A U1 Small Nuclear Ribonucleoprotein Particle with Altered Specificity Induces Alternative Splicing of an Adenovirus E1A mRNA Precursor

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

1979 • 1,178 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

An unwinding activity that covalently modifies its double-stranded RNA substrate

1988 • 702 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

A mechanism for RNA splicing.

1980 • 553 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins

1988 • 461 citations

THE ROLE OF ANTISENSE RNA IN GENE REGULATION

1986 • 456 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

1984 • 404 citations

The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies.

1984 • 371 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

Nucleotide sequences from the adenovirus-2 genome.

1982 • 345 citations

Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

1986 • 333 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster

1988 • 284 citations

The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein

1988 • 266 citations

U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

1984 • 238 citations

Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing.

1984 • 213 citations

Small Nuclear RNAs: RNA Sequences, Structure, and Modifications

1988 • 202 citations

Formation of the 3′ end of U1 snRNA is directed by a conserved sequence located downstream of the coding region.

1985 • 183 citations

The structure and transcription of four linked rabbit β-like globin genes

1979 • 171 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.

1987 • 142 citations

Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis

1984 • 131 citations

Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons

1987 • 126 citations

Anti-sense RNA as a molecular tool for ] genetic analysis

1985 • 120 citations

Human U2 small nuclear RNA genes contain an upstream enhancer.

1986 • 112 citations

Differential Control of U1 Small Nuclear RNA Expression During Mouse Development

1985 • 112 citations

Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3′ processing of H3 pre-mRNA in the oocyte.

1986 • 96 citations

A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties.

1987 • 95 citations

Small RNAs in the prokaryotes: A growing list of diverse roles

1988 • 52 citations

New U1 RNA species found in Friend SFFV (spleen focus forming virus)-transformed mouse cells.

1985 • 33 citations

Genetic analysis of the role of human U1 snRNA in mRNA splicing: I. Effect of mutations in the highly conserved stem-loop I of U1.

1989 • 27 citations

Structure and expression of a second sea urchin U1 RNA gene repeat

1986 • 25 citations