Localization of a bidirectional DNA replication origin in the native locus and in episomally amplified murine adenosine deaminase loci.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Genomic sequencing.

1984 • 8,343 citations

Methods in yeast genetics

1979 • 7,824 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Methods in Yeast Genetics

1988 • 4,905 citations

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

1984 • 2,248 citations

Sequence and gene organization of mouse mitochondrial DNA

1981 • 1,712 citations

High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.

1979 • 1,504 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

The localization of replication origins on ARS plasmids in S. cerevisiae

1987 • 1,051 citations

On the mechanism of DNA replication in mammalian chromosomes

1968 • 950 citations

ANIMAL VIRUS DNA REPLICATION

1989 • 520 citations

The in vivo replication origin of the yeast 2μm plasmid

1987 • 437 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

Identification of an origin of bidirectional DNA replication in mammalian chromosomes

1990 • 288 citations

Replication initiates in a broad zone in the amplified CHO dihydrofolate reductase domain

1990 • 287 citations

Initiation of SV40 DNA replication in vivo: Location and structure of 5′ ends of DNA synthesized in the ori region

1982 • 257 citations

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.

1991 • 248 citations

The importance of circular DNA in mammalian gene amplification.

1989 • 234 citations

Mapping replication units in animal cells

1989 • 232 citations

c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer.

1992 • 212 citations

An amplified chromosomal sequence that includes the gene for dihydrofolate reductase initiates replication within specific restriction fragments.

1982 • 197 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

1992 • 175 citations

Replication of SV40 and Polyoma Virus Chromosomes

1986 • 149 citations

Molecular dissection of mammalian gene amplification: New mechanistic insights revealed by analyses of very early events

1992 • 146 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

1988 • 137 citations

Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines

1991 • 130 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

Autonomous replication of a DNA fragment containing the chromosomal replication origin of the human c-myc gene

1990 • 120 citations

Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

1986 • 116 citations

Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

1989 • 96 citations

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin.

1987 • 80 citations

Selective overproduction of adenosine deaminase in cultured mouse cells.

1983 • 75 citations

Double minutes replicate once during S phase of the cell cycle

1980 • 65 citations

The distribution and properties of RNA primed initiation sites of DNA synthesis at the replication origin ofEscherichia colichromosome

1985 • 62 citations

Early appearance and long-term persistence of the submicroscopic extrachromosomal elements (amplisomes) containing the amplified DHFR genes in human cell lines.

1990 • 58 citations

Prognostic factors in human primary breast cancer: Comparison of c-myc and HER2/neu amplification

1992 • 54 citations

Molecular Dissection of an Extrachromosomal Amplicon Reveals a Circular Structure Consisting of an Imperfect Inverted Duplication

1993 • 42 citations

Amplification and Loss of Dihydrofolate Reductase Genes in a Chinese Hamster Ovary Cell Line

1981 • 42 citations

Nuclear DNA synthesis in vitro is mediated via stable replication forks assembled in a temporally specific fashion in vivo.

1988 • 40 citations

Ultrastructure of double minutes from a human tumor cell line.

1979 • 39 citations

Replication forks are underrepresented in chromosomal DNA of Xenopus laevis embryos.

1986 • 36 citations

Relationship of Amplified Dihydrofolate Reductase Genes to Double Minute Chromosomes in Unstably Resistant Mouse Fibroblast Cell Lines

1981 • 34 citations

Introduction of YACs containing a putative mammalian replication origin into mammalian cells can generate structures that replicate autonomously

1993 • 32 citations

An electron microscope study of chromosomal DNA replication in different eukaryotic systems

1982 • 32 citations

Model for the formation of double minutes from prematurely condensed chromosomes of replicating micronuclei in drug-treated Chinese hamster ovary cells undergoing DNA amplification.

1989 • 29 citations

Animal Virus DNA Replication

1989 • 27 citations

Structure of amplified DNA, analyzed by pulsed field gradient gel electrophoresis

1987 • 26 citations

Replication Timing Control Can Be Maintained in Extrachromosomally Amplified Genes

1991 • 26 citations

Start sites for bidirectional in vitro DNA replication inside the replication origin, oriC, of Escherichia coli.

1987 • 22 citations

Replication of Simian Virus 40 and Polyoma Virus Chromosomes

1987 • 19 citations

Cloned Mouse DNA Fragments Can Replicate in a Simian Virus 40 T Antigen-Dependent System In Vivo and In Vitro

1985 • 14 citations

Activation of a mammalian origin of replication by chromosomal rearrangement.

1992 • 13 citations

Nuclear DNA Synthesis In Vitro is Mediated via Stable Replication Forks Assembled in a Temporally Specific Fashion In Vivo

1988 • 12 citations

Replication timing control can be maintained in extrachromosomally amplified genes.

1991 • 12 citations

Induced sister chromatid exchange frequency is not increased in homogeneously staining regions that contain amplified genes

1987 • 8 citations

Replication of the dihydrofolate reductase genes on double minute chromosomes in a murine cell line

1990 • 7 citations

Cloned mouse DNA fragments can replicate in a simian virus 40 T antigen-dependent system in vivo and in vitro.

1985 • 7 citations

Activation of a Mammalian Origin of Replication by Chromosomal Rearrangement

1992 • 6 citations

Deleted Work

1955 • 0 citations