomyelitis by Myelin Basic Protein Synthetic Peptide-Induced Anergy

1992 • 251 citations

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

1994 • 229 citations

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis

1991 • 202 citations

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease.

1993 • 197 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1993 • 182 citations

Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.

1988 • 179 citations

Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor.

1993 • 170 citations

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

1991 • 165 citations

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1994 • 123 citations

Requirement for CD8⁺Cells in T Cell Receptor Peptide-Induced Clonal Unresponsiveness

1993 • 122 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Antigen-specific activation, tolerization, and reactivation of the interleukin 4 pathway in vivo.

1994 • 74 citations

Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide.

1993 • 64 citations

Treatment of PL/J mice with the superantigen, staphylococcal enterotoxin B, prevents development of experimental allergic encephalomyelitis

1993 • 54 citations

Superantigen-driven peripheral deletion of T cells. Apoptosis occurs in cells that have lost the alpha/beta T cell receptor.

1993 • 52 citations

Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes.

1993 • 49 citations

A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains

1992 • 47 citations

T-cell receptor peptide immunization leads to enhanced and chronic experimental allergic encephalomyelitis.

1991 • 45 citations

The induction of peripheral tolerance by the chronic activation and deletion of CD4+V beta 5+ cells.

1994 • 45 citations

Loss rather than downregulation of CD4+ T cells as a mechanism for remission from experimental allergic encephalomyelitis

1993 • 36 citations

T cell responses to myelin basic protein in experimental autoimmune encephalomyelitis-resistant BALB/c mice

1993 • 31 citations

SEB induced anergy: modulation of immune response to T cell determinants of myoglobin and myelin basic protein.

1993 • 30 citations

Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides

1993 • 28 citations

EVIDENCE THAT CLONAL ANERGY IS INDUCED IN THYMIC MIGRANT CELLS AFTER ANTI-CD4-MEDIATED TRANSPLANTATION TOLERANCE

1993 • 27 citations

Vaccination with T cell receptor peptides primes anti‐receptor cytotoxic T lymphocytes (CTL) and anergizes T cells specifically recognized by these CTL

1994 • 21 citations

Modulation of EAE by vaccination with T cell receptor peptides: Vβ8 T cell receptor peptide-specific CD4+ lymphocytes lack direct immunoregulatory activity

1993 • 14 citations

Autoantigenic peptide therapy in experimental autoimmune encephalomyelitis.

1993 • 3 citations