The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 • 3,545 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

2003 • 1,828 citations

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

2007 • 1,809 citations

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

2007 • 1,808 citations

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

2007 • 1,772 citations

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

2008 • 1,524 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

2007 • 1,446 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

2008 • 1,250 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses

2007 • 968 citations

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

2006 • 947 citations

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

2003 • 917 citations

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

2006 • 898 citations

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

2008 • 897 citations

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

2007 • 870 citations

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

2006 • 831 citations

Differentiation and function of Th17 T cells

2007 • 720 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner

2007 • 622 citations

Expanding the effector CD4 T-cell repertoire: the Th17 lineage

2006 • 595 citations

Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation

2004 • 592 citations

Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells

2007 • 540 citations

CXCL13 Is Required for B1 Cell Homing, Natural Antibody Production, and Body Cavity Immunity

2002 • 521 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

2007 • 447 citations

Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

2008 • 349 citations

Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

2000 • 308 citations

IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease

2007 • 266 citations

IL-6–gp130–STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state

2007 • 245 citations

Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells

2008 • 218 citations

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

2001 • 218 citations

Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans

1999 • 207 citations

Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells

2004 • 194 citations

Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype

2007 • 133 citations

FoxP3+ T Cells Undergo Conventional First Switch to Lymphoid Tissue Homing Receptors in Thymus but Accelerated Second Switch to Nonlymphoid Tissue Homing Receptors in Secondary Lymphoid Tissues

2007 • 123 citations

IL-17A augments TNF-α–induced IL-6 expression in airway smooth muscle by enhancing mRNA stability

2004 • 101 citations

CC Chemokine Receptor 6 Expression by B Lymphocytes Is Essential for the Development of Isolated Lymphoid Follicles

2007 • 91 citations

Interleukin-21: A new modulator of immunity, infection, and cancer

2007 • 80 citations

Induction of granulocyte-macrophage colony-stimulating factor by a new cytokine, ML-1 (IL-17F), via Raf I-MEK-ERK pathway

2004 • 76 citations

Identification of a Chemokine Network That Recruits FoxP3+ Regulatory T Cells Into Chronically Inflamed Intestine

2007 • 60 citations

RORγt Recruits Steroid Receptor Coactivators to Ensure Thymocyte Survival

2005 • 56 citations