BDA-410: A novel synthetic calpain inhibitor active against blood stage malaria

Human Malaria Parasites in Continuous Culture

1976 • 7,687 citations

Four plasmepsins are active in thePlasmodium falciparumfood vacuole, including a protease with an active-site histidine

2002 • 435 citations

Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

2006 • 331 citations

Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

2000 • 326 citations

Cysteine proteases of malaria parasites

2004 • 311 citations

Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

1991 • 311 citations

A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite

2002 • 284 citations

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

2004 • 273 citations

Disruption of the Mouse μ-Calpain Gene Reveals an Essential Role in Platelet Function

2001 • 237 citations

Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins

2002 • 235 citations

Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis

2000 • 224 citations

Cell-penetrating inhibitors of calpain

1991 • 224 citations

Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors

1996 • 183 citations

Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.

1991 • 173 citations

Selective Inhibition of a Two-step Egress of Malaria Parasites from the Host Erythrocyte

2003 • 161 citations

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones

2002 • 155 citations

Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.

1993 • 154 citations

Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum

2006 • 148 citations

Double‐stranded RNA‐mediated gene silencing of cysteine proteases (falcipain‐1 and ‐2) of Plasmodium falciparum

2002 • 123 citations

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites

2004 • 120 citations

Structural and Functional Characterization of Falcipain-2, a Hemoglobinase from the Malarial Parasite Plasmodium falciparum

2006 • 115 citations

Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development

2002 • 115 citations

Hydrolysis of erythrocyte proteins by proteases of malaria parasites

2002 • 112 citations

Plasmodium falciparum: Protease inhibitors and inhibition of erythrocyte invasion

1986 • 95 citations

Plasmodium falciparum antigens synthesized by schizonts and stabilized at the merozoite surface when schizonts mature in the presence of protease inhibitors.

1986 • 91 citations

Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development

1989 • 88 citations

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

2004 • 88 citations

Antimalarial Activities of Novel SyntheticCysteine ProteaseInhibitors

2003 • 74 citations

Novel Peptidomimetic Cysteine Protease Inhibitors as Potential Antimalarial Agents

2006 • 66 citations

Calpain Inhibitors, a Treatment for Alzheimer's Disease: Position Paper

2003 • 66 citations

Ankyrin Peptide Blocks Falcipain-2-mediated Malaria Parasite Release from Red Blood Cells

2003 • 62 citations

A cysteine protease activity from Plasmodium falciparum cleaves human erythrocyte ankyrin

2000 • 44 citations

Characterization of events preceding the release of malaria parasite from the host red blood cell

2005 • 38 citations

Effect of calpain inhibitors on the invasion of human erythrocytes by the parasite Plasmodium flaciparum

1991 • 33 citations

Neutral proteases involved in the reinvasion of erythrocytes by Plasmodium merozoites

1988 • 21 citations

Erythrocyte calpain is dispensable for malaria parasite invasion and growth

2002 • 14 citations

Cloning and characterization of Plasmodium falciparum cysteine protease, falcipain-2B

2006 • 12 citations