PML Is a Direct p53 Target that Modulates p53 Effector Functions

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Surfing the p53 network

2000 • 6,487 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Atmospheric carbon dioxide concentrations over the past 60 million years

2000 • 1,734 citations

Control of apoptosis by p53

2003 • 1,343 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

Decision making by p53: life, death and cancer

2003 • 1,055 citations

Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia

1999 • 1,042 citations

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1998 • 912 citations

Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

2003 • 835 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Senescence of human fibroblasts induced by oncogenic Raf

1998 • 805 citations

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

2002 • 803 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

1994 • 743 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Signaling to p53

1998 • 636 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

The transcriptional role of PML and the nuclear body

2000 • 574 citations

Pml is essential for multiple apoptotic pathways

1998 • 564 citations

The Role of PML in Tumor Suppression

2002 • 552 citations

Role of PML in Cell Growth and the Retinoic Acid Pathway

1998 • 522 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Cancer and ageing: rival demons?

2003 • 498 citations

The function of PML in p53-dependent apoptosis

2000 • 464 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

Arsenic-induced PML targeting onto nuclear bodies: Implications for the treatment of acute promyelocytic leukemia

1997 • 430 citations

PML induces a novel caspase-independent death process

1998 • 384 citations

Regulation of p53 activity in nuclear bodies by a specific PML isoform

2000 • 371 citations

bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

1997 • 371 citations

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

2003 • 353 citations

Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene.

1993 • 332 citations

Pondering the Promyelocytic Leukemia Protein (PML) Puzzle: Possible Functions for PML Nuclear Bodies

2002 • 308 citations

The p53MH algorithm and its application in detecting p53-responsive genes

2002 • 292 citations

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

2002 • 280 citations

Role and fate of PML nuclear bodies in response to interferon and viral infections

2001 • 278 citations

Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.

1995 • 268 citations

DNA viruses and viral proteins that interact with PML nuclear bodies

2001 • 245 citations

Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

1996 • 244 citations

PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

2002 • 234 citations

Deconstructing PML-induced premature senescence

2002 • 222 citations

Induction of the PML protein by interferons in normal and APL cells.

1995 • 216 citations

Role of Promyelocytic Leukemia (Pml) Protein in Tumor Suppression

2001 • 158 citations

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

1995 • 137 citations

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

2002 • 131 citations

The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation

2003 • 129 citations

PML interaction with p53 and its role in apoptosis and replicative senescence

2001 • 123 citations

The theory of APL

2001 • 106 citations

Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization

2003 • 88 citations

Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia

2003 • 71 citations

Physical and Functional Interactions between PML and MDM2

2003 • 68 citations

UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML

2003 • 53 citations

Cancer and ageing

2004 • 7 citations