Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

MHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity

1991 • 474 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Exact prediction of a natural T cell epitope

1991 • 455 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Peptide selection by MHC class I molecules

1991 • 253 citations

The Choice of T‐Cell Epitopes Utilized on a Protein Antigen Depends on Multiple Factors Distant from, as well as at the Determinant Site

1987 • 247 citations

Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis

1983 • 243 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

1986 • 206 citations

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

1998 • 198 citations

Coxsackievirus B3-Induced Myocarditis

1998 • 174 citations

Demyelination induced by Theiler's virus: influence of the H-2 haplotype.

1985 • 157 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.

1984 • 148 citations

Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis

1997 • 145 citations

Theiler's virus infection of beta 2-microglobulin-deficient mice

1993 • 141 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

1994 • 128 citations

Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strains map near the T cell beta-chain constant gene on chromosome 6.

1987 • 127 citations

Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin.

1993 • 116 citations

Class I‐deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination

1993 • 112 citations

Perforin-Dependent Neurologic Injury in a Viral Model of Multiple Sclerosis

1998 • 111 citations

The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice

1992 • 104 citations

Purification of Theiler's Murine Encephalomyelitis Virus and Analysis of the Structural Virion Polypeptides: Correlation of the Polypeptide Profile with Virulence

1980 • 101 citations

Theiler's virus antigen detected in mouse spinal cord 2½ years after infection

1984 • 99 citations

Evidence for CD8+ T-cell immunity to murine rotavirus in the absence of perforin, fas, and gamma interferon

1997 • 95 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice.

1994 • 93 citations

Theiler’s Virus Infection of Perforin-Deficient Mice

1998 • 88 citations

The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system

1992 • 87 citations

Perforin is present only in normal activated Lyt2+ T lymphocytes and not in L3T4+ cells, but the serine protease granzyme A is made by both subsets.

1987 • 86 citations

Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease.

1995 • 76 citations

An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence

1997 • 72 citations

A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1(233-244).

1994 • 71 citations

Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment

1987 • 70 citations

Flow cytometric and functional analyses of central nervous system-infiltrating cells in SJL/J mice with Theiler's virus-induced demyelinating disease. Evidence for a CD4+ T cell-mediated pathology.

1996 • 68 citations

Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice

1997 • 63 citations

Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue

1997 • 61 citations

Role of Individual T-Cell Epitopes of Theiler’s Virus in the Pathogenesis of Demyelination Correlates with the Ability To Induce a Th1 Response

1998 • 58 citations

Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice

1990 • 52 citations

Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice

1995 • 47 citations

Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

1990 • 46 citations

Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease.

1991 • 39 citations

The relationship between viral RNA, myelin-specific mRNAs, and demyelination in central nervous system disease during Theiler's virus infection.

1990 • 36 citations

Treatment with lipopolysaccharide enhances the pathogenicity of a low-pathogenic variant of Theiler's murine encephalomyelitis virus

1996 • 26 citations

Major linear antibody epitopes and capsid proteins differentially induce protective immunity against Theiler's virus-induced demyelinating disease

1997 • 23 citations

Association between susceptibility to Theiler's virus-induced demyelination and T-cell receptor Jbeta1-Cbeta1 polymorphism rather than Vbeta deletion

1997 • 20 citations

Immune mechanisms of Theiler's virus-induced demyelination

1999 • 16 citations

A new model of persistent viral infection with primary demyelination.

1977 • 12 citations