Functional Expression of Chemokine Receptor CCR5 on CD4⁺T Cells during Virus-Induced Central Nervous System Disease

Chemokines

2000 • 3,773 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus

2000 • 388 citations

Impaired Macrophage Function and Enhanced T Cell-Dependent Immune Response in Mice Lacking CCR5, the Mouse Homologue of the Major HIV-1 Coreceptor

1998 • 252 citations

Cutting Edge: The T Cell Chemoattractant IFN-Inducible Protein 10 Is Essential in Host Defense Against Viral-Induced Neurologic Disease

2000 • 241 citations

CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis

2001 • 240 citations

A Central Role for CD4⁺T Cells and RANTES in Virus-Induced Central Nervous System Inflammation and Demyelination

2000 • 225 citations

Dynamic regulation of alpha- and beta-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease.

1998 • 220 citations

IFN-gamma is required for viral clearance from central nervous system oligodendroglia.

1999 • 220 citations

Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent

2000 • 207 citations

Neutralization of the Chemokine CXCL10 Reduces Inflammatory Cell Invasion and Demyelination and Improves Neurological Function in a Viral Model of Multiple Sclerosis

2001 • 205 citations

IFN-γ Is Required for Viral Clearance from Central Nervous System Oligodendroglia

1999 • 197 citations

Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis

1997 • 192 citations

CD4 and CD8 T Cells Have Redundant But Not Identical Roles in Virus-Induced Demyelination

2000 • 190 citations

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1990 • 189 citations

Dynamic Regulation of α- and β-Chemokine Expression in the Central Nervous System During Mouse Hepatitis Virus-Induced Demyelinating Disease

1998 • 170 citations

Cutting Edge: Role of C-C Chemokine Receptor 5 in Organ-Specific and Innate Immunity toCryptococcus neoformans

1999 • 168 citations

Defects in the generation of IFN-gamma are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1 alpha-, or CCR2-deficient mice.

1999 • 163 citations

MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway

2000 • 160 citations

CCR5 Δ32, matrix metalloproteinase-9 and disease activity in multiple sclerosis

2000 • 154 citations

Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis

1997 • 145 citations

Pathogenesis of mouse hepatitis virus-induced demyelination

1996 • 145 citations

Expression of Mig (Monokine Induced by Interferon-γ) Is Important in T Lymphocyte Recruitment and Host Defense Following Viral Infection of the Central Nervous System

2001 • 141 citations

Defects in the Generation of IFN-γ Are Overcome to Control Infection withLeishmania donovaniin CC Chemokine Receptor (CCR) 5-, Macrophage Inflammatory Protein-1α-, or CCR2-Deficient Mice

1999 • 131 citations

Cytokine-Sensitive Replication of Hepatitis B Virus in Immortalized Mouse Hepatocyte Cultures

2002 • 122 citations

Reduced Macrophage Infiltration and Demyelination in Mice Lacking the Chemokine Receptor CCR5 Following Infection with a Neurotropic Coronavirus

2001 • 116 citations

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis

1995 • 115 citations

Murine coronavirus infection: a paradigm for virus-induced demyelinating disease

1997 • 109 citations

Lack of CCR2 Results in Increased Mortality and Impaired Leukocyte Activation and Trafficking Following Infection of the Central Nervous System with a Neurotropic Coronavirus

2001 • 102 citations

Diversity in MHC class II antigen presentation

2002 • 94 citations

MHV Infection of the CNS: Mechanisms of Immune-Mediated Control

2001 • 93 citations

Increased numbers of CCR5+ interferon-?- and tumor necrosis factor-?-secreting T lymphocytes in multiple sclerosis patients

2000 • 89 citations

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

1993 • 88 citations

Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain

1995 • 88 citations

Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones

1991 • 77 citations

Cutting Edge: CD8 T Cell-Mediated Demyelination Is IFN-γ Dependent in Mice Infected with a Neurotropic Coronavirus

2002 • 77 citations

The Role of T-Cell-Mediated Mechanisms in Virus Infections of the Nervous System

2001 • 72 citations

Preservation of motor function by inhibition of CD8+ virus peptide‐specific T cells in Theiler's virus infection

2001 • 66 citations

The Majority of Infiltrating CD8⁺T Cells in the Central Nervous System of Susceptible SJL/J Mice Infected with Theiler's Virus Are Virus Specific and Fully Functional

2002 • 57 citations

Mouse Hepatitis Virus Infection of the Central Nervous System: Chemokine-Mediated Regulation of Host Defense and Disease

2002 • 55 citations

CD4 T-Cell-Mediated Demyelination Is Increased in the Absence of Gamma Interferon in Mice Infected with Mouse Hepatitis Virus

2002 • 54 citations

Utility of mouse cell line DBT for propagation and assay of mouse hepatitis virus.

1978 • 54 citations

Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain

1993 • 54 citations

Chemokine Expression in the Central Nervous System of Mice with a Viral Disease Resembling Multiple Sclerosis: Roles of CD4⁺and CD8⁺T Cells and Viral Persistence

2002 • 51 citations

Reduced CC Chemokine Receptor (CCR) 1 and CCR5 Surface Expression on Peripheral Blood T Lymphocytes from Patients with Chronic Hepatitis C Infection

2002 • 50 citations

Contributions of CD8+ T Cells and Viral Spread to Demyelinating Disease

2000 • 49 citations

Leukocyte recruitment during pulmonary Cryptococcus neoformans infection

2000 • 43 citations

Successful treatment of established relapsing experimental autoimmune encephalomyelitis in mice with a monoclonal natural autoantibody

1997 • 43 citations

Identification of a CD4+ T Cell Epitope within the M Protein of a Neurotropic Coronavirus

1995 • 42 citations

Interleukin-12- and Gamma Interferon-Dependent Innate Immunity Are Essential and Sufficient for Long-Term Survival of Passively Immunized Mice Infected with Herpes Simplex Virus Type 1

2001 • 39 citations

Myelin-specific tolerance attenuates the progression of a virus-induced demyelinating disease: implications for the treatment of MS

2002 • 39 citations

Gamma interferon expression and major histocompatibility complex induction during measles and vesicular stomatitis virus infections of the brain

1991 • 37 citations

Cellular sources and targets of IFN-γ-mediated protection against viral demyelination and neurological deficits

2002 • 36 citations

Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

2001 • 32 citations

The CXC Chemokines IP-10 and Mig are Essential in Host Defense Following Infection with a Neurotropic Coronavirus

2001 • 21 citations

CD4+ T cell-mediated protection against a lethal outcome of systemic infection with vesicular stomatitis virus requires CD40 ligand expression, but not IFN-γ or IL-4

1999 • 14 citations

Apoptosis of JHMV-Specific CTL in the Cns in the Absence of CD4+ T Cells

1998 • 5 citations

IFN-γ Secreted by Virus-Specific CD8+ T Cells Contribute to CNS Viral Clearance

2001 • 5 citations