A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma.

Pancreatic Cancer

2000 • 7,332 citations

Cancer Statistics, 2001

2001 • 3,342 citations

Estimates of the worldwide incidence of 25 major cancers in 1990

1999 • 2,103 citations

Quality Control by DNA Repair

1999 • 1,469 citations

XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

1998 • 900 citations

CONCEPTS OF INTERACTION

1980 • 830 citations

Trends in Cancer Incidence, Survival and Mortality

2009 • 785 citations

Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans.

1998 • 775 citations

Physical Activity, Obesity, Height, and the Risk of Pancreatic Cancer

2001 • 653 citations

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

1996 • 607 citations

XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair

2001 • 594 citations

XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.

1999 • 575 citations

RESPONSE Re: Markers of DNA Repair and Susceptibility to Cancer in Humans: an Epidemiologic Review

2000 • 556 citations

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

2000 • 532 citations

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

1997 • 525 citations

Repair of Tobacco Carcinogen-Induced DNA Adducts and Lung Cancer Risk: a Molecular Epidemiologic Study

2000 • 513 citations

XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32P-DNA adducts in a sample of healthy subjects

2001 • 490 citations

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

1994 • 477 citations

Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells

2000 • 461 citations

XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions

2001 • 454 citations

Population Stratification in Epidemiologic Studies of Common Genetic Variants and Cancer: Quantification of Bias

2000 • 445 citations

Abnormal Glucose Metabolism and Pancreatic Cancer Mortality

2000 • 412 citations

Correlates of Markers of Oxidative Status in the General Population

2001 • 349 citations

Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity

2001 • 345 citations

Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck

1999 • 317 citations

A Prospective Study of Cigarette Smoking and the Risk of Pancreatic Cancer

1996 • 306 citations

DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study

2001 • 299 citations

Blased Tests of Association: Comparisons of Allele Frequencies when Departing from Hardy-Weinberg Proportions

1999 • 265 citations

Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis.

1995 • 241 citations

DNA repair gene XRCC1 polymorphisms, smoking, and bladder cancer risk.

2001 • 236 citations

The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung

2001 • 225 citations

Polymorphisms of the DNA repair geneXRCC1 and risk of gastric cancer in a Chinese population

2000 • 207 citations

The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK

2000 • 207 citations

Base excision repair in a network of defence and tolerance

2001 • 196 citations

Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt

2000 • 195 citations

Sex-Specific Expression of Gastrin-Releasing Peptide Receptor: Relationship to Smoking History and Risk of Lung Cancer

2000 • 190 citations

The effect of dietary-induced obesity on lipid peroxidation, antioxidant enzymes and total plasma antioxidant capacity.

2000 • 172 citations

The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction.

2002 • 156 citations

A Population-Based, Case-Control Study of Polymorphisms in Carcinogen-Metabolizing Genes, Smoking, and Pancreatic Adenocarcinoma Risk

2002 • 150 citations

Risk factors for pancreatic cancer: A case-control study based on direct interviews

2000 • 134 citations

Free radical production in nicotine treated pancreatic tissue

1995 • 133 citations

Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage.

1990 • 131 citations

Genetic polymorphisms ofXRCC1 and risk of the esophageal cancer

2001 • 127 citations

Smoking and pancreatic cancer in men and women.

1997 • 113 citations

Internal hazards: baseline DNA damage by endogenous products of normal metabolism

1999 • 111 citations

Physical activity, anthropometric factors and risk of pancreatic cancer: Results from the Canadian enhanced cancer surveillance system

2001 • 107 citations

Occurrence, trends and environmental etiology of pancreatic cancer

1998 • 106 citations

Comparison of DNA adduct levels associated with oxidative stress in human pancreas

1998 • 103 citations

A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trøndelag, Norway.

2000 • 102 citations

Metabolic activation of aromatic amines by human pancreas

1997 • 97 citations

DNA adducts in human pancreatic tissues and their potential role in carcinogenesis.

1998 • 77 citations

High-throughput SNP genotyping with the Masscode system.

2000 • 71 citations

Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression

2001 • 68 citations

The BRCT Regions of Tumor Suppressor BRCA1 and of XRCC1 Show DNA End Binding Activity with a Multimerizing Feature

2000 • 60 citations

Gender differences in autoantibodies to oxidative DNA base damage in cigarette smokers.

2001 • 51 citations

Smoking and pancreatic disorders

2000 • 49 citations

Comparison of DNA adduct levels associated with exogenous and endogenous exposures in human pancreas in relation to metabolic genotype

1999 • 41 citations

Individual susceptibility to induced chromosome damage and its implications for detecting genotoxic exposures in human populations.

1991 • 41 citations

Effects of sex and age on pancreatic secretion

1986 • 34 citations

Hormones and pancreatic cancer

1991 • 32 citations

Estrogen effects on exocrine pancreatic secretion in menopausal women: a hypothesis for menopause-induced chronic pancreatitis.

1986 • 14 citations