Hematopoietic stem cell expansion

Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease

1995 • 607 citations

Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults.

1992 • 506 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

Reconstitution of Hematopoiesis after High-Dose Chemotherapy by Autologous Progenitor Cells Generated ex Vivo

1995 • 382 citations

Review: Stratton Lecture 1990. Clinical implications of positive and negative hematopoietic stem cell regulators

1991 • 369 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function

1995 • 340 citations

Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin

1993 • 334 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 291 citations

Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors

1995 • 285 citations

Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures

1993 • 280 citations

Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics

1996 • 224 citations

Selection and expansion of peripheral blood CD34+ cells in autologous stem cell transplantation for breast cancer

1996 • 184 citations

Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood

1994 • 178 citations

Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow.

1990 • 171 citations

Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential

1993 • 166 citations

Continuous human bone marrow culture: Ia antigen characterization of probable pluripotential stem cells

1980 • 160 citations

Evaluation of ex vivo expansion potential of cord blood and bone marrow hematopoietic progenitor cells using cell tracking and limiting dilution analysis

1995 • 148 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 141 citations

Maintenance of transplantation potential in ex vivo expanded CD34(+)- selected human peripheral blood progenitor cells

1994 • 139 citations

Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

1994 • 139 citations

Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells

1996 • 137 citations

Human CD34+ HLA-DR- bone marrow cells contain progenitor cells capable of self-renewal, multilineage differentiation, and long-term in vitro hematopoiesis.

1991 • 132 citations

Evaluation of the in vitro behavior of phenotypically defined populations of umbilical cord blood hematopoietic progenitor cells.

1994 • 129 citations

Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture

1991 • 117 citations

Ex vivo expansion of murine hematopoietic progenitor cells generates classes of expanded cells possessing different levels of bone marrow repopulating potential.

1996 • 112 citations

Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells.

1992 • 104 citations

Hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood progenitor cells evaluated in vitro and in vivo

1996 • 104 citations

Cell cycle and functional differences between CD34+/CD38hi and CD34+/38lo human marrow cells after in vitro cytokine exposure

1995 • 100 citations

Stromal support enhances cell-free retroviral vector transduction of human bone marrow long-term culture-initiating cells

1992 • 93 citations

Rapid exit from G0/G1 phases of cell cycle in response to stem cell factor confers on umbilical cord blood CD34+ cells an enhanced ex vivo expansion potential.

1994 • 87 citations

Net increase of pluripotential hematopoietic precursors in suspension culture in response to IL-1 and IL-3.

1989 • 83 citations

Retention of quiescent hematopoietic cells with high proliferative potential during ex vivo stem cell culture

1996 • 81 citations

Maintenance of murine long-term repopulating stem cells in ex vivo culture is affected by modulation of transforming growth factor-beta but not macrophage inflammatory protein-1 alpha activities

1996 • 76 citations

Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells

1993 • 74 citations

Purification and partial characterization of a human hematopoietic precursor population

1991 • 69 citations

Expansion of neutrophil precursors and progenitors in suspension cultures of CD34+ cells enriched from human bone marrow.

1993 • 63 citations

Large Volume Ex Vivo Expansion of CD34-Positive Hematopoietic Progenitor Cells for Transplantation

1995 • 63 citations

Questions to be answered regarding umbilical cord blood hematopoietic stem and progenitor cells and their use in‐transplantation

1995 • 59 citations

Long-term reconstitution of mice after ex vivo expansion of bone marrow cells: differential activity of cultured bone marrow and enriched stem cell populations.

1994 • 58 citations

Myofibroblastic stromal cells isolated from human bone marrow induce the proliferation of both early myeloid and B-lymphoid cells

1993 • 48 citations

Expansion of myeloid stem cells in culture.

1995 • 37 citations

Endothelial cell support of hematopoiesis is differentially altered by IL-1 and glucocorticoids

1998 • 37 citations

The presence of an autologous marrow stromal cell layer increases glucocerebrosidase gene transduction of long-term culture initiating cells (LTCICs) from the bone marrow of a patient with Gaucher disease.

1995 • 34 citations

Long-term Hematopoietic Culture-initiating Cells Are More Abundant in Mobilized Peripheral Blood Grafts Than in Bone Marrow but Have a More Limited Ex Vivo Expansion Potential

1996 • 28 citations

Synergistic effects of interleukin-1 beta and interleukin-3 on the expansion of human hematopoietic progenitor cells in liquid cultures

1991 • 27 citations

Ex vivo expansion of peripheral blood progenitor cells with recombinant cytokines.

1992 • 26 citations

Culture of Purified Stem Cells from Fetal Liver Results in Loss of In Vivo Repopulating Potential

1996 • 25 citations

Expansion of Blood CD34+ Cells: Committed Precursor Expansion Does Not Affect Immature Hematopoietic Progenitors

1997 • 25 citations

Use of hematopoietic growth factors for in vitro expansion of precursor cell populations

1995 • 22 citations

Cytokine-mediated expansion of 5-FU-resistant peripheral blood stem cells.

1995 • 22 citations

Retroviral-mediated gene transfer in human bone marrow cells growth in continuous perfusion culture vessels.

1995 • 20 citations

Effects of recombinant human Steel factor (c-kit ligand) on early cord blood hematopoietic precursors.

1994 • 20 citations

The effect of cytokines on CD34+ Rh-123high and low progenitor cells from human umbilical cord blood.

1994 • 19 citations

Combination of recombinant cytokines fails to produce ex vivo expansion of human blood hematopoietic progenitor cells

1992 • 10 citations

Very high concentrations of cytokines are required for the maximal stimulation in vitro of primitive human hematopoietic progenitors and are depleted most rapidly by subpopulations of cells that are highly enriched in their LTC-IC content

1995 • 4 citations

Comparative analysis of the influences of IL-1, IL-3 and GM-CSF on the commitment of granulocyte-macrophage progenitors in vitro

1991 • 3 citations