Polymorphic variation inhOGG1 and risk of cancer: A review of the functional and epidemiologic literature

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

2004 • 1,720 citations

Quality Control by DNA Repair

1999 • 1,469 citations

Polymorphisms in DNA repair genes and associations with cancer risk.

2002 • 1,199 citations

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

1996 • 607 citations

RESPONSE Re: Markers of DNA Repair and Susceptibility to Cancer in Humans: an Epidemiologic Review

2000 • 556 citations

Two Pathways for Base Excision Repair in Mammalian Cells

1996 • 520 citations

Markers of DNA Repair and Susceptibility to Cancer in Humans: an Epidemiologic Review

2000 • 496 citations

Base Excision Repair Is Impaired in Mammalian Cells Lacking Poly(ADP-ribose) Polymerase-1

2000 • 487 citations

The Human OGG1 Gene: Structure, Functions, and Its Implication in the Process of Carcinogenesis

2000 • 460 citations

Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

1998 • 441 citations

Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes.

1998 • 408 citations

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1997 • 316 citations

Cigarette smoking induces an increase in oxidative DNA damage, 8- hydroxydeoxyguanosine, in a central site of the human lung

1997 • 289 citations

Wine intake and diet in a random sample of 48763 Danish men and women

1999 • 287 citations

DNA Repair Activity for Oxidative Damage and Risk of Lung Cancer

2003 • 282 citations

Urinary 8-hydroxydeoxyguanosine and its analogs as DNA marker of oxidative stress: development of an ELISA and measurement in both bladder and prostate cancers

2003 • 271 citations

Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage

1997 • 258 citations

Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations

1999 • 254 citations

Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking.

1996 • 253 citations

Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA

1995 • 247 citations

Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk.

2002 • 235 citations

hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.

1999 • 233 citations

Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?

1998 • 232 citations

Role of DNA Polymerase β in the Excision Step of Long Patch Mammalian Base Excision Repair

1999 • 221 citations

Inactivation of OGG1 increases the incidence of G · C→T · A transversions in Saccharomyces cerevisiae : evidence for endogenous oxidative damage to DNA in eukaryotic cells

1997 • 217 citations

Determination of 8-Oxoguanine in DNA by Gas Chromatography-Mass Spectrometry and HPLC-Electrochemical Detection: Overestimation of the Background Level of the Oxidized Base by the Gas Chromatography-Mass Spectrometry Assay

1995 • 204 citations

Endogenous oxidative damage of mtDNA

1999 • 199 citations

Challenges and complexities in estimating both the functional impact and the disease risk associated with the extensive genetic variation in human DNA repair genes

2003 • 199 citations

The history of biological warfare

2003 • 193 citations

Problems in the measurement of 8-oxoguanine in human DNA. Report of a workshop, DNA oxidation, held in Aberdeen, UK, 19-21 January, 1997

1997 • 189 citations

The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk

2002 • 182 citations

Reconstitution of Proliferating Cell Nuclear Antigen-dependent Repair of Apurinic/Apyrimidinic Sites with Purified Human Proteins

1999 • 177 citations

Human DNA polymerase β initiates DNA synthesis during long-patch repair of reduced AP sites in DNA

2001 • 176 citations

The genotype distribution of the XRCC1gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia

2002 • 175 citations

Associations between hOGG1 sequence variants and prostate cancer susceptibility.

2002 • 172 citations

hOGG1 polymorphism and loss of heterozygosity (LOH): Significance for lung cancer susceptibility in a caucasian population

2000 • 163 citations

Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions

2004 • 158 citations

Ser326Cys polymorphism inhOGG1 gene and risk of esophageal cancer in a Chinese population

2001 • 153 citations

Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1.

2003 • 153 citations

Human DNA repair genes

2001 • 151 citations

Choreography of oxidative damage repair in mammalian genomes1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

2002 • 145 citations

Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo

2004 • 135 citations

Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility.

2002 • 126 citations

DNA repair activity of 8-oxoguanine DNA glycosylase 1 (OGG1) in human lymphocytes is not dependent on genetic polymorphism Ser326/Cys326

2001 • 125 citations

Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells

1995 • 125 citations

Comparison of analyses of urinary 8‐hydroxy‐2′‐deoxyguanosine by isotope‐dilution liquid chromatography with electrospray tandem mass spectrometry and by enzyme‐linked immunosorbent assay

2004 • 116 citations

Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein

2000 • 116 citations

Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung.

1992 • 107 citations

HOGG1 Ser³²⁶Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese

2002 • 107 citations

Overexpression of the hOGG1 gene and high 8-hydroxy-2'-deoxyguanosine (8-OHdG) lyase activity in human colorectal carcinoma: regulation mechanism of the 8-OHdG level in DNA.

2000 • 105 citations

The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk

2004 • 104 citations

Infrequent Mutations of the hOGG1 Gene, That Is Involved in the Excision of 8‐Hydroxyguanine in Damaged DNA, in Human Gastric Cancer

1998 • 101 citations

hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer

2003 • 99 citations

Association Between Polymorphism of Human Oxoguanine Glycosylase 1 and Risk of Prostate Cancer

2003 • 97 citations

Reconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteins

2002 • 94 citations

Age-associated Decrease of Oxidative Repair Enzymes, Human 8-Oxoguanine DNA Glycosylases (hOgg1), in Human Aging

2003 • 90 citations

The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer

2000 • 89 citations

Symposium Overview: Genetic Polymorphisms in DNA Repair and Cancer Risk

2002 • 83 citations

A Limited Association of OGG1 Ser326Cys Polymorphism for Adenocarcinoma of the Lung.

2002 • 80 citations

DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer

2002 • 78 citations

Long‐patch DNA repair synthesis during base excision repair in mammalian cells

2003 • 78 citations

Oxidative DNA damage and 8‐hydroxy‐2‐deoxyguanosine DNA glycosylase/apurinic lyase in human breast cancer

2001 • 72 citations

No association between OGG1 Ser326Cys polymorphism and breast cancer risk.

2003 • 71 citations

New DNA polymorphisms of humanMMH/OGG1 gene: Prevalence of one polymorphism among lung-adenocarcinoma patients in Japanese

1999 • 69 citations

Lung Cancer Patients Have Increased 8‐Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA

1998 • 66 citations

hOGG1 exon7 polymorphism and gastric cancer in case–control studies of Japanese Brazilians and non-Japanese Brazilians

2001 • 63 citations

Molecular epidemiology in cancer research

1998 • 59 citations

hOGG1 Ser 326 Cys Polymorphism and Breast Cancer Risk among Asian Women

2003 • 57 citations

Frequent allelic loss at chromosome 3p distinct from genetic alterations of the 8-oxoguanine DNA glycosylase 1 gene in head and neck cancer

1999 • 55 citations

Impaired DNA-repair synthesis in lymphocytes of breast cancer patients

1986 • 55 citations

Effect of Human OGG1 1245C→G Gene Polymorphism on 8-Hydroxy-2′-Deoxyguanosine Levels of Leukocyte DNA among Patients Undergoing Chronic Hemodialysis

2001 • 47 citations

Construction of mutants of Salmonella typhimurium deficient in 8-hydroxyguanine DNA glycosylase and their sensitivities to oxidative mutagens and nitro compounds

1997 • 42 citations

Genetic changes of hOGG1 and the activity of oh8Gua glycosylase in colon cancer

2001 • 41 citations

Detection of Oxidative Base DNA Damage by a New Biochemical Assay

2000 • 39 citations

Mode of Inhibition of Short-patch Base Excision Repair by Thymine Glycol within Clustered DNA Lesions

2003 • 34 citations

No Association between hOGG1 Ser326Cys Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck

2004 • 33 citations

Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines.

2002 • 33 citations

Methodological considerations and factors affecting 8-hydroxy-2′-deoxyguanosine analysis

1998 • 31 citations

Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells.

2000 • 27 citations

Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG₁: A study of adolescents in a high risk region for hepatocellular carcinoma in China

2003 • 25 citations

Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells

2003 • 19 citations