Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Immunology Taught by Viruses

1996 • 656 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

1973 • 340 citations

Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies

1986 • 315 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

Mechanism of demyelination in JHM virus encephalomyelitis

1973 • 253 citations

Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in Vivo by monoclonal antibody

1984 • 206 citations

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1990 • 189 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated

1990 • 165 citations

Antigenic relationships of murine coronaviruses: Analysis using monoclonal antibodies to JHM (MHV-4) virus

1983 • 163 citations

Chronic central nervous system demyelination in mice after JHM virus infection

1981 • 158 citations

Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo

1994 • 152 citations

Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis

1996 • 134 citations

Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice

1986 • 128 citations

Dissociation of demyelination and viral clearance in congenitally immunodeficient mice infected with murine coronavirus JHM

1996 • 126 citations

The cellular and molecular pathogenesis of coronaviruses.

1993 • 124 citations

Mouse hepatitis virus-specific cytotoxic T lymphocytes protect from lethal infection without eliminating virus from the central nervous system

1995 • 119 citations

Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats

1995 • 113 citations

Monoclonal antibodies to the matrix (El) glycoprotein of mouse hepatitis virus protect mice from encephalitis

1989 • 113 citations

CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity

1995 • 103 citations

T-cell-mediated clearance of mouse hepatitis virus strain JHM from the central nervous system

1989 • 101 citations

Coronavirus infects and causes demyelination in primate central nervous system

1992 • 100 citations

Lymphocyte‐mediated Cytotoxicity in vitro and in vivo: Mechanisms and Significance

1995 • 95 citations

T cell-dependent IFN-gamma exerts an antiviral effect in the central nervous system but not in peripheral solid organs.

1993 • 88 citations

Murine Coronaviruses: Isolation and Characterization of Two Plaque Morphology Variants of the JHM Neurotropic Strain

1982 • 88 citations

In vivo effects of coronavirus-specific T cell clones: DTH inducer cells prevent a lethal infection but do not inhibit virus replication.

1986 • 86 citations

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM

1991 • 83 citations

The JHM strain of mouse hepatitis virus induces a spike protein-specific Db-restricted cytotoxic T cell response

1996 • 79 citations

Production of mice from a lethal coronavirus infection in the central nervous system by adoptive transfer of virus-specific T cell clones

1991 • 77 citations

Nucleocapsid or spike protein-specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells.

1991 • 76 citations

Recovery from Acute Virus Infection

1988 • 70 citations

Protection from mouse hepatitis virus type 3-induced acute disease by an anti-nucleoprotein monoclonal antibody

1987 • 68 citations

Characterization of the Ld-restricted cytotoxic T-lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein

1993 • 63 citations

Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis

1995 • 48 citations

Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells

1995 • 48 citations

Coronavirus-Induced Demyelination Occurs in the Presence of Virus-Specific Cytotoxic T Cells

1994 • 45 citations

Interaction of immune and central nervous systems: contribution of anti-viral Thy-1+ cells to demyelination induced by coronavirus JHM.

1993 • 45 citations

The role of gamma interferon in infection of susceptible mice with murine coronavirus, MHV-JHM

1991 • 44 citations

Mouse hepatitis virus nucleocapsid protein-specific cytotoxic T lymphocytes are Ld restricted and specific for the carboxy terminus

1992 • 43 citations

FURTHER ULTRASTRUCTURAL OBSERVATIONS OF VIRUS MORPHOGENESIS AND MYELIN PATHOLOGY IN JHM VIRUS ENCEPHALOMYELITIS

1980 • 42 citations

Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus

1992 • 37 citations

Population dynamics of lymphocyte subsets in the central nervous system of rats with different susceptibility to coronavirus-induced demyelinating encephalitis.

1991 • 37 citations

Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone

1994 • 30 citations

Location of Antibody Epitopes within the Mouse Hepatitis Virus Nucleocapsid Protein

1994 • 30 citations

Role of virus-specific CD4+ cytotoxic T cells in recovery from mouse hepatitis virus infection.

1996 • 27 citations

Fas-Based T Cell-Mediated Cytotoxicity

1995 • 20 citations

Neuropathogenicity of mutant strains of mouse hepatitis virus, JHM.

1987 • 3 citations