Urocortins of the South African Clawed Frog, Xenopus laevis: Conservation of Structure and Function in Tetrapod Evolution

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP

1985 • 39,646 citations

Improved Prediction of Signal Peptides: SignalP 3.0

2004 • 6,335 citations

MEGA2: molecular evolutionary genetics analysis software

2001 • 6,215 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Expression cloning of a human corticotropin-releasing-factor receptor.

1993 • 923 citations

Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor

2001 • 911 citations

Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors

2001 • 877 citations

Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor

2001 • 647 citations

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

1996 • 561 citations

Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39:783-791

1985 • 491 citations

Corticotropin Releasing Factor Receptors and Their Ligand Family

1999 • 421 citations

International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands

2003 • 353 citations

Evolution and Physiology of the Corticotropin-Releasing Factor (CRF) Family of Neuropeptides in Vertebrates

1999 • 282 citations

Complete Amino Acid Sequence of Urotensin I, a Hypotensive and Corticotropin-Releasing Neuropeptide from Catostomus

1982 • 278 citations

Corticotropin-Releasing Factor (CRF) and Endocrine Responses to Stress: CRF Receptors, Binding Protein, and Related Peptides

1997 • 263 citations

The corticotropin-releasing factor family of peptides and CRF receptors: their roles in the regulation of energy balance

2002 • 203 citations

The immune system as the sixth sense

2005 • 190 citations

The role of corticotropin-releasing factor and urocortin in the modulation of ingestive behavior

1999 • 177 citations

Differential Expression of a Cutaneous Corticotropin-Releasing Hormone System

2003 • 175 citations

Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals

2002 • 170 citations

Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart

2000 • 151 citations

AMINO ACID COMPOSITION AND SEQUENCE ANALYSIS OF SAUVAGINE, A NEW ACTIVE PEPTIDE FROM THE SKIN OF PHYLLOMEDUSA SAWAGEI

1981 • 148 citations

Characterization of Three Corticotropin-Releasing Factor Receptors in Catfish: A Novel Third Receptor Is Predominantly Expressed in Pituitary and Urophysis*†*The nucleotide sequences reported in this paper have been submitted to the GenBank database with accession numbers cfCRF-R1, AF229359; cfCRF-R2, AF229360; and cfCRF-R3, AF229361.†This work was supported by NIDDK Grant 45020–04A1 from the NIH.

2001 • 140 citations

Roles of stress hormones in food intake regulation in anuran amphibians throughout the life cycle

2005 • 139 citations

Expression and protective effects of urocortin in cardiac myocytes

1998 • 139 citations

Appetite-Suppressing Effects of Urotensin I and Corticotropin-Releasing Hormone in Goldfish <i>(Carassius auratus)</i>

2001 • 117 citations

Behavioral and neuroendocrine effects of the selective CRF2 receptor agonists urocortin II and urocortin III

2004 • 109 citations

Identification of Two Corticotropin‐Releasing Factor Receptors from Xenopus laevis with High Ligand Selectivity: Unusual Pharmacology of the Type 1 Receptor

1997 • 103 citations

Induction of Apoptosis and CPP32 Expression by Thyroid Hormone in a Myoblastic Cell Line Derived from Tadpole Tail

1997 • 97 citations

Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein

1995 • 94 citations

Effects of urocortin 2 and 3 on motor activity and food intake in rats

2004 • 92 citations

Characterization of the genomic corticotropin-releasing factor (CRF) gene from Xenopus laevis: two members of the CRF family exist in amphibians.

1992 • 90 citations

Comparison of central administration of corticotropin-releasing hormone and urocortin on food intake, conditioned taste aversion, and c-Fos expression☆

2000 • 90 citations

A soluble mouse brain splice variant of type 2α corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity

2005 • 90 citations

Roles of Corticotropin‐Releasing Factor, Neuropeptide Y and Corticosterone in the Regulation of Food Intake In Xenopus laevis

2004 • 89 citations

Evolution of the Corticotropin‐releasing Hormone Signaling System and Its Role in Stress‐induced Phenotypic Plasticity

1999 • 87 citations

Cloning and sequence analysis of cDNA for corticotropin-releasing factor precursor from the teleost fish Catostomus commersoni.

1988 • 77 citations

Ancient evolution of stress-regulating peptides in vertebrates

2004 • 72 citations

Regulation of Corticotropin-Releasing Factor Receptor Type 2β Messenger Ribonucleic Acid in the Rat Cardiovascular System by Urocortin, Glucocorticoids, and Cytokines*

2000 • 69 citations

The Remarkable Conservation of Corticotropin-Releasing Hormone (CRH)-Binding Protein in the Honeybee (Apis mellifera) Dates the CRH System to a Common Ancestor of Insects and Vertebrates

2005 • 68 citations

125I-Antisauvagine-30: a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors

2001 • 66 citations

Urocortins and corticotropin releasing factor type 2 receptors in the hypothalamus and the cardiovascular system

2004 • 59 citations

Corticotropin-Releasing Hormone-Related Peptides and Receptors Emergent Regulators of Cardiovascular Adaptations to Stress

2002 • 55 citations

Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity

2004 • 55 citations

Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences.

2001 • 53 citations

Characterization of the genomic corticotropin-releasing factor (CRF) gene from Xenopus laevis: two members of the CRF family exist in amphibians

1992 • 44 citations

Biochemical characterization and expression analysis of the Xenopus laevis corticotropin-releasing hormone binding protein

2001 • 43 citations

Evidence for the abundant expression of arginine 185 containing human CRF2α receptors and the role of position 185 for receptor-ligand selectivity

2000 • 30 citations