Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

1994 • 1,319 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

2000 • 671 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

Bleomycin: New Perspectives on the Mechanism of Action

1999 • 522 citations

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

2001 • 490 citations

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

2000 • 461 citations

Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations

2000 • 440 citations

XRCC1 keeps DNA from getting stranded

2000 • 440 citations

Genetic polymorphisms in DNA repair genes and risk of lung cancer

2001 • 323 citations

Sensitivity to genotoxic effects of bleomycin in humans: Possible relationship to environmental carcinogenesis

1989 • 321 citations

Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck

1999 • 317 citations

Genetic Polymorphisms of HumanN-Acetyltransferase, Cytochrome P450, Glutathione-S-Transferase, and Epoxide Hydrolase Enzymes: Relevance to Xenobiotic Metabolism and Toxicity

1999 • 303 citations

Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect

1996 • 301 citations

SHORT COMMUNICATION: Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans

1993 • 293 citations

Biochemical genetics of glutathione-s-transferase in man

1981 • 248 citations

Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.

1995 • 241 citations

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.

2001 • 236 citations

Polymorphisms In The DNA Repair Gene Xrcc1 And Breast Cancer

2001 • 235 citations

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

2001 • 225 citations

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK

2000 • 207 citations

Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk.

2001 • 188 citations

Glutathione S-Transferase and N-Acetyltransferase Genotypes and Asbestos-Associated Pulmonary Disorders

1996 • 144 citations

Role of GSTT1and GSTM1genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes

1995 • 137 citations

The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells

1999 • 124 citations

Inherited Susceptibility to Bleomycin-Induced Chromatid Breaks in Cultured Peripheral Blood Lymphocytes

1999 • 124 citations

Human Bleomycin Hydrolase: Molecular Cloning, Sequencing, Functional Expression, and Enzymatic Characterization

1996 • 107 citations

A BLEOMYCIN-INACTIVATING ENZYME IN MOUSE LIVER

1974 • 99 citations

Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes

1995 • 77 citations

A case-control study of wood dust exposure, mutagen sensitivity, and lung cancer risk.

1995 • 72 citations

Mutagen sensitivity as a susceptibility marker for human hepatocellular carcinoma.

1998 • 59 citations

Metabolic inactivation: a mechanism of human tumor resistance to bleomycin.

1991 • 57 citations

Individual sensitivity to cytogenetic effects of 1,2

1998 • 55 citations

Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance.

1996 • 52 citations

Multiple regression analysis of cytogenetic human data

1994 • 40 citations

Variant metabolizing gene alleles determine the genotoxicity of benzo[a]pyrene

2001 • 39 citations

Induction of sister chromatid exchange by 1,2-epoxy-3-butene in cultured human lymphocytes: influence of GSTT1 genotype

1998 • 39 citations

Role of polymorphic GSTM1 and GSTT1 genotypes on NNK-induced genotoxicity

1999 • 38 citations

Inactivation of bleomycin by anN-acetyltransferase in the bleomycin-producing strainStreptomyces verticillus

1994 • 38 citations

Influence ofGSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes

1998 • 38 citations

Essential Binding and Functional Domains of Human Bleomycin Hydrolase

1998 • 32 citations

Mutagen sensitivity as a marker of cancer risk.

1994 • 27 citations

The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.

1991 • 20 citations

Production of bleomycin N-acetyltransferase in Escherichia coli and Streptomyces verticillus

2006 • 20 citations

Three Measures of Mutagen Sensitivity in a Cancer-Free Population

1999 • 19 citations

Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes

2001 • 11 citations

The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage

1998 • 11 citations

A Mammalian Vector Carrying the Bleomycin N-Acetyltransferase Gene from Bleomycin-producing Streptomyces verticillus as a Selective Marker.

1999 • 5 citations