Mechanism of Signal Transduction by the basic Helix-Loop-Helix Dioxin Receptor

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)

1990 • 1,872 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes

1984 • 1,066 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

1993 • 1,019 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

1989 • 861 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 • 769 citations

Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain

1993 • 723 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

1994 • 686 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Transcriptional Activation Modulated by Homopolymeric Glutamine and Proline Stretches

1994 • 598 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1991 • 576 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

Cell Growth & Differentiation

1992 • 558 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

Hsp90 chaperones protein folding in vitro

1992 • 514 citations

Steroid receptors and their associated proteins.

1993 • 513 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene

1991 • 499 citations

TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.

1990 • 484 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

HLH proteins, fly neurogenesis, and vertebrate myogenesis

1993 • 420 citations

cDNA cloning and structure of mouse putative Ah receptor

1992 • 406 citations

opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster

1985 • 404 citations

Evidence That the 90-kDa Heat Shock Protein Is Necessary for the Steroid Binding Conformation of the L Cell Glucocorticoid Receptor

1989 • 394 citations

Structure and function of the b/HLH/Z domain of USF.

1994 • 390 citations

Mechanistic aspects of dioxin action

1993 • 372 citations

Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy

1990 • 340 citations

Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.

1987 • 340 citations

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 • 336 citations

Cloning and expression of a human Ah receptor cDNA.

1993 • 334 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

The Ah receptor and the mechanism of dioxin toxicity

1991 • 330 citations

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

1990 • 330 citations

Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements

1987 • 323 citations

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

1994 • 308 citations

The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1992 • 308 citations

Helix-loop-helix proteins as regulators of muscle-specific transcription.

1993 • 293 citations

Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.

1988 • 268 citations

Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity.

1992 • 242 citations

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

1993 • 239 citations

Association of the dioxin receptor with the Mr 90,000 heat shock protein: A structural kinship with the glucocorticoid receptor

1988 • 234 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

Biological Basis for Risk Assessment of Dioxins and Related Compounds

1991 • 212 citations

Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.

1993 • 207 citations

The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

1990 • 204 citations

Isolation of Hsp90 mutants by screening for decreased steroid receptor function.

1993 • 201 citations

A DNA-binding factor specific for xenobiotic responsive elements of P-450c gene exists as a cryptic form in cytoplasm: its possible translocation to nucleus.

1988 • 198 citations

Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.

1993 • 192 citations

Requirement of hormone for thermal conversion of the glucocorticoid receptor to a DNA-binding state

1988 • 186 citations

Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1.

1990 • 165 citations

Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.

1993 • 161 citations

Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones.

1982 • 160 citations

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation.

1992 • 156 citations

Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84).

1992 • 155 citations

Cross-coupling of signal transduction pathways: the dioxin receptor mediates induction of cytochrome P-450IA1 expression via a protein kinase C-dependent mechanism.

1993 • 154 citations

A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and Arnt.

1993 • 150 citations

Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver.

1985 • 145 citations

Photoaffinity labeling of the Ah receptor.

1986 • 139 citations

The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein.

1987 • 139 citations

A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.

1994 • 134 citations

Regulation of Mouse CYP1A1 Gene Expression by Dioxin: Requirement of Two cis-Acting Elements during Induction

1989 • 126 citations

Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.

1992 • 126 citations

Dominant and recessive aryl hydrocarbon hydroxylase-deficient mutants of mouse hepatoma line, Hepa-1, and assignment of recessive mutants to three complementation groups

1983 • 124 citations

Chloracne, "the hallmark of dioxin intoxication".

1985 • 123 citations

Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.

1990 • 117 citations

Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity.

1989 • 111 citations

Regulation of CYP1A1 expression

1992 • 104 citations

Inhibition of the specific DNA binding activity of the dioxin receptor by phosphatase treatment.

1991 • 104 citations

The transformed glucocorticoid receptor has a lower steroid-binding affinity than the nontransformed receptor

1990 • 103 citations

Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1992 • 96 citations

Structural and functional aspects of basic helix-loop-helix protein folding by heat-shock protein 90.

1994 • 88 citations

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

1992 • 85 citations

Dioxin- and Ah receptor-dependent protein binding to xenobiotic responsive elements and G-rich DNA studied by in vivo footprinting.

1992 • 82 citations

Circadian Clock Genes Are Ticking

1992 • 79 citations

A new bind for Myc

1992 • 79 citations

High affinity DNA-binding Myc analogs: Recognition by an α helix

1993 • 75 citations

Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten.

1991 • 74 citations

Regulation of mouse CYP1A1 gene expression by dioxin: requirement of two cis-acting elements during induction.

1989 • 72 citations

Nonresponsiveness of normal human fibroblasts to dioxin correlates with the presence of a constitutive xenobiotic response element-binding factor.

1993 • 71 citations

Polyanionic-binding properties of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. A comparison with the glucocorticoid receptor.

1986 • 63 citations

Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element.

1993 • 60 citations

Purification of the DNA binding form of dioxin receptor. Role of the Arnt cofactor in regulation of dioxin receptor function.

1994 • 59 citations

Mechanism of dioxin action: receptor-enhancer interactions in intact cells

1993 • 59 citations

Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

1991 • 51 citations

Activation of the dioxin and glucocorticoid receptors to a DNA binding state under cell-free conditions.

1990 • 51 citations

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

1992 • 51 citations

Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes.

1990 • 50 citations

Interactions of rutaecarpine alkaloids with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver

1989 • 49 citations

Regulation of human dioxin receptor function by indolocarbazoles, receptor ligands of dietary origin.

1994 • 40 citations

Comparison of the nuclear and cytosolic forms of the Ah receptor from Hepa 1c1c7 cells: Charge heterogeneity and ATP binding properties

1991 • 38 citations

A cellular factor stimulates the DNA-binding activity of MyoD and E47.

1993 • 34 citations

Intracellular location of the Ah receptor

1986 • 32 citations

Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogeneity by two-dimensional gel electrophoresis

1990 • 30 citations

A new bind for Myc

1992 • 30 citations

In vitro activation of the dioxin receptor to a DNA-binding form by food-borne heterocyclic amines

1992 • 29 citations

Human Ah receptor cDNA: analysis for highly conserved sequences

1993 • 17 citations