Neuroendocrine Mechanisms in Pregnancy and Parturition

Epidemiology and causes of preterm birth

2008 • 7,083 citations

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Knobil and Neill's Physiology of Reproduction

2015 • 1,225 citations

On some physiological actions of ergot

1906 • 980 citations

Expression cloning of a human corticotropin-releasing-factor receptor.

1993 • 923 citations

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

2001 • 911 citations

A placental clock controlling the length of human pregnancy

1995 • 897 citations

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

2001 • 877 citations

Endocrine and Paracrine Regulation of Birth at Term and Preterm*

2000 • 842 citations

Synthesis, Transport, and Release of Posterior Pituitary Hormones

1980 • 814 citations

Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.

1996 • 712 citations

Neuroendocrinology of the Skin1

2000 • 678 citations

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

2001 • 647 citations

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

1997 • 599 citations

Fetal umbilical artery flow velocity waveforms and placental resistance: clinical significance

1985 • 565 citations

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

1996 • 561 citations

Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need

1995 • 525 citations

Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo

1991 • 485 citations

Neuroendocrinology of the Skin

2000 • 470 citations

Actions of Placental and Fetal Adrenal Steroid Hormones in Primate Pregnancy*

1995 • 469 citations

Inhibition of oxytocin receptor function by direct binding of progesterone

1998 • 468 citations

Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks’ gestation in pregnancies ending in preterm delivery

1999 • 465 citations

CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.

1995 • 444 citations

Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta.

1988 • 437 citations

Isolation and sequence analysis of the human corticotropin-releasing factor precursor gene.

1983 • 420 citations

Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor.

1993 • 414 citations

Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta

1998 • 399 citations

Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): Priming the placental clock

2005 • 393 citations

Plasma Corticotropin-Releasing Hormone Concentrations During Pregnancy and Parturition*

1987 • 388 citations

Parturition

2007 • 387 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

Uterine Receptivity for Nidationa

1986 • 371 citations

Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins

1991 • 358 citations

Urocortin Expression in Rat Brain: Evidence Against a Pervasive Relationship of Urocortin-Containing Projections With Targets Bearing Type 2 CRF Receptors

1999 • 354 citations

The Molecular Mechanisms Underlying the Regulation of the Biological Activity of Corticotropin-Releasing Hormone Receptors: Implications for Physiology and Pathophysiology

2006 • 345 citations

Neurophysiology and neuropharmacology of hypothalamic magnocellular neurons secreting vasopressin and oxytocin

1991 • 343 citations

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

1985 • 335 citations

Evidence for local stimulation of ACTH secretion by corticotropin-releasing factor in human placenta

1987 • 334 citations

Peptide Signaling in Human Placenta and Membranes: Autocrine, Paracrine, and Endocrine Mechanisms*

1996 • 334 citations

Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors

1993 • 320 citations

The fetal placental hypothalamic–pituitary–adrenal (HPA) axis, parturition and post natal health

2001 • 299 citations

Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses.

1993 • 297 citations

Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family

1993 • 291 citations

Evolution and Physiology of the Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Vertebrates

1999 • 282 citations

The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy

2003 • 280 citations

High Levels of Corticotropin-Releasing Hormone Immunoactivity in Maternal and Fetal Plasma during Pregnancy*

1986 • 280 citations

Characterization and gestational regulation of corticotropin-releasing hormone messenger RNA in human placenta.

1988 • 267 citations

Molecular Identification and Analysis of a Novel Human Corticotropin-Releasing Factor (CRF) Receptor: The CRF2γ Receptor

1998 • 258 citations

Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition.

1993 • 255 citations

First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis

2003 • 245 citations

Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH

1999 • 242 citations

Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides

1995 • 239 citations

Opposing actions of prostaglandins and oxytocin determine the onset of murine labor

1998 • 238 citations

Expression and regulation of the pattern recognition receptors Toll‐like receptor‐2 and Toll‐like receptor‐4 in the human placenta

2002 • 238 citations

Structural organization of the human oxytocin receptor gene.

1994 • 236 citations

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.

1996 • 228 citations

Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

2001 • 222 citations

Rat Corticotropin-Releasing Hormone Gene: Sequence and Tissue-Specific Expression*

1987 • 217 citations

Endocrinology of human parturition: a review

1984 • 216 citations

Parathyroid Hormone-Related Protein as a Prohormone: Posttranslational Processing and Receptor Interactions*

1994 • 214 citations

The trophoblast is a component of the innate immune system during pregnancy

2000 • 207 citations

Serum Allopregnanolone Levels in Pregnant Women: Changes during Pregnancy, at Delivery, and in Hypertensive Patients

2000 • 206 citations

CORTICOTROPIN-RELEASING FACTOR-LIKE ACTIVITY IN HUMAN PLACENTAL EXTRACTS

1982 • 203 citations

Trophoblasts express Fas ligand: a proposed mechanism for immune privilege in placenta and maternal invasion

1997 • 203 citations

TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilege

1999 • 191 citations

Patterns of Plasma Corticotropin-Releasing Hormone, Progesterone, Estradiol, and Estriol Change and the Onset of Human Labor

2009 • 189 citations

Elevated levels of umbilical cord plasma corticotropin-releasing hormone in growth-retarded fetuses

1993 • 189 citations

Structure, characterization, and expression of the rat oxytocin receptor gene.

1995 • 188 citations

Neurotransmitters and peptides modulate the release of immunoreactive corticotropin-releasing factor from cultured human placental cells

1989 • 183 citations

The Localization and Distribution of Corticotropin-Releasing Hormone in the Human Placenta and Fetal Membranes throughout Gestation*

1991 • 181 citations

Expression of Fas ligand by human cytotrophoblasts: implications in placentation and fetal survival.

1996 • 181 citations

Alternative splicing of CRH‐R1 receptors in human and mouse skin: identification of new variants and their differential expression

2001 • 179 citations

Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy.

1993 • 179 citations

Toll-like Receptors and their Role in the Trophoblast

2004 • 175 citations

Corticotropin-Releasing Hormone

1988 • 175 citations

Oxytocin Gene Expression in Rat Uterus

1992 • 175 citations

Oxytocin secretion and human parturition: Pulse frequency and duration increase during spontaneous labor in women

1991 • 175 citations

Local stimulation of prostagiandin production by corttcotropin-releasing hormone in human fetal membranes and placenta

1989 • 169 citations

Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa

2000 • 167 citations

Human Plasma β-Endorphin during Pregnancy, Labor, and Delivery*

1981 • 165 citations

Plasma corticotrophin‐releasing factor (CRF) in abnormal pregnancy

1988 • 163 citations

Corticotropin-Releasing Hormone Augments Proinflammatory Cytokine Production from Macrophages In Vitro and in Lipopolysaccharide-Induced Endotoxin Shock in Mice

2002 • 162 citations

Hormonal Regulation of Human Corticotropin-Releasing Hormone Gene Expression: Implications for the Stress Response and Immune/Inflammatory Reaction

1994 • 158 citations

Maternal Corticotropin-Releasing Hormone Is Increased with Impending Preterm Birth

1998 • 157 citations

Elevated maternal plasma corticotropin-releasing hormone levels in pregnancies complicated by preterm labor

1992 • 157 citations

Corticotropin-releasing hormone, stress and human reproduction: an update

2010 • 156 citations

Corticotropin releasing hormone receptors: two decades later

2004 • 156 citations

Plasma Oxytocin Concentrations in Men, Nonpregnant Women, and Pregnant Women before and during Spontaneous Labor*

1981 • 156 citations

Isolation of the human plasma corticotrophin-releasing factor-binding protein

1989 • 150 citations

Immunohistochemical distribution of Toll-like receptor 4 in term and preterm human placentas from normal and complicated pregnancy including chorioamnionitis

2004 • 149 citations

Human Myometrial Gene Expression Before and During Parturition1

2004 • 148 citations

The neurobiology of urocortin

2000 • 147 citations

Role of corticotropin-releasing hormone in onset of labour

1999 • 147 citations

Corticotropin-releasing hormone-induced vasodilatation in the human fetal-placental circulation: involvement of the nitric oxide-cyclic guanosine 3',5'-monophosphate-mediated pathway.

1995 • 145 citations

Characterization of Three Corticotropin-Releasing Factor Receptors in Catfish: A Novel Third Receptor Is Predominantly Expressed in Pituitary and Urophysis*†*The nucleotide sequences reported in this paper have been submitted to the GenBank database with accession numbers cfCRF-R1, AF229359; cfCRF-R2, AF229360; and cfCRF-R3, AF229361.†This work was supported by NIDDK Grant 45020–04A1 from the NIH.

2001 • 140 citations

Expression of Urocortin and Corticotropin-Releasing Factor Receptor Subtypes in the Human Heart

2002 • 140 citations

Human placenta and fetal membranes express human urocortin mRNA and peptide.

1996 • 136 citations

Preterm Birth: Associated Neuroendocrine, Medical, and Behavioral Risk Factors¹

2001 • 135 citations

Ligand requirements of the human corticotropin-releasing factor-binding protein.

1995 • 133 citations

Structure and chromosomal localization of the human antidiuretic hormone receptor gene.

1992 • 133 citations

Apoptosis and Fas Expression in Human Fetal Membranes1

1998 • 132 citations

Control of endometrial oxytocin receptor and uterine response to oxytocin by progesterone and oestradiol in the ewe

1990 • 130 citations

Immunoreactive Corticotropin and Corticotropin Releasing Factor in Human Hypothalamus, Adrenal, Lung Cancer, and Pheochromocytoma*

1984 • 129 citations

Structure of mouse vasopressin and oxytocin genes

1990 • 128 citations

The Impact of Physiological Stimuli on the Expression of Corticotropin-Releasing Hormone (CRH) and Other Neuropeptide Genes

1996 • 128 citations

Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor.

1992 • 127 citations

Isolation and amino acid sequence of urotensin I, a vasoactive and ACTH-releasing neuropeptide, from the carp (Cyprinus carpio) urophysis

1982 • 119 citations

Corticotropin-releasing Hormone in Human Pregnancy and Parturition

1999 • 118 citations

Urocortin, but Not Corticotropin-Releasing Hormone (CRH), Activates the Mitogen-Activated Protein Kinase Signal Transduction Pathway in Human Pregnant Myometrium: An Effect Mediated via R1α and R2β CRH Receptor Subtypes and Stimulation of Gq-Proteins

2000 • 117 citations

Actions of placental and fetal adrenal steroid hormones in primate pregnancy

1995 • 117 citations

A SPECIFIC CARRIER SUBSTANCE FOR HUMAN CORTICOTROPHIN RELEASING FACTOR IN LATE GESTATIONAL MATERNAL PLASMA WHICH COULD MASK THE ACTH‐RELEASING ACTIVITY

1988 • 116 citations

A Novel Spliced Variant of the Type 1 Corticotropin-Releasing Hormone Receptor with a Deletion in the Seventh Transmembrane Domain Present in the Human Pregnant Term Myometrium and Fetal Membranes

1999 • 116 citations

A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor

1997 • 116 citations

Expression of the vasopressin and oxytocin genes in rats occurs in mutually exclusive sets of hypothalamic neurons

1988 • 114 citations

Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure

2002 • 112 citations

Urocortin III, A Brain Neuropeptide of the Corticotropin‐Releasing Hormone Family: Modulation by Stress and Attenuation of Some Anxiety‐Like Behaviours

2004 • 112 citations

Cellulosic Microfibrils: Nascent Stages of Synthesis in a Higher Plant Cell

1976 • 111 citations

HUMAN PLACENTAL AND BOVINE CORPORA LUTEAL OXYTOCIN

1983 • 109 citations

Corticotropin-releasing factor-binding protein is produced by human placenta and intrauterine tissues.

1993 • 109 citations

Human decidua and in vitro decidualized endometrial stromal cells at term contain immunoreactive corticotropin-releasing factor (CRF) and CRF messenger ribonucleic acid.

1992 • 109 citations

The CRH Motoneuron: Differential Peptide Regulation in Neurons with Possible Synaptic, Paracrine, and Endocrine Outputs

1987 • 107 citations

The identification of a human myometrial corticotropin-releasing hormone receptor that increases in affinity during pregnancy.

1993 • 107 citations

Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus.

1992 • 106 citations

Immunoreactive corticotropin-releasing hormone and its binding sites in the rat ovary.

1993 • 106 citations

Corticotropin-releasing factor receptors: An overview

2009 • 105 citations

Corticotropin-releasing hormone-induced vasodilatation in the human fetal placental circulation.

1994 • 105 citations

Characterization of Corticotropin‐releasing Factor Receptor Subtypes^a

1996 • 103 citations

Predicting risk of preterm delivery by second-trimester measurement of maternal plasma corticotropin-releasing hormone and α-fetoprotein concentrations

1999 • 102 citations

The Human Fetal Adrenal: Making Adrenal Androgens for Placental Estrogens

2004 • 101 citations

Crystal structure of the neurophysin—oxytocin complex

1996 • 101 citations

Expression of Fas ligand by human cytotrophoblasts: implications in placentation and fetal survival

1996 • 100 citations

Isolation and Characterization of a Corticotropin-Releasing Hormone-Like Peptide From Human Placenta

1988 • 99 citations

Isolation and amino acid composition of sauvagine. An active polypeptide from methanol extracts of the skin of the South American frog Phyllomedusa sauvagei.

1980 • 96 citations

Corticotropin-Releasing Hormone and Oxytocin Stimulate the Release of Placental Proopiomelanocortin Peptides

1988 • 96 citations

Estrogen stimulates oxytocin gene expression in human chorio-decidua.

1995 • 95 citations

Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein

1995 • 94 citations

Preterm Birth: Associated Neuroendocrine, Medical, and Behavioral Risk Factors

2001 • 94 citations

The Structures of the Mouse and Human Urocortin Genes (Ucn and UCN)

1998 • 93 citations

Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy

1993 • 93 citations

Corticotropin-releasing Hormone Induces Fas Ligand Production and Apoptosis in PC12 Cells via Activation of p38 Mitogen-activated Protein Kinase

2002 • 92 citations

Urocortin 2-Deficient Mice Exhibit Gender-Specific Alterations in Circadian Hypothalamus–Pituitary–Adrenal Axis and Depressive-Like Behavior

2006 • 91 citations

β‐LIPOTROPHIN AND β‐ENDORPHIN PLASMA LEVELS DURING PREGNANCY

1981 • 90 citations

Corticotrophin-releasing factor in human placenta: Localization, concentration and release in vitro

1988 • 90 citations

Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms

1996 • 88 citations

Elevated first-trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery.

1993 • 87 citations

Corticotropin-Releasing Factor and the Urocortins Induce the Expression of TLR4 in Macrophages via Activation of the Transcription Factors PU.1 and AP-1

2006 • 87 citations

Effect of urocortin on ACTH secretion from rat anterior pituitary in vitro and in vivo: comparison with corticotropin-releasing hormone

1998 • 86 citations

Corticotropin-releasing factor and its binding protein: Maternal serum levels in term and preterm deliveries

1996 • 85 citations

The human gene for Oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization

1992 • 83 citations

Oxytocin and the initiation of human parturition

1983 • 83 citations

Demonstration of a Relaxin Receptor and Relaxin-Stimulated Tyrosine Phosphorylation in Human Lower Uterine Segment Fibroblasts*

1998 • 82 citations

A Variant of the Human Corticotropin-Releasing Factor (CRF) Receptor: Cloning, Expression, and Pharmacology

1994 • 82 citations

The corticotrophin-releasing factor-binding protein: an act of several parts

1998 • 82 citations

Urocortin Stimulates Placental Adrenocorticotropin and Prostaglandin Release and Myometrial Contractility in Vitro

1999 • 81 citations

Ca2+ Release by inositol trisphosphate from Ca2+-transporting microsomes derived from uterine sarcoplasmic reticulum

1985 • 81 citations

Evidence for Conservation of the Vasopressin/Oxytocin Superfamily in Annelida

1999 • 81 citations

Mechanisms of Term and Preterm Birth

2002 • 81 citations

Corticotropin-Releasing Hormone System in Human Adipose Tissue

2004 • 80 citations

Urocortins in human reproduction

2004 • 80 citations

Intrauterine infection and the effects of inflammatory mediators on prostaglandin production by myometrial cells from pregnant women

1996 • 80 citations

Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta

1999 • 80 citations

ISOLATION AND AMINO ACID COMPOSITION OF SAUVAGINE

1980 • 79 citations

Parathyroid Hormone-Related Protein Modulates the Effect of Transforming Growth Factor-β on Deoxyribonucleic Acid and Collagen Synthesis in Fetal Rat Bone Cells*

1989 • 78 citations

Corticotrophin-releasing hormone (CRH) interacts with inflammatory prostaglandins and interleukins and affects the decidualization of human endometrial stroma

2000 • 78 citations

Corticotropin-Releasing Hormone (CRH) and Urocortin Act through Type 1 CRH Receptors to Stimulate Dehydroepiandrosterone Sulfate Production in Human Fetal Adrenal Cells

2005 • 78 citations

Oxytocin receptor expression in human term and preterm gestational tissues prior to and following the onset of labour

1999 • 78 citations

Regulation of Corticotropin-Releasing Hormone Type 2 Receptors by Multiple Promoters and Alternative Splicing: Identification of Multiple Splice Variants

2003 • 77 citations

Mechanism of action of interleukin-1β in increasing corticotropin-releasing factor and adrenocorticotropin hormone release from cultured human placental cells

1990 • 77 citations

Fetal and Maternal Oxytocin in Human Parturition

1989 • 77 citations

Identification of a β-endorphin-like peptide in cultured human placental cells

1982 • 75 citations

Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic–pituitary–adrenal axis and induces anxiety-like behavior in adult male rat offspring

2009 • 74 citations

Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells

2002 • 74 citations

The biological activity of the corticotropin-releasing hormone receptor-adenylate cyclase complex in human myometrium is reduced at the end of pregnancy.

1996 • 74 citations

Urocortin, a Newly Identified Corticotropin-Releasing Factor-Related Mammalian Peptide, Stimulates Atrial Natriuretic Peptide and Brain Natriuretic Peptide Secretions from Neonatal Rat Cardiomyocytes

1998 • 74 citations

Human Umbilical Vein Endothelial Cells: A New Source and Potential Target for Corticotropin-Releasing Factor

1999 • 73 citations

A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.

1990 • 73 citations

Effects of Corticotropin-Releasing Hormone and Adrenocorticotropin on Prostaglandin Output by Human Placenta and Fetal Membranes

1990 • 73 citations

Human placenta and fetal membranes express human urocortin mRNA and peptide

1996 • 72 citations

Corticotropin-Releasing Hormone and Urocortin Induce Secretion of Matrix Metalloproteinase-9 (MMP-9) without Change in Tissue Inhibitors of MMP-1 by Cultured Cells from Human Placenta and Fetal Membranes

2005 • 72 citations

Activin A, corticotropin-releasing factor and prostaglandin F2α increase immunoreactive oxytocin release from cultured human placental cells

1996 • 71 citations

Hepatocyte Growth Factor Stimulates Trophoblast Invasion: A Potential Mechanism for Abnormal Placentation in Preeclampsia1

1999 • 71 citations

Elevated mid‐trimester maternal corticotrophin‐releasing hormone levels in pregnancies that delivered before 34 weeks

1999 • 70 citations

A role for noradrenaline in pre‐eclampsia: towards a unifying hypothesis for the pathophysiology

1998 • 70 citations

Human corticotropin releasing hormone gene is located on the long arm of chromosome 8

1988 • 69 citations

Oxytocin: a paracrine hormone in the regulation of parturition?

1998 • 69 citations

Serum relaxin as a potential marker for preterm labour

1992 • 69 citations

Systematic review of randomized controlled trials of misoprostol to prevent postpartum hemorrhage

2002 • 68 citations

Placental Corticotrophin‐Releasing Hormone and its Receptors in Human Pregnancy and Labour: Still a Scientific Enigma

2008 • 67 citations

Vasodilator Actions of Urocortin and Related Peptides in the Human Perfused Placenta in Vitro1

1998 • 67 citations

Gonadal steroid regulation of oxytocin and oxytocin receptor gene expression.

1995 • 66 citations

Urocortin II Is Expressed in Human Pregnant Myometrial Cells and Regulates Myosin Light Chain Phosphorylation: Potential Role of the Type-2 Corticotropin-Releasing Hormone Receptor in the Control of Myometrial Contractility

2003 • 66 citations

Death Receptor Fas/Apo-1/CD95 Expressed by Human Placental Cytotrophoblasts Does Not Mediate Apoptosis1

1999 • 65 citations

PRESENCE OF IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IN RAT TESTIS

1988 • 65 citations

Trophoblast invasion

2004 • 65 citations

Plasma measurements of corticotrophin-releasing hormone-binding protein in normal and abnormal human pregnancy

1993 • 64 citations

Corticotropin-Releasing Hormone Receptor Subtype 1 Is Significantly Up-Regulated at the Time of Labor in the Human Myometrium1

1998 • 64 citations

The Utility of Plasma CRH as a Predictor of Preterm Delivery

2001 • 63 citations

Oxytocin and the timing of parturition. Influence of oxytocin receptor gene expression, oxytocin secretion, and oxytocin-induced prostaglandin F2 alpha and E2 release.

1995 • 62 citations

Surface properties of an amphiphilic peptide hormone and of its analog: corticotropin-releasing factor and sauvagine.

1983 • 61 citations

Association of human corticotropin-releasing hormone to its binding protein in blood may trigger clearance of the complex.

1994 • 61 citations

Urocortins and corticotropin releasing factor type 2 receptors in the hypothalamus and the cardiovascular system

2004 • 59 citations

Preeclampsia Is Associated with Impaired Regulation of the Placental Nitric Oxide-Cyclic Guanosine Monophosphate Pathway by Corticotropin-Releasing Hormone (CRH) and CRH-Related Peptides

2005 • 59 citations

Urocortins of the South African Clawed Frog, Xenopus laevis: Conservation of Structure and Function in Tetrapod Evolution

2005 • 59 citations

Characterization of oxytocin receptors in the uterus and mammary gland.

1977 • 59 citations

Plasma oxytocin and nocturnal uterine activity: Maternal but not fetal concentrations increase progressively during late pregnancy and delivery in rhesus monkeys

1993 • 59 citations

Relationship between maternal and fetal corticotrophin-releasing hormone-41 and ACTH levels in human mid-trimester pregnancy

1987 • 59 citations

The Genomic Structure of the Rat Corticotropin Releasing Factor Receptor

1996 • 58 citations

Accumulation of Cyclooxygenase-2 Gene Transcripts in Uterine Tissues of Pregnant and Parturient Cows: Stimulation by Oxytocin1

1999 • 58 citations

Urocortin in the synovial tissue of patients with rheumatoid arthritis

2001 • 58 citations

Urocortin and Corticotropin-Releasing Factor Receptor Expression in Normal Cycling Human Ovaries¹

2001 • 57 citations

Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes

2006 • 57 citations

Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats

2002 • 57 citations

Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery

1995 • 57 citations

Role of Mitogen-Activated Protein Kinase Pathway in Prostaglandin F2α-Induced Rat Puerperal Uterine Contraction

1997 • 57 citations

Regulation of Oxytocin Receptors and Oxytocin Receptor Signaling

2007 • 57 citations

Estrogen/Hypothalamus-Pituitary-Adrenal Axis Interactions in the Fetus: the Interplay Between Placenta and Fetal Brain

2004 • 56 citations

Production of Pro- and Anti-Inflammatory Cytokines of Human Placental Trophoblasts in Response to Pathogenic Bacteria

2001 • 56 citations

Effect of corticotropin-releasing factor-binding protein on prostaglandin release from cultured maternal decidua and on contractile activity of human myometrium in vitro.

1995 • 56 citations

Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas-mediated apoptosis

1997 • 56 citations

Corticotropin-Releasing Hormone Modulates Human Trophoblast Invasion through Carcinoembryonic Antigen-Related Cell Adhesion Molecule-1 Regulation

2006 • 56 citations

Correlation of nocturnal increase in plasma oxytocin with a decrease in plasma estradiol/progesterone ratio in late pregnancy

1992 • 55 citations

Oxytocin and Oxytocin Receptor Gene Expression in the Reproductive Tract of the Pregnant Cow: Rescue of Luteal Oxytocin Production at Term1

1995 • 55 citations

The role of CRH receptors and their agonists in myometrial contractility and quiescence during pregnancy and labour

2006 • 54 citations

Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin

2007 • 54 citations

Corticotropin-Releasing Hormone and Proopiomelanocortin-Derived Peptides Are Present in Human Myometrium

1998 • 54 citations

Nucleotide sequence of the gene coding for ovine corticotropin-releasing factor and regulation of its mRNA levels by glucocorticoids

1988 • 54 citations

Progesterone receptors A and B differentially modulate corticotropin-releasing hormone gene expression through a cAMP regulatory element

2004 • 52 citations

Relaxing actions of corticotropin‐releasing factor on rat resistance arteries

1993 • 52 citations

Placental Stress Factors and Maternal-Fetal Adaptive Response : The Corticotropin-Releasing Factor Family

2002 • 52 citations

The Role of Mitogen-Activated Protein Kinase in Oxytocin-Induced Contraction of Uterine Smooth Muscle in Pregnant Rat

1996 • 51 citations

Production of pro- and anti-inflammatory cytokines of human placental trophoblasts in response to pathogenic bacteria

2001 • 50 citations

Signal Transduction Characteristics of the Corticotropin-Releasing Hormone Receptors in the Feto-Placental Unit

2000 • 50 citations

“Reproductive” Corticotropin‐Releasing Hormone

2006 • 49 citations

Identification of Immunoreactive Neuropeptide-γ in Human Placenta: Localization, Secretion, and Binding Sites*

1989 • 49 citations

Urocortin interaction with corticotropin-releasing factor (CRF) binding protein (CRF-BP) : a novel mechanism for elevating ‘free’ CRF levels in human brain

1996 • 49 citations

Maternal serum corticotropin‐releasing hormone and ACTH levels as predictive markers of premature labor

2007 • 48 citations

Interleukin-1β Induces Phosphodiesterase 4B2 Expression in Human Myometrial Cells through a Prostaglandin E₂- and Cyclic Adenosine 3′,5′-Monophosphate-Dependent Pathway

2002 • 48 citations

Human CRF2 α and β splice variants: pharmacological characterization using radioligand binding and a luciferase gene expression assay

1999 • 48 citations

The Onset of Labor Alters Corticotropin-Releasing Hormone Type 1 Receptor Variant Expression in Human Myometrium: Putative Role of Interleukin-1β

2007 • 47 citations

Localization and Characterization of Urocortin during Human Pregnancy

2000 • 47 citations

Serial relaxin concentrations in human pregnancy

1979 • 47 citations

5α-dihydroprogesterone formation in human placenta from and 5-pregnan-3β-yl-20-one sulfate

1997 • 47 citations

Parathyroid hormone-related protein as a prohormone: posttranslational processing and receptor interactions

1994 • 46 citations

Differential Regulation of Prostaglandin Production Mediated by Corticotropin-Releasing Hormone Receptor Type 1 and Type 2 in Cultured Human Placental Trophoblasts

2008 • 46 citations

Corticotropin-Releasing Hormone Stimulates Estrogen Biosynthesis in Cultured Human Placental Trophoblasts1

2006 • 46 citations

Cloning and characterization of human urocortin.

1996 • 45 citations

Corticotropin releasing factor-like peptides produce selective dilatation of the dog mesenteric circulation

1984 • 45 citations

Functional Opioid Receptor Sites in Human Placentas*

1988 • 45 citations

Catecholamines in human amniotic fluid

1981 • 45 citations

Neuropeptide Y activates urocortin 1 neurons in the nonpreganglionic Edinger‐Westphal nucleus

2006 • 45 citations

Maternal plasma corticotrophin‐releasing hormone—elevated in preterm labour but unaffected by indomethacin or nylidrin

1991 • 45 citations

Oxytocin and the anterior pituitary gland.

1995 • 44 citations

The Fas/FasL apoptotic pathway is involved in kappa-opioid-induced apoptosis of human endometrial stromal cells

2001 • 44 citations

Corticotropin-releasing hormone inhibits progesterone production in cultured human placental trophoblasts

2006 • 44 citations

Urocortin and Corticotropin-Releasing Factor Receptor Expression in Normal Cycling Human Ovaries

2001 • 43 citations

Identification of urocortin mRNA and peptide in the human endometrium

2002 • 42 citations

Stress and placental resistance measured by Doppler ultrasound in early and mid‐pregnancy

2008 • 42 citations

Polymorphism and genetic mapping of the human oxytocin receptor gene on chromosome 3

1995 • 42 citations

Placental Biogenic Amine Transporters: In Vivo Function, Regulation and Pathobiological Significance

1999 • 42 citations

Effect of Stress and Adrenalectomy on Urocortin II mRNA Expression in the Hypothalamic Paraventricular Nucleus of the Rat

2003 • 41 citations

High Fetal Urocortin Levels at Term and Preterm Labor

2005 • 41 citations

A high-throughput study of gene expression in preterm labor with a subtractive microarray approach

2001 • 41 citations

The oxytocin receptor gene (OXTR) localizes to human chromosome 3p25 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids

1995 • 40 citations

Trophoblast Invasion and Placentation: Molecular Mechanisms and Regulation

2005 • 40 citations

Purification and identification of multiple forms of dynorphin in human placenta

1983 • 40 citations

Corticotropin-releasing hormone: A biochemical predictor of preterm delivery in a pilot randomized trial of the treatment of preterm labor

1998 • 40 citations

Rat Amnion: A Novel Site of Oxytocin Production1

1993 • 40 citations

Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice

2000 • 39 citations

Oxytocin-Stimulated Inositol Phosphate Turnover in Endometrium of Ewes is Influenced by Stage of the Estrous Cycle, Pregnancy, and Intrauterine Infusion of Ovine Conceptus Secretory Proteins1

1990 • 39 citations

Endothelium-dependent and -independent mechanisms of vasorelaxation by corticotropin-releasing factor in pregnant rat uterine artery.

1999 • 39 citations

Structural characterization and localization of corticotropin-releasing factor in testis

1989 • 39 citations

Corticotropin-releasing hormone (CRH) receptors in the mesenteric small arteries of rats resemble the (2)-subtype

1996 • 39 citations

Estrogen Receptor-Mediated Down-Regulation of Corticotropin-Releasing Hormone Gene Expression Is Dependent on a Cyclic Adenosine 3′,5′-Monophosphate Regulatory Element in Human Placental Syncytiotrophoblast Cells

2004 • 38 citations

Progress in the Development of Oxytocin Antagonists for Use in Preterm Labor

1998 • 38 citations

Identification and characterization of a corticotrophin-releasing hormone receptor in human placenta

1995 • 38 citations

The Role of Corticotropin-Releasing Hormone Receptors in Placenta and Fetal Membranes during Human Pregnancy

2001 • 38 citations

Binding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium

1987 • 37 citations

Advances in the design of selective antagonists, potential tocolytics, and radioiodinated ligands for oxytocin receptors.

1995 • 36 citations

The biological activity of the corticotropin-releasing hormone receptor- adenylate cyclase complex in human myometrium is reduced at the end of pregnancy

1996 • 36 citations

Human placental norepinephrine transporter mRNA: Expression and correlation with fetal condition at birth

1997 • 36 citations

Mechanisms of Relaxin‐Mediated Premature Birth

2005 • 36 citations

Lessons from CRH knockout mice

2002 • 35 citations

Immunohistochemical localization of follicle-stimulating hormone, luteinizing hormone, growth hormone, adrenocorticotrophic hormone and prolactin in the human placenta

1986 • 35 citations

Plasma CRH measurement at 16 to 20 weeks' gestation does not predict preterm delivery in women at high-risk for preterm delivery

2005 • 35 citations

Plasma and Amniotic Fluid Immunoreactive Neuropeptide-Y Level Changes during Pregnancy, Labor, and at Parturition

1989 • 34 citations

Localization of the Human CRF2 Receptor to 7p21–p15 by Radiation Hybrid Mapping and FISH Analysis

1997 • 34 citations

Maternal plasma corticotrophin-releasing factor and urocortin levels in post-term pregnancies

2006 • 34 citations

Effects in vitro of progesterone and two 5α‐reduced progestins, 5α‐pregnane‐3,20‐dione and 5α‐pregnane‐3α‐ol‐20‐one, on contracting human myometrium at term

1992 • 34 citations

Investigation of the oxytocin receptor at the molecular level.

1995 • 33 citations

Corticotrophin-releasing hormone-binding protein in human fetal plasma

1995 • 33 citations

Urocortin in pregnancy

1998 • 33 citations

Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes

1999 • 33 citations

Placental Release of Corticotrophin-releasing Hormone Across the Umbilical Circulation of the Human Newborn

1999 • 32 citations

Molecular Endocrinology of the Oxytocin Receptor.

1995 • 32 citations

The Human Corticotropin-Releasing Factor Receptor (CRHR) Gene Maps to Chromosome 17q12-q22

1995 • 32 citations

Human Placental β-Endorphin

1980 • 32 citations

Synthesis and metabolism of oxytocin in late gestation in human decidua.

1995 • 32 citations

Association of human corticotropin-releasing hormone to its binding protein in blood may trigger clearance of the complex

1994 • 31 citations

Corticotropin-Releasing Hormone Receptor Subtype 1 Is Significantly Up-Regulated at the Time of Labor in the Human Myometrium

1998 • 31 citations

De novo biosynthesis of enkephalins and their homologues in the human placenta

1981 • 30 citations

Cord plasma corticotropin-releasing factor-binding protein (CRF-BP) in term and preterm labour

1997 • 29 citations

Basal and Interleukin-1β-Stimulated Prostaglandin Production from Cultured Human Myometrial Cells: Differential Regulation by Corticotropin- Releasing Hormone¹

1999 • 29 citations

Corticotropin-releasing hormone (CRH) and immunotolerance of the fetus

2003 • 29 citations

Localization and ceoncentration of β- and β-lipotrophin in human placenta

1987 • 29 citations

Expression Patterns of CRH, CRH Receptors, and CRH Binding Protein in Human Gestational Tissue at Term

2003 • 28 citations

Beta-endorphin in pregnancy

1984 • 27 citations

Corticotropin-Releasing Factor-Binding Protein: Origins and Possible Functions

1996 • 27 citations

Assignment of disulfide bonds in corticotropin-releasing factor-binding protein.

1994 • 27 citations

Localization of prostaglandin H synthase, prostaglandin dehydrogenase, corticotropin releasing hormone and glucocorticoid receptor in rhesus monkey fetal membranes with labor and in the presence of infection

2004 • 26 citations

Changes in Amniotic Fluid Immunoreactive Corticotropin-Releasing Factor (CRF) and CRF-Binding Protein Levels in Pregnant Women at Term and during Labor¹

1997 • 26 citations

Corticotropin-releasing hormone, its binding protein and receptors in human cervical tissue at preterm and term labor in comparison to non-pregnant state

2006 • 26 citations

Control of Intracellular Signalling by Corticotropin-Releasing Hormone in Human Myometrium

2001 • 26 citations

Attenuation of corticotropin releasing factor-induced hypotension in anesthetized rats with the CRF antagonist, α-helical CRF9–41; Comparison with effect on ACTH release

1992 • 26 citations

Characterization of a Human-Specific Regulator of Placental Corticotropin-Releasing Hormone

1998 • 26 citations

Regulatory mechanism of the arginine vasopressin-enhanced green fluorescent protein fusion gene expression in acute and chronic stress

2009 • 25 citations

Adrenocorticotropin causes vasodilatation in the human fetal-placental circulation.

1996 • 25 citations

Regulation of 15-Hydroxy Prostaglandin Dehydrogenase by Corticotrophin-Releasing Hormone through a Calcium-Dependent Pathway in Human Chorion Trophoblast Cells

2003 • 25 citations

High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension

2006 • 24 citations

CRH-Like Peptides in Human Reproduction

2009 • 23 citations

Urocortin 2 induces tyrosine hydroxylase phosphorylation in PC12 cells

2005 • 22 citations

Differential processing of corticotrophin-releasing hormone by the human placenta and hypothalamus

1988 • 22 citations

Lack of correlation between amniotic fluid and maternal plasma contents of β-endorphin, β-lipotropin, and adrenocorticotropic hormone in normal and pathologic pregnancies

1984 • 22 citations

Regulation of progesterone production in human term trophoblasts in vitro by CRH, ACTH and cortisol (prednisolone)

2005 • 22 citations

Expression of two α2-adrenergic receptor subtypes in human placenta: Evidence from direct binding studies

1994 • 21 citations

Identification, characterization and localization of corticotropin-releasing hormone receptors in human placenta

1996 • 21 citations

Structural domains determining signalling characteristics of the CRH-receptor type 1 variant R1β and response to PKC phosphorylation

2007 • 21 citations

Daily and hourly temporal association between Δ4-androstenedione - induced preterm myometrial contractions and maternal plasma estradiol and oxytocin concentrations in the 0.8 gestation rhesus monkey

1996 • 20 citations

Oxytocin and vasopressin gene expression and RNA splicing patterns in the rat supraoptic nucleus

2008 • 20 citations

Corticotropin releasing hormone concentrations in umbilical cord blood of preterm fetuses.

1992 • 20 citations

Effects of Endotoxin and Macrophage-Related Cytokines on the Contractile Activity of the Gravid Murine Uterus

2003 • 19 citations

Endometrial and myometrial corticotropin-releasing hormone (CRH): its regulation and possible roles

2001 • 19 citations

Corticotropin-Releasing Hormone Receptor Type 1 and Type 2 Mediate Differential Effects on 15-Hydroxy Prostaglandin Dehydrogenase Expression in Cultured Human Chorion Trophoblasts

2007 • 19 citations

Amniotic fluid β-endorphin and α-melanocyte-stimulating hormone immunoreactivity in normal and complicated pregnancies

1982 • 19 citations

Rapid Generation of Stable Cell Lines Expressing Corticotropin-Releasing Hormone Receptor for Drug Discovery

1997 • 18 citations

Urocortin 2 Stimulates Estradiol Secretion From Cultured Human Placental Cells: An Effect Mediated by the Type 2 Corticotrophin-releasing Hormone (CRH) Receptor

2009 • 18 citations

Soluble Corticotropin-Releasing Hormone Receptor 2α Splice Variant Is Efficiently Translated But Not Trafficked for Secretion

2009 • 17 citations

Maternal decidua and fetal membranes contain immunoreactive neuropeptide Y

1993 • 17 citations

Expression of the oxytocin gene, but not the vasopressin gene, in the rat uterus during pregnancy: influence of oestradiol and progesterone

2007 • 17 citations

In vivo effects of corticotropin-releasing factor in pregnant rats

1998 • 16 citations

Reduced Maternal Plasma Urocortin Concentrations and Impaired Uterine Artery Blood Flow at Human Mid Pregnancy

2005 • 15 citations

Corticotropin-Releasing Hormone-Binding Protein and its Possible Role in Neuroendocrinological Research

1997 • 15 citations

Immunoreactive dynorphine in maternal blood, umbilical vein and amniotic fluid

1986 • 15 citations

Placental Endocrine Function

2006 • 14 citations

Fetal Placental Vascular Responses to Corticotropin-Releasing Hormone in Vitro. Effects of Variation in Oxygen Tension

2000 • 14 citations

Expression of human placental D2-dopamine receptor during normal and abnormal pregnancies

1998 • 14 citations

Immunohistochemical profile of the human placenta. Studies on localization of prolactin, human chorionic gonadotropin, human placental lactogen, renin and oxytocin.

1988 • 14 citations

Participation of Maternal and Fetal CRH in Early Phases of Human Implantation: The Role of Antalarmin

2004 • 13 citations

Correlation between amniotic levels of α-MSH, ACTH and β-endorphin in late gestation and labour in normal and complicated pregnancies

1990 • 13 citations

Corticotropin-releasing hormone effects on human pregnant vs. nonpregnant myometrium explants estimated from a mathematical model of uterine contraction

2005 • 13 citations

Immunohistochemical study on oxytocin-like substance in the human placenta.

1984 • 13 citations

Corticotrophin-Releasing Hormone in Lipopolysaccharide-Stimulated Term Fetal Membranes and Amniotic Fluid From Term and Preterm Birth in African Americans and Caucasians

2008 • 13 citations

Effects of urocortin via ion mechanisms or CRF receptors?

2005 • 12 citations

Focus on Primary Care

1998 • 12 citations

Changes in Amniotic Fluid Immunoreactive Corticotropin-Releasing Factor (CRF) and CRF-Binding Protein Levels in Pregnant Women at Term and during Labor

1997 • 11 citations

Corticotropin-Releasing Hormone Increases the Expression of the Prostaglandin E2 Receptor Subtype EP1 in Amnion WISH Cells

2000 • 10 citations

The Prevention of Preterm Labour - Corticotropin Releasing Hormone Type 1 Receptors as a Target for Drug Design and Development

2003 • 10 citations

Detection of immunoreactive human placental oxytocin and its contractile effect on the uterine muscle.

1983 • 10 citations

Modifications of the human urocortin 2 peptide that improve pharmacological properties

2006 • 10 citations

Adrenocorticotropin causes vasodilatation in the human fetal-placental circulation

1996 • 10 citations

The prediction of fetal lung maturity from the surface tension characteristics of amniotic fluid

1975 • 10 citations

Cord Blood Levels of Corticotropin-Releasing Factor

1987 • 9 citations

Changes in β‐Endorphin in Fetal Membranes and Placenta in Normal and Pathological Pregnancies

1990 • 9 citations

Characterization of urocortin in human pregnancy.

2001 • 8 citations

Effects of bPTH fragments (1–34), (3–34) and (7–34) on uterine contraction

1984 • 8 citations

The milk ejecting effect induced by oxytocin during human lactation.

1968 • 6 citations

Tide-Gauge Records: Sea Levels, Land Levels, and Tide Gauges . K. O. Emery and David G. Aubrey. Springer- Verlag, New York, 1991. xiv, 237 pp., illus. $59.

1991 • 6 citations

In pregnancy, corticotropin-releasing-factor in maternal blood and amniotic fluid correlates with the gestational age.

1987 • 6 citations

A Uterine Muscle Contractile Substance Obtained from a Human Placental CDNA Library

1993 • 5 citations

A contribution to the study of milk ejection in women.

1953 • 4 citations

Phorbol Ester Stimulates Corticotropin-Releasing Hormone Gene Promoter Activity Through a cAMP Regulatory Element in Primary Placental Cells

2008 • 4 citations

[Investigations on certain hormonal activities of the placenta].

1955 • 1 citations