Only the promoter region of the constitutively expressed normal and amplified human dihydrofolate reductase gene is DNase I hypersensitive and undermethylated.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Genomic sequencing.

1984 • 8,343 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

1981 • 475 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin

1982 • 448 citations

A 200 base pair region at the 5$prime; end of the chicken adult $beta;-globin gene is accessible to nuclease digestion

1981 • 443 citations

DNAase I-hypersensitive sites of chromatin

1981 • 410 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene

1983 • 366 citations

A stretch of “late” SV40 viral DNA about 400 bp long which includes the origin of replication is specifically exposed in SV40 minichromosomes

1979 • 278 citations

A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin

1983 • 273 citations

Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene.

1984 • 249 citations

Structure and genomic organization of the mouse dihydrofolate reductase gene

1980 • 218 citations

Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements

1984 • 217 citations

Methylation and gene control

1982 • 210 citations

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

1983 • 190 citations

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

1982 • 184 citations

Gene expression: DNA methylation — how important in gene control?

1984 • 178 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Unusual methylation pattern of the α2(I) collagen gene

1982 • 177 citations

Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes.

1980 • 172 citations

Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

1976 • 171 citations

Activation of globin genes during chicken development

1981 • 164 citations

Pattern of methylation of two genes coding for housekeeping functions.

1983 • 148 citations

Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus.

1984 • 131 citations

A complex of interacting DNAase I-hypersensitive sites near the drosophila glue protein gene, Sgs4

1982 • 126 citations

Post-transcriptional regulation of the chicken thymidine kinase gene

1984 • 123 citations

DNase I hypersensitive sites in the chromatin of human μ immunoglobulin heavy-chain genes

1983 • 110 citations

tk Enzyme expression in differentiating muscle cells is regulated through an internal segment of the cellular tk gene.

1984 • 98 citations

Human dihydrofolate reductase gene organization

1984 • 93 citations

Structure of a nuclease-sensitive region inside the immunoglobin kappa gene: evidence for a role in gene regulation

1983 • 92 citations

Regulation of dihydrofolate reductase gene expression in mouse fibroblasts during the transition from the resting to growing state

1978 • 89 citations

Cell cycle regulation of dihydrofolate reductase mRNA metabolism in mouse fibroblasts.

1980 • 89 citations

Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts.

1979 • 89 citations

In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated

1983 • 87 citations

Multiple forms of human dihydrofolate reductase messenger RNA

1982 • 84 citations

Control of dihydrofolate reductase messenger ribonucleic acid production.

1981 • 82 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate

1983 • 60 citations

Expression of the J chain gene during B cell differentiation is inversely correlated with DNA methylation.

1981 • 58 citations

A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA

1983 • 55 citations

Is hypomethylation linked to activation of δ-crystallin genes during lens development?

1983 • 53 citations

Control of cellular gene expression during adenovirus infection: induction and shut-off of dihydrofolate reductase gene expression by adenovirus type 2.

1983 • 48 citations

DNase I hypersensitivity in the γ globin gene locus of K562 cells

1983 • 20 citations