Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

2007 • 4,449 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

The Calpain System

2003 • 2,708 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

CREB AND MEMORY

1998 • 1,421 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Intraneuronal Aβ42 Accumulation in Human Brain

2000 • 955 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

Calpain and caspase: can you tell the difference?

2000 • 911 citations

Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

2001 • 581 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.

2001 • 516 citations

Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

2002 • 508 citations

The calpain family and human disease

2001 • 465 citations

β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:In VitroandIn VivoMechanisms Related to Alzheimer's Disease

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Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

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Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons

1992 • 421 citations

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

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Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory

2006 • 397 citations

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

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Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons

1996 • 353 citations

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

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Activity-dependent long-term enhancement of transmitter release by presynaptic 3′,5′-cyclic GMP in cultured hippocampal neurons

1995 • 306 citations

Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.

1984 • 294 citations

Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.

1995 • 243 citations

β-Amyloid-induced Dynamin 1 Degradation Is Mediated by N-Methyl-D-Aspartate Receptors in Hippocampal Neurons

2006 • 241 citations

Amyloid-β Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-Responsive Element-Binding Protein Pathway during Hippocampal Synaptic Plasticity

2005 • 231 citations

Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

1988 • 218 citations

Accelerated Plaque Accumulation, Associative Learning Deficits, and Up-regulation of α7 Nicotinic Receptor Protein in Transgenic Mice Co-expressing Mutant Human Presenilin 1 and Amyloid Precursor Proteins

2002 • 214 citations

The calpains in aging and aging-related diseases

2003 • 204 citations

Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation

1998 • 199 citations

Calpain and caspase: can you tell the difference?, by Kevin K.W. Wang

2000 • 190 citations

Degradation of Microtubule‐Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study

1991 • 180 citations

α-Synuclein produces a long-lasting increase in neurotransmitter release

2004 • 180 citations

Mechanisms of synaptic dysfunction in Alzheimer's disease.

1995 • 170 citations

Rapid Increase in Clusters of Presynaptic Proteins at Onset of Long-Lasting Potentiation

2001 • 168 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

1997 • 164 citations

Distinct Mechanistic Roles of Calpain and Caspase Activation in Neurodegeneration as Revealed in Mice Overexpressing Their Specific Inhibitors

2005 • 155 citations

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

1997 • 150 citations

Capsaicin-induced neurotoxicity in cultured dorsal root ganglion neurons: Involvement of calcium-activated proteases

1995 • 146 citations

Niemann-Pick Type C Disease and Alzheimer's Disease

2004 • 130 citations

Calpain Mediates Calcium-Induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons

2004 • 124 citations

Presynaptic CaMKII Is Necessary for Synaptic Plasticity in Cultured Hippocampal Neurons

2004 • 120 citations

The ultrastructural localization of calcium‐activated protease “calpain” in rat brain

1988 • 112 citations

Proteolytic processing of beta-amyloid precursor by calpain I

1990 • 105 citations

Proteolytic Degradation of SCOP in the Hippocampus Contributes to Activation of MAP Kinase and Memory

2007 • 105 citations

Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein

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Inhibitions by E-64 Derivatives of Rat Liver Cathepsin B and Cathepsin L In Vitro and In Vivo 1

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Calpain : pharmacology and toxicology of calcium-dependent protease

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Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12

2002 • 93 citations

Development and Therapeutic Potential of Calpain Inhibitors

1996 • 91 citations

m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains

1998 • 89 citations

ELISA Method for Measurement of Amyloid-β Levels

2005 • 74 citations

Calpain inhibitors

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Calpain Inhibitor I Increases β-Amyloid Peptide Production by Inhibiting the Degradation of the Substrate of γ-Secretase

1999 • 70 citations

Differential sensitivity of FOS and JUN family members to calpains.

1994 • 69 citations

Endogenous Cleavage of Phospholipase C-β3 by Agonist-induced Activation of Calpain in Human Platelets

1995 • 64 citations

Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate.

1987 • 63 citations

Amyloid Precursor Protein Family-induced Neuronal Death Is Mediated by Impairment of the Neuroprotective Calcium/Calmodulin Protein Kinase IV-dependent Signaling Pathway

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Tissue Processing Prior to Protein Analysis and Amyloid-β Quantitation

2005 • 44 citations

Possible Role of Calpain in Normal Processing of β-Amyloid Precursor Protein in Human Platelets

2000 • 34 citations

The Phosphorylation State of GluR1 Subunits Determines the Susceptibility of AMPA Receptors to Calpain Cleavage

2007 • 28 citations

Truncations of amphiphysin I by calpain inhibit vesicle endocytosis during neural hyperexcitation

2007 • 27 citations

BDA-410: A novel synthetic calpain inhibitor active against blood stage malaria

2007 • 26 citations

Cell Cultures From Animal Models of Alzheimer's Disease as a Tool for Faster Screening and Testing of Drug Efficacy

2004 • 21 citations

Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease.

2003 • 17 citations