The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication

1987 • 1,050 citations

Human CCAAT-binding proteins have heterologous subunits

1988 • 712 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

The Molecular Genetics of Human Hemoglobin

1984 • 420 citations

Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro

1987 • 386 citations

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

1988 • 313 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.

1987 • 202 citations

A 3′ enhancer is required for temporal and tissue-specific transcriptional activation of the chicken adult β-globin gene

1986 • 192 citations

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

1983 • 190 citations

The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.

1988 • 175 citations

The human β-globin gene contains a downstream developmental specific enhancer

1987 • 167 citations

In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers.

1987 • 149 citations

Regulated gene expression in transfected primary chicken erythrocytes.

1986 • 144 citations

Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene.

1987 • 104 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice.

1987 • 68 citations

Detection of Two Tissue-Specific DNA-Binding Proteins with Affinity for Sites in the Mouse β-Globin Intervening Sequence 2

1988 • 66 citations

A protein factor binding to an octamer motif in the γ-globin promoter disappears upon induction of differentiation and hemoglobin synthesis in K562 cells

1987 • 56 citations

Characterisation of chicken erythroid nuclear proteins which bind to the nuclease hypersensitive regions upstream of the β^A- and β^H-globin genes

1986 • 51 citations

The mechanism of osmotic transfection of avian embryonic erythrocytes: analysis of a system for studying developmental gene expression.

1987 • 37 citations

A novel in vivo transcription assay demonstrates the presence of globin-inducing trans-acting factors in uninduced murine erythroleukemia cells.

1988 • 14 citations