Calpain Mediates Calcium-Induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Life and Death of Neurons in the Aging Brain

1997 • 1,323 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway.

2000 • 517 citations

Neuronal and glial calcium signaling in Alzheimer’s disease

2003 • 443 citations

BDNF Protects the Neonatal Brain from Hypoxic-Ischemic InjuryIn Vivovia the ERK Pathway

2000 • 432 citations

Identification of the major multiphosphorylation site in mammalian neurofilaments.

1988 • 394 citations

Cutting to the chase: calpain proteases in cell motility

2002 • 386 citations

Monoclonal antibody to neurofilament protein (SMI‐32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex

1989 • 366 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

A Ca2+ Switch Aligns the Active Site of Calpain

2002 • 322 citations

Neurofilament phosphorylation: a new look at regulation and function

1991 • 309 citations

Discussion

1997 • 279 citations

The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.

1987 • 278 citations

Activation of Calpain I Converts Excitotoxic Neuron Death into a Caspase-independent Cell Death

2000 • 264 citations

Calcium‐Activated Neutral Proteinase (Calpain) System in Aging and Alzheimer's Disease^a

1994 • 254 citations

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer’s disease

2002 • 234 citations

Dephosphorylation of neurofilament proteins enhances their susceptibility to degradation by calpain

1988 • 232 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

1998 • 231 citations

Chapter 37 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease

2002 • 229 citations

Calcium and neuronal ageing

1998 • 228 citations

Phosphorylated Map Kinase (ERK1, ERK2) Expression is Associated with Early Tau Deposition in Neurones and Glial Cells, but not with Increased Nuclear DNA Vulnerability and Cell Death, in Alzheimer Disease, Pick's Disease, Progressive Supranuclear Palsy and Corticobasal Degeneration

2001 • 228 citations

Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity

1998 • 227 citations

Neurofilament functions in health and disease

1999 • 212 citations

Ionomycin-activated Calpain Triggers Apoptosis

2002 • 207 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies

1986 • 206 citations

The calpains in aging and aging-related diseases

2003 • 204 citations

Neurotrophic Factors in Central Nervous System Trauma

1995 • 204 citations

Developmental Changes in τ Phosphorylation: Fetal τ Is Transiently Phosphorylated in a Manner Similar to Paired Helical Filament‐τ Characteristic of Alzheimer's Disease

1993 • 184 citations

Neurofilaments and neurological disease

2003 • 180 citations

Regional Selective Neuronal Degeneration after Protein Phosphatase Inhibition in Hippocampal Slice Cultures: Evidence for a MAP Kinase-Dependent Mechanism

1998 • 170 citations

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

1990 • 168 citations

The Regulation of Neurofilament Protein Dynamics by Phosphorylation: Clues to Neurofibrillary Pathobiology

1993 • 164 citations

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease

1987 • 161 citations

Regulation of microtubule composition and stability during nerve growth factor-promoted neurite outgrowth.

1986 • 154 citations

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

1997 • 150 citations

PD98059 Prevents Neurite Degeneration Induced by Fibrillar β‐Amyloid in Mature Hippocampal Neurons

2000 • 141 citations

Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease

1994 • 133 citations

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid‐treated SY5Y cells

2001 • 131 citations

Induction of an Immediate Early Gene egr‐1 by Zinc Through Extracellular Signal‐Regulated Kinase Activation in Cortical Culture

1999 • 127 citations

Copper/Zinc Superoxide Dismutase Attenuates Neuronal Cell Death by Preventing Extracellular Signal-Regulated Kinase Activation after Transient Focal Cerebral Ischemia in Mice

2002 • 126 citations

Protein kinases and phosphorylation in neurologic disorders and cell death.

1991 • 108 citations

Calpains: Intact and active?

1997 • 99 citations

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2

2002 • 97 citations

Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells

2001 • 96 citations

The Mimetic Orchestra

1996 • 91 citations

Neuronal Cyclin‐Dependent Kinase‐5 Phosphorylation Sites in Neurofilament Protein (NF‐H) Are Dephosphorylated by Protein Phosphatase 2A

1995 • 88 citations

Diphosphorylation and involvement of extracellular signal-regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons

2000 • 87 citations

Sequence variants in human neurofilament proteins: Absence of linkage to familial amyotrophic lateral sclerosis

1996 • 86 citations

Sodium dodecyl sulfate-gel electrophoresis: Staining of polypeptides using heavy metal salts

1988 • 76 citations

Activation of ERK1/2 after neonatal rat cerebral hypoxia–ischaemia

2003 • 74 citations

A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degeneration

2002 • 62 citations

Neurotrophin‐3 enhances neurite outgrowth in cultured hippocampal pyramidal neurons

1994 • 60 citations

p^44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons

1993 • 58 citations

Role of cdk5 in the Pathogenesis of Alzheimer’s Disease

2003 • 57 citations

Cyclin-Dependent Kinase 5 in Neurofilament Function and Regulation

2003 • 54 citations

Phosphorylation loops in synthetic peptides of the human neurofilament protein middle-sized subunit

1988 • 47 citations

Collaboration of JNKs and ERKs in Nerve Growth Factor Regulation of the Neurofilament Light Chain Promoter in PC12 Cells

2002 • 47 citations

Dysfunctional intracellular calcium homoeostasis: a central cause of neurodegeneration in Alzheimer's disease

2001 • 46 citations

Amyloid β neurotoxicity not mediated by the mitogen-activated protein kinase cascade in cultured rat hippocampal and cortical neurons

2000 • 43 citations

Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons

1996 • 43 citations

Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses

1997 • 42 citations

Crucial role of calpain in hypoxic PC12 cell death: Calpain, but not caspases, mediates degradation of cytoskeletal proteins and protein kinase C-α and-δ

2001 • 36 citations

Regulation of axonal neurofilament phosphorylation

2001 • 34 citations

Calpain regulation of integrin α_IIbβ₃signaling in human platelets

2000 • 33 citations

Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by munc-18

1996 • 30 citations

Object identification deficits in dementia of the Alzheimer type: Combined effects of semantic and visual proximity

1999 • 27 citations

Free PKC catalytic subunits (PKM) phosphorylate tau via a pathway distinct from that utilized by intact PKC

1999 • 25 citations

P301L tauopathy

2002 • 23 citations

Early diagnosis and the clinical genetics of Alzheimer's disease

1999 • 20 citations

HincII RFLP in the human gene for the heavy neurofilament subunit (NF-H)

1989 • 3 citations