The PAS domain confers target gene specificity of DrosophilabHLH/PAS proteins

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

1993 • 1,441 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

1992 • 830 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system

1993 • 529 citations

PAS is a dimerization domain common to Drosophila Period and several transcription factors

1993 • 515 citations

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

1991 • 501 citations

The midline of the drosophila central nervous system: A model for the genetic analysis of cell fate, cell migration, and growth cone guidance

1991 • 497 citations

Structure and function of helix-loop-helix proteins

1994 • 496 citations

breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

1992 • 419 citations

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.

1993 • 411 citations

The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

1992 • 324 citations

Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization

1991 • 312 citations

trachealess encodes a bHLH-PAS protein that is an inducer of tracheal cell fates in Drosophila.

1996 • 264 citations

Tubulogenesis in Drosophila: a requirement for the trachealess gene product.

1996 • 264 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

Expression Patterns of Two Murine Homologs ofDrosophila Single-MindedSuggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome

1996 • 198 citations

Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex.

1995 • 187 citations

Expression Patterns of Two Murine Homologs ofDrosophila Single-MindedSuggest Possible Roles in Embryonic Patterning and in the Pathogenesis of Down Syndrome

1996 • 161 citations

Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements.

1994 • 100 citations

Control of CNS midline transcription by asymmetric E-box-like elements: similarity to xenobiotic responsive regulation

1994 • 97 citations

The Drosophila melanogaster similar bHLH-PAS gene encodes a protein related to human hypoxia-inducible factor 1α and Drosophila single-minded

1996 • 87 citations

Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF‐1 binding sites

1996 • 59 citations

The Breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration

1995 • 55 citations

Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: Evidence for two distinct heteromeric DNA-binding forms

1993 • 45 citations

Transcriptional activation domains of the single-minded bHLH protein are required for CNS midline cell development

1994 • 41 citations