The Physiology Of Transforming Growth Factor-α

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth Factor

1984 • 666 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues

1985 • 568 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

The Primary Structure of Epidermal Growth Factor

1972 • 533 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells.

1983 • 484 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Expression of Transforming Growth Factor α and its Messenger Ribonucleic Acid in Human Breast Cancer: Its Regulation by Estrogen and its Possible Functional Significance

1988 • 440 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Cloning and sequence analysis of a cDNA for rat transforming growth factor-α

1985 • 388 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor

1984 • 377 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Induction of transforming growth factor-α in activated human alveolar macrophages

1988 • 359 citations

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.

1988 • 354 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor

1987 • 297 citations

Developmental expression of transforming growth factors alpha and beta in mouse fetus.

1988 • 272 citations

Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells

1988 • 267 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

Molecular characterization of a gene of the ‘EGF family’ expressed in undifferentiated human NTERA2 teratocarcinoma cells.

1989 • 251 citations

Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.

1991 • 247 citations

Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype.

1989 • 246 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal.

1989 • 243 citations

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

1990 • 241 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Epidermal Growth Factor

1973 • 233 citations

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

1987 • 230 citations

Human transforming growth factor. Production by a melanoma cell line, purification, and initial characterization.

1982 • 223 citations

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.

1991 • 209 citations

Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.

1987 • 202 citations

A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

1990 • 198 citations

The many faces of epidermal growth factor repeats.

1990 • 197 citations

Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain

1988 • 189 citations

Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor

1985 • 185 citations

Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.

1986 • 180 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

Human transforming growth factor-alpha stimulates bone resorption in vitro.

1985 • 169 citations

Expression of Rat Transforming Growth Factor Alpha mRNA during Development Occurs Predominantly in the Maternal Decidua

1987 • 162 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Structure, expression and function of a schwannoma-derived growth factor

1990 • 153 citations

Tumor products and the hypercalcemia of malignancy.

1985 • 151 citations

Local effects of EGF, α‐TGF, and EGF‐like growth factors on lobuloalveolar development of the mouse mammary gland in vivo

1987 • 147 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

Peptide Growth Factors and Their Receptors II

1990 • 142 citations

Transforming Growth Factor α Production and Epidermal Growth Factor Receptor Expression in Normal and Oncogene Transformed Human Mammary Epithelial Cells

1989 • 135 citations

Complete Nucleotide Sequences of Two Adjacent Early Vaccinia Virus Genes Located Within the Inverted Terminal Repetition

1982 • 133 citations

Induction of Transforming Growth Factor-α Expression in Human Keratinocytes by Phorbol Esters

1989 • 131 citations

Expression of Transforming Growth Factor α (TGFα) in Differentiated Rat Mammary Tumors: Estrogen Induction of TGFα Production

1987 • 124 citations

Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

1986 • 121 citations

Expression of rat transforming growth factor alpha mRNA during development occurs predominantly in the maternal decidua.

1987 • 121 citations

The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

1987 • 115 citations

Recombinant Human Epidermal Growth Factor Precursor Is a Glycosylated Membrane Protein with Biological Activity

1989 • 111 citations

Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-α

1987 • 110 citations

Phorbol Ester or Epidermal Growth Factor (EGF) Stimulates the Concurrent Accumulation of mRNA for the EGF Receptor and Its Ligand Transforming Growth Factor-α in a Breast Cancer Cell Line

1989 • 110 citations

Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

1987 • 108 citations

Characterization of high molecular weight transforming growth factor .alpha. produced by rat hepatocellular carcinoma cells

1988 • 107 citations

Differential Processing of Colony-Stimulating Factor 1 Precursors Encoded by Two Human cDNAs

1988 • 103 citations

Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha

1987 • 102 citations

Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor alpha cDNA

1989 • 102 citations

Human transforming growth factor-α causes precocious eyelid opening in newborn mice

1985 • 101 citations

Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.

1987 • 100 citations

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene.

1987 • 100 citations

Astrocyte Mitogen Inhibitor Related to Epidermal Growth Factor Receptor

1988 • 95 citations

Expression of transfected transforming growth factor alpha induces a motile fibroblast-like phenotype with extracellular matrix-degrading potential in a rat bladder carcinoma cell line.

1990 • 95 citations

Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody.

1986 • 86 citations

Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha.

1987 • 82 citations

Epidermal growth factor: Is the precursor a receptor?

1985 • 81 citations

The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.

1987 • 73 citations

Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.

1988 • 71 citations

TGFα stimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression

1988 • 70 citations

Structural properties of a soluble bioactive precursor for transforming growth factor-alpha.

1988 • 65 citations

Polyoma virus-transformed cells produce transforming growth factor(s) and grow in serum-free medium

1982 • 64 citations

Transforming Growth Factor-α Stimulates Proto-Oncogene c-junExpression and a Mitogenic Program in Primary Cultures of Adult Rat Hepatocytes

1989 • 63 citations

Recombinant human epidermal growth factor precursor is a glycosylated membrane protein with biological activity.

1989 • 63 citations

Generation of transforming growth factor-alpha from the cell surface by an O-glycosylation-independent multistep process.

1990 • 61 citations

Transforming Growth Factor-α Expression in the Anterior Pituitary Gland: Regulation by Epidermal Growth Factor and Phorbol Ester in Dispersed Cells

1989 • 56 citations

Simian virus 40 induces the production of a polypeptide transforming factor(s)

1981 • 54 citations

Induction of Transforming Growth Factor α Expression in Mouse Mammary Epithelial Cells after Transformation with a Point-Mutated c-Ha-rasProtooncogene

1988 • 51 citations

Synthesis of a biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus

1988 • 41 citations

Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.

1986 • 37 citations

Growth regulation of A431 cells. Modulation of expression of transforming growth factor-alpha mRNA and 2',5'-oligoadenylate synthetase activity.

1990 • 25 citations

Differential growth factor expression in transformed mouse NIH‐3T3 cells

1990 • 25 citations