Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis

1983 • 1,681 citations

The Alu Family of Dispersed Repetitive Sequences

1982 • 611 citations

New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase α

1981 • 389 citations

The Mechanism of Action of Inhibitors of DNA Synthesis

1977 • 330 citations

Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region

1982 • 257 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

Mechanisms of DNA replication and recombination

1984 • 187 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Cloning of the initiation region of a mammalian chromosomal replicon

1983 • 110 citations

Structure of the dihydrofolate reductase gene in Chinese hamster ovary cells

1983 • 87 citations

Organization of a Chinese hamster ovary dihydrofolate reductase gene identified by phenotypic rescue.

1983 • 53 citations

Replication intermediates formed during initiation of DNA synthesis in methotrexate-resistant CHOC 400 cells are enriched for sequences derived from a specific, amplified restriction fragment

1986 • 45 citations

Similar 150-kilobase DNA sequences are amplified in independently derived methotrexate-resistant Chinese hamster cells.

1985 • 37 citations

Mechanism of growth inhibition of H.Ep. 1 cells by 5-fluorodeoxycytidine and 5-fluorodeoxyuridine.

1960 • 28 citations

Multiple initiation sites of DNA replication flanking the origin region of lambda dv genome.

1984 • 22 citations

Organization of a Chinese Hamster Ovary Dihydrofolate Reductase Gene Identified by Phenotypic Rescue

1983 • 19 citations

Aphidicolin arrest irreversibly impairs replicating simian virus 40 chromosomes.

1983 • 19 citations

Similar 150-Kilobase DNA Sequences Are Amplified in Independently Derived Methotrexate-Resistant Chinese Hamster Cells

1985 • 18 citations

In vivo effects of cytosine arabinoside on deoxyribonucleic acid replication in Chinese hamster ovary cells. 2. Cytosine arabinoside affects the rate of synthesis but not the pattern of labeling of an amplified chromosomal sequence at the onset of the S period

1983 • 17 citations

In vivo effects of cytosine arabinoside on deoxyribonucleic acid replication in Chinese hamster ovary cells. 1. Resolution of differential effects on mitochondrial and nuclear deoxyribonucleic acid synthesis

1983 • 16 citations

A densitometer based on a microcomputer and TV camera, for use in the clinical laboratory.

1984 • 12 citations

Isolated HeLa cell nuclei synthesize meaningful DNA

1985 • 4 citations