Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

1996 • 775 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

1996 • 607 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

1990 • 403 citations

Colorectal cancer in Egyptian patients under 40 years of age

1997 • 120 citations

Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and XRCC1, on human chromosome 19

1989 • 101 citations

Evidence of anti-benzo[a]pyrene diolepoxide-DNA adduct formation in human colon mucosa

1996 • 89 citations

The role of DNA repair capacity in susceptibility to lung cancer: a review.

1997 • 84 citations

Review of studies of selected metabolic polymorphisms and cancer.

1999 • 83 citations

Serum Organochlorine Pesticide Levels in Patients with Colorectal Cancer in Egypt

1997 • 76 citations

High levels of DNA adducts in human colon are associated with colorectal cancer.

1995 • 69 citations

Correlates of mutagen sensitivity in patients with upper aerodigestive tract cancer.

1997 • 59 citations

Molecular interaction of [2,3‐¹⁴C] acrylonitrile with DNA in gastric tissue of rat

1994 • 48 citations

Petroleum and chlorinated hydrocarbons in water from Lake Manzala and associated canals

1995 • 47 citations

Cytogenetic effects in a group of traffic policemen in Cairo

1988 • 45 citations

DNA-mediated transfer of a human DNA repair gene that controls sister chromatid exchange.

1985 • 45 citations

Epidemiology of ultraviolet-DNA repair capacity and human cancer.

1997 • 32 citations

Familial aggregation of colorectal cancer in Egypt

1998 • 32 citations

Residue levels of chlorinated hydrocarbon compounds in water and sediment samples from Nile branches in the delta, Egypt

1991 • 31 citations

Polymorphism of glutathione S-transferase loci GSTM1 and GSTT1 and susceptibility to colorectal cancer in Egypt

1999 • 31 citations

Assessment of Lead Toxicity in Traffic Controllers of Alexandria, Egypt, Road Intersections

1987 • 26 citations

Assessment of cytogenetic changes in human populations at risk in Egypt

1994 • 26 citations

Cancer mortality in Menofeia, Egypt: comparison with US mortality rates.

1999 • 25 citations

Organo-chlorine insecticides and PCBs in River Nile water, Egypt

1985 • 24 citations

Monitoring of human populations at risk by different cytogenetic end points.

1994 • 24 citations

Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt.

1998 • 23 citations

Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease [published erratum appears in Toxicol Sci 1999 Oct;51(2):317]

1999 • 21 citations

Inhibition of S‐(1,2‐dichlorovinyl)‐L‐cysteine‐induced lipid peroxidation by antioxidants in rabbit renal cortical slices: Dissociation of lipid peroxidation and toxicity

1994 • 14 citations

Monitoring of Human Populations at Risk by Different Cytogenetic End Points

1994 • 9 citations