DNA Methylation from Embryo to Adult

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

Completion of mouse embryogenesis requires both the maternal and paternal genomes

1984 • 1,529 citations

Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis

1984 • 1,402 citations

Parental imprinting of the mouse H19 gene

1991 • 1,192 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

Primordial germ cells in the mouse embryo during gastrulation

1990 • 995 citations

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

1991 • 904 citations

Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.

1992 • 729 citations

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

1991 • 722 citations

Differential activity of maternally and paternally derived chromosome regions in mice

1985 • 708 citations

THE QUANTITATIVE SEPARATION OF PURINES, PYRIMIDINES, AND NUCLEOSIDES BY PAPER CHROMATOGRAPHY

1948 • 707 citations

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs

1989 • 655 citations

Genomic imprinting: review and relevance to human diseases.

1990 • 621 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

DNA methylation affects the formation of active chromatin

1986 • 588 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Alternative chromatin structure at CpG islands

1990 • 480 citations

Genomic imprinting determines methylation of parental alleles in transgenic mice

1987 • 480 citations

Parental legacy determines methylation and expression of an autosomal transgene: A molecular mechanism for parental imprinting

1987 • 478 citations

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

1992 • 472 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

1990 • 426 citations

Parental-origin-specific epigenetic modification of the mouse H19 gene

1993 • 419 citations

Degree of methylation of transgenes is dependent on gamete of origin

1987 • 407 citations

Parthenogenic Origin of Benign Ovarian Teratomas

1975 • 385 citations

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

1991 • 378 citations

Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation

1993 • 369 citations

The somatic replication of DNA methylation

1981 • 368 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

The ontogeny of allele-specific methylation associated with imprinted genes in the mouse.

1993 • 345 citations

DNA methylation, biochemistry, and biological significance

1984 • 343 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

Methylation levels of maternal and paternal genomes during preimplantation development

1991 • 309 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

DNA Methylation: Molecular Biology and Biological Significance

1993 • 306 citations

Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.

1992 • 279 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

High frequency mutagenesis by a DNA methyltransferase

1992 • 259 citations

Mismatch-specific thymine DNA glycosylase and DNA polymerase beta mediate the correction of G.T mispairs in nuclear extracts from human cells.

1990 • 253 citations

Histone-h1-dependent chromatin superstructures and the suppression of gene activity

1984 • 251 citations

Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis

1991 • 246 citations

Change in the pattern of histone binding to DNA upon transcriptional activation

1989 • 246 citations

Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader–Willi syndrome region

1992 • 243 citations

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

1987 • 241 citations

Effect of regional DNA methylation on gene expression.

1985 • 232 citations

Clonal inheritance of the pattern of DNA methylation in mouse cells.

1982 • 229 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

The transcriptionally-active MMTV promoter is depleted of histone H1

1992 • 222 citations

A DNA methylation imprint, determined by the sex of the parent, distinguishes the angelman and Prader-Willi syndromes

1992 • 212 citations

Specific protection of methylated CpGs in mammalian nuclei

1989 • 195 citations

DNA methylation: Molecular biology and biological significance

1993 • 193 citations

Dominant and specific repression of Xenopus oocyte 5S RNA genes and satellite I DNA by histone H1.

1989 • 188 citations

Variations in DNA methylation during mouse cell differentiation in vivo and in vitro.

1984 • 187 citations

Chromatin structure of transcriptionally competent and repressed genes.

1990 • 178 citations

Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation.

1986 • 175 citations

B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence

1994 • 175 citations

Mitotic stability of fragile X mutations in differentiated cells indicates early post–conceptional trinucleotide repeat expansion

1993 • 174 citations

A quantitative Hpall-PCR assay to measure methylation of DNA from a small number of cells

1990 • 167 citations

Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine.

1993 • 160 citations

Dynamics of demethylation and activation of the α-actin gene in myoblasts

1990 • 159 citations

Demethylation of CpG islands in embryonic cells

1991 • 151 citations

Inviability of parthenogenones is determined by pronuclei, not egg cytoplasm

1984 • 148 citations

Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of promoter methylation on gene expression.

1983 • 139 citations

Mechanistic aspects of genome-wide demethylation in the preimplantation mouse embryo.

1993 • 138 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Biochemistry and biology of DNA methylation

1986 • 134 citations

Methylation patterns of repetitive DNA sequences in germ cells ofMus muscutus

1984 • 126 citations

Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle.

1985 • 111 citations

Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development.

1985 • 107 citations

An estrogen-dependent demethylation at the 5′ end of the chicken vitellogenin gene is independent of DNA synthesis

1984 • 106 citations

5-methylcytosine is localized in nucleosomes that contain histone H1.

1983 • 97 citations

Methylation of CpG sites of two X–linked genes coincides with X–inactivation in the female mouse embryo but not in the germ line

1992 • 90 citations

Inhibition of promoter activity by methylation: possible involvement of protein mediators.

1991 • 88 citations

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

1982 • 85 citations

Induction of alpha-fetoprotein synthesis in differentiating F9 teratocarcinoma cells is accompanied by a genome-wide loss of DNA methylation.

1984 • 85 citations

DNA Methylation in Eukaryotic Cells

1984 • 81 citations

Genetic Studies on Hydatidiform Moles

1984 • 81 citations

Cytosine methylation in CTF and Spl recognition sites of an HSV tk promoter: effects on transcriptionin vivoand on factor bindingin vitro

1989 • 79 citations

A cis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene.

1993 • 78 citations

Methylation of satellite sequences in mouse spermatogenic and somatic DNAs

1984 • 78 citations

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.

1990 • 76 citations

Changes in methylation pattern of albumin and α-fetoprotein genes in developing rat liver and neoplasia

1983 • 70 citations

Effect of in vitro DNA methylation on beta-globin gene expression.

1988 • 69 citations

Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.

1992 • 63 citations

Histone H1-mediated inhibition of transcription initiation of methylated templates in vitro.

1993 • 61 citations

Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.

1991 • 58 citations

Parental methylation patterns of a transgenic locus in adult somatic tissues are imprinted during gametogenesis

1992 • 57 citations

Histone H1 and the conformation of transcriptlonally active chromatin

1991 • 57 citations

Methylation patterns of the human apoA-I/C-III/A-IV gene cluster in adult and embryonic tissues suggest dynamic changes in methylation during development.

1991 • 45 citations

Sequence-specific methylation in a downstream region of the late E2A promoter of adenovirus type 2 DNA prevents protein binding

1989 • 39 citations

Delta-crystallin genes become hypomethylated in postmitotic lens cells during chicken development.

1987 • 35 citations

Relationship between transient DNA hypomethylation and erythroid differentiation of murine erythroleukemia cells.

1988 • 34 citations

Demethylation of genes in animal cells

1990 • 32 citations

Methylation of an α-foetoprotein gene intragenic site modulates gene activity

1992 • 16 citations

Imprinting in leukaemia

1992 • 16 citations