Active Mammalian Replication Origins Are Associated with a High-Density Cluster of ^mCpG Dinucleotides

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

DNA methylation and gene activity

1988 • 904 citations

Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

1992 • 502 citations

E. coli oriC and the dnaA gene promoter are sequestered from dam methyltransferase following the passage of the chromosomal replication fork

1990 • 464 citations

A lamin-independent pathway for nuclear envelope assembly.

1990 • 350 citations

DNA replication in eukaryotic cells

1997 • 346 citations

DNA Methylation Specifies Chromosomal Localization of MeCP2

1996 • 343 citations

Transition in Specification of Embryonic Metazoan DNA Replication Origins

1995 • 321 citations

PROKARYOTIC DNA REPLICATION

1992 • 319 citations

Role of DNA methylation in the regulation of transcription

1994 • 318 citations

Structure and Function of DNA Methyltransferases

1995 • 310 citations

Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.

1995 • 301 citations

E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration

1995 • 288 citations

Identification of an origin of bidirectional DNA replication in mammalian chromosomes

1990 • 288 citations

EUKARYOTIC DNA REPLICATION: Anatomy of An Origin

1993 • 280 citations

Replication structure of the human & beta;-globin gene domain

1993 • 277 citations

The distribution of CpG islands in mammalian chromosomes

1994 • 254 citations

Mapping replication units in animal cells

1989 • 232 citations

Hemimethylation prevents DNA replication in E. coli

1987 • 227 citations

Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication

1995 • 217 citations

Origins of DNA replication in metazoan chromosomes.

1993 • 203 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

Fine mapping of a replication origin of human DNA.

1994 • 193 citations

DNA methylation. The effect of minor bases on DNA-protein interactions

1990 • 181 citations

CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

1992 • 168 citations

Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.

1986 • 157 citations

Pattern of methylation of two genes coding for housekeeping functions.

1983 • 148 citations

Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation.

1991 • 140 citations

Growth regulation of mouse DNA methyltransferase gene expression

1991 • 137 citations

High-resolution mapping of replication fork movement through the amplified dihydrofolate reductase domain in CHO cells by in-gel renaturation analysis.

1989 • 134 citations

DNA Methylation from Embryo to Adult

1994 • 130 citations

Replication in the amplified dihydrofolate reductase domain in CHO cells may initiate at two distinct sites, one of which is a repetitive sequence element.

1989 • 130 citations

Mapping an origin of DNA replication at a single-copy locus in exponentially proliferating mammalian cells.

1990 • 128 citations

The majority of methylated deoxycytidines in human DNA are not in the CpG dinucleotide

1987 • 128 citations

Site-Specific Initiation of DNA Replication in Xenopus Egg Extract Requires Nuclear Structure

1995 • 123 citations

A Distinct G ₁ Step Required to Specify the Chinese Hamster DHFR Replication Origin

1996 • 123 citations

Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

1986 • 116 citations

CpG islands of chicken are concentrated on microchromosomes

1996 • 115 citations

A protein that binds to the P1 origin core and the oriC 13mer region in a methylation-specific fashion is the product of the host seqA gene.

1995 • 113 citations

Drosophila chorion genes: Cracking the eggshell's secrets

1991 • 109 citations

Nuclei that lack a lamina accumulate karyophilic proteins and assemble a nuclear matrix

1993 • 108 citations

The Chinese Hamster Dihydrofolate Reductase Origin Consists of Multiple Potential Nascent-Strand Start Sites

1995 • 103 citations

Replication of purified DNA in Xenopus egg extract is dependent on nuclear assembly

1990 • 100 citations

Rapid and quantitative recovery of DNA fragments from gels by displacement electrophoresis (isotachophoresis)

1984 • 96 citations

Autonomous Replication in Human Cells of Multimers of Specific Human and Bacterial DNA Sequences

1993 • 87 citations

Regulation of mouse satellite DNA replication time.

1988 • 84 citations

Methylation analysis on individual chromosomes: improved protocol for bisulphite genomic sequencing

1994 • 83 citations

High-Resolution Mapping of the Origin of DNA Replication in the Hamster Dihydrofolate Reductase Gene Domain by Competitive PCR

1996 • 81 citations

Localization and DNA sequence of a replication origin in the rhodopsin gene locus of Chinese hamster cells

1992 • 76 citations

Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse

1990 • 75 citations

Mapping of Replication Initiation Sites in Human Ribosomal DNA by Nascent-Strand Abundance Analysis

1995 • 67 citations

Densely methylated DNA islands in mammalian chromosomal replication origins.

1994 • 59 citations

Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci.

1993 • 58 citations

2 Origins of DNA Replication

1996 • 58 citations

In VitroReplication of Plasmids Containing Human c-mycDNA

1995 • 57 citations

Origins of DNA replication that function in eukaryotic cells

1993 • 55 citations

Replication initiation sites are distributed widely in the amplified CHO dihydrofolate reductase domain

1994 • 54 citations

DNA replication in cell-free extracts from Xenopus eggs is prevented by disrupting nuclear envelope function

1992 • 53 citations

TheoriCunwinding bydammethylation inEscherichia coli

1988 • 48 citations

Methylation of cytosine in the 5-position alters the structural and energetic properties of the supercoil-induced Z-helix and B-Z junctions

1988 • 48 citations

Replication intermediates formed during initiation of DNA synthesis in methotrexate-resistant CHOC 400 cells are enriched for sequences derived from a specific, amplified restriction fragment

1986 • 45 citations

Analysis of a replication initiation sequence from the adenosine deaminase region of the mouse genome.

1993 • 45 citations

Base methylation and local DNA helix stability

1989 • 41 citations

Nuclear DNA synthesis in vitro is mediated via stable replication forks assembled in a temporally specific fashion in vivo.

1988 • 40 citations

Identification of an Origin of Bidirectional DNA Replication in the Ubiquitously Expressed Mammalian CAD Gene

1995 • 39 citations

Mapping of replication initiation sites in the mouse ribosomal gene cluster

1996 • 38 citations

A Mammalian Origin of Bidirectional DNA Replication within the Chinese HamsterRPS14Locust

1994 • 38 citations

Only the promoter region of the constitutively expressed normal and amplified human dihydrofolate reductase gene is DNase I hypersensitive and undermethylated.

1985 • 34 citations

Methylation strongly enhances DNA bending in the replication origin region of the Escherichia coli chromosome

1989 • 32 citations

Delayed DNA methylation is an integral feature of DNA replication in mammalian cells

1986 • 28 citations

Mapping of replication initiation sites in the mouse ribosomal gene cluster

1996 • 27 citations

Cis-Acting Effects of Sequences Within 2.4-kb Upstream of the Human c-mycGene on Autonomous Plasmid Replication in HeLa Cells

1995 • 24 citations

Site-specific Initiation of DNA Replication in Metazoan Chromosomes and the Role of Nuclear Organization

1993 • 24 citations

A mammalian origin of bidirectional DNA replication within the Chinese hamster RPS14 locus.

1994 • 23 citations

Absence of an Unusual “Densely Methylated Island” at the Hamster dhfr ori-β

1997 • 23 citations

ors12, a mammalian autonomously replicating DNA sequence, associates with the nuclear matrix in a cell cycle-dependent manner

1993 • 22 citations

Analysis of a Replication Initiation Sequence from the Adenosine Deaminase Region of the Mouse Genome

1993 • 18 citations

Intracellular distribution of DNA methyltransferase during the cell cycle

1988 • 18 citations

Methylation of Mouse Ribosomal RNA Genes

1982 • 17 citations

Methylation is co-ordinated on the putative replication origins of Physarum ribosomal DNA

1988 • 16 citations

A densely methylated DNA Island is associated with a chromosomal replication origin in the humanRPS14 locus

1995 • 15 citations

Asynchronous DNA replication between 15q11.2q12 homologs: cytogenetic evidence for maternal imprinting and delayed replication

1995 • 12 citations