Murine coronavirus infection: a paradigm for virus-induced demyelinating disease

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

1993 • 782 citations

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

1994 • 570 citations

Cytokine cytotoxicity against oligodendrocytes. Apoptosis induced by lymphotoxin.

1991 • 455 citations

Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.

1994 • 389 citations

Chemokine expression in murine experimental allergic encephalomyelitis

1995 • 363 citations

Multiple sclerosis and human T-cell lymphotropic retroviruses

1985 • 348 citations

Pathogenesis of Demyelination Induced by a Mouse Hepatitis

1973 • 340 citations

Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain.

1986 • 316 citations

Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies

1986 • 315 citations

The Dale E. McFarlin memorial lecture: The immunology of the multiple sclerosis lesion

1994 • 284 citations

Mechanism of demyelination in JHM virus encephalomyelitis

1973 • 253 citations

Adoptive transfer of EAE-like lesions from rats with coronavirus-induced demyelinating encephalomyelitis

1983 • 233 citations

Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells

1995 • 229 citations

Detection of coronavirus RNA and antigen in multiple sclerosis brain

1992 • 210 citations

Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence

1986 • 200 citations

Human coronavirus gene expression in the brains of multiple sclerosis patients

1992 • 188 citations

Two Models for Multiple Sclerosis: Experimental Allergic Encephalomyelitis and Theilerʼs Murine Encephalomyelitis Virus

1996 • 182 citations

Coronavirus Infection Induces H-2 Antigen Expression on Oligodendrocytes and Astrocytes

1986 • 172 citations

Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated

1990 • 165 citations

Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein

1991 • 164 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Sequence analysis reveals extensive polymorphism and evidence of deletions within the E2 glycoprotein gene of several strains of murine hepatitis virus

1989 • 154 citations

The virology of demyelinating diseases

1994 • 149 citations

Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.

1978 • 141 citations

Random nature of coronavirus RNA recombination in the absence of selection pressure

1991 • 134 citations

Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease.

1981 • 129 citations

Activation of Astrocytes in the Spinal Cord of Mice Chronically Infected with a Neurotropic Coronavirus

1995 • 128 citations

Dissociation of demyelination and viral clearance in congenitally immunodeficient mice infected with murine coronavirus JHM

1996 • 126 citations

Myelin basic protein and human coronavirus 229E cross‐reactive T cells in multiple sclerosis

1996 • 117 citations

Purification of the 110-kilodalton glycoprotein receptor for mouse hepatitis virus (MHV)-A59 from mouse liver and identification of a nonfunctional, homologous protein in MHV-resistant SJL/J mice

1990 • 115 citations

Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody

1987 • 104 citations

The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system

1992 • 103 citations

Pathogenesis of Multiple Sclerosis—The Immune Diathesis and the Role of Viruses

1993 • 102 citations

Coronavirus infects and causes demyelination in primate central nervous system

1992 • 100 citations

Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine

1995 • 93 citations

Cytotoxic T Cell–Resistant Variants Are Selected in a Virus-Induced Demyelinating Disease

1996 • 92 citations

Antibodies to coronaviruses OC43 and 229E in multiple sclerosis patients

1982 • 91 citations

Evolution of Mouse Hepatitis Virus (MHV) during Chronic Infection: Quasispecies Nature of the Persisting MHV RNA

1995 • 90 citations

A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus.

1995 • 78 citations

Identification of the spinal cord as a major site of persistence during during chronic infection with a murine coronavirus

1990 • 59 citations

Pathogenesis of Virus-Induced Demyelination

1993 • 57 citations

The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM

1987 • 55 citations

Isolation of herpes simplex virus type 1 during first attack of multiple sclerosis

1989 • 52 citations

Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis

1995 • 48 citations

Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells

1995 • 48 citations

Inducibility of Ia antigen on astrocytes by murine coronavirus JHM is rat strain dependent.

1987 • 42 citations

Sequence analysis of human coronavirus 229E mRNAs 4 and 5: evidence for polymorphism and homology with myelin basic protein

1992 • 27 citations

Susceptibility to Theiler's virus-induced demyelinating disease correlates with astrocyte class II induction and antigen presentation.

1992 • 25 citations

Coronavirus induction of class I major histocompatibility complex expression in murine astrocytes is virus strain specific.

1994 • 25 citations

Coronavirus-induced CNS disease: A model for virus-induced demyelination

1988 • 18 citations

Virus-Induced Autoimmune Disease: Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis

1996 • 17 citations

Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice

1992 • 11 citations

Analysis and Pathogenetic Significance of Class II MHC (Ia) Antigen Induction on Astrocytes During JHM Coronavirus Infection in Rats

1987 • 7 citations

Regulation of MHC Class I and II Antigens on Cerebral Endothelial Cells and Astrocytes Following MHV-4 Infection

1990 • 6 citations

Expression of MHV-A59 Receptor Glycoproteins in Susceptible and Resistant Strains of Mice

1994 • 6 citations

The impact of the intracerebral antibody response on the clinical course of a virus-induced demyelination in a rat model system.

1994 • 5 citations