CD4 and CD8 T Cells Have Redundant But Not Identical Roles in Virus-Induced Demyelination

Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

1998 • 344 citations

Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies

1986 • 315 citations

Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

1999 • 259 citations

Mechanism of demyelination in JHM virus encephalomyelitis

1973 • 253 citations

Persistent Viral Infections

1996 • 249 citations

A Central Role for CD4⁺T Cells and RANTES in Virus-Induced Central Nervous System Inflammation and Demyelination

2000 • 225 citations

IFN-gamma is required for viral clearance from central nervous system oligodendroglia.

1999 • 220 citations

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

1998 • 198 citations

IFN-γ Is Required for Viral Clearance from Central Nervous System Oligodendroglia

1999 • 197 citations

Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells

1990 • 189 citations

Inverted Immunodominance and Impaired Cytolytic Function of CD8+ T Cells During Viral Persistence in the Central Nervous System

1999 • 171 citations

Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated

1990 • 165 citations

CTL Effector Function Within the Central Nervous System Requires CD4+ T Cells

1998 • 161 citations

Indictment of the microglia as the villain in multiple sclerosis

1997 • 148 citations

Pathogenesis of mouse hepatitis virus-induced demyelination

1996 • 145 citations

Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis

1997 • 145 citations

Macrophage Infiltration, but Not Apoptosis, Is Correlated with Immune-Mediated Demyelination following Murine Infection with a Neurotropic Coronavirus

1999 • 133 citations

Role of macrophages during Theiler's virus infection

1997 • 130 citations

Dissociation of demyelination and viral clearance in congenitally immunodeficient mice infected with murine coronavirus JHM

1996 • 126 citations

CD4⁺and CD8⁺T Cells Make Discrete Contributions to Demyelination and Neurologic Disease in a Viral Model of Multiple Sclerosis

1998 • 117 citations

Late onset, symptomatic, demyelinating encephalomyelitis in mice infected with MHV-JHM in the presence of maternal antibody

1987 • 104 citations

CD8+ T-cell epitopes within the surface glycoprotein of a neurotropic coronavirus and correlation with pathogenicity

1995 • 103 citations

Perforin-deficient CD8+ T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD95 and IFN-gamma but requires TNF-alpha.

1998 • 93 citations

Perforin-Deficient CD8+ T Cells Provide Immunity to Listeria monocytogenes by a Mechanism That Is Independent of CD95 and IFN-γ but Requires TNF-α

1998 • 83 citations

The JHM strain of mouse hepatitis virus induces a spike protein-specific Db-restricted cytotoxic T cell response

1996 • 79 citations

Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects.

1998 • 79 citations

Axonal Damage Is T Cell Mediated and Occurs Concomitantly with Demyelination in Mice Infected with a Neurotropic Coronavirus

2001 • 79 citations

Contributions of Fas-Fas Ligand Interactions to the Pathogenesis of Mouse Hepatitis Virus in the Central Nervous System

2000 • 71 citations

Pathogenesis of Coronavirus-Induced Infections

1998 • 67 citations

Depletion of Blood-Borne Macrophages Does Not Reduce Demyelination in Mice Infected with a Neurotropic Coronavirus

1999 • 54 citations

Selection of CTL Escape Mutants in Mice Infected with a Neurotropic Coronavirus: Quantitative Estimate of TCR Diversity in the Infected Central Nervous System

1999 • 49 citations

Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis

1995 • 48 citations

Identification of a CD4+ T Cell Epitope within the M Protein of a Neurotropic Coronavirus

1995 • 42 citations

CD4 and CD8 T cells are not major effectors of mouse hepatitis virus A59-induced demyelinating disease

1997 • 39 citations

Coronavirus-Induced Demyelination Occurs in the Absence of Inducible Nitric Oxide Synthase

2000 • 36 citations

Inhibition of nitric oxide synthase-2 reduces the severity of mouse hepatitis virus-induced demyelination: implications for NOS2/NO regulation of chemokine expression and inflammation

1999 • 35 citations

Murine coronavirus-induced encephalomyelitides in rats: Analysis of immunoglobulins and virus-specific antibodies in serum and cerebrospinal fluid

1986 • 33 citations

Antigen Specificity of CD4 T Cell Response in the Central Nervous System of Mice Infected with Mouse Hepatitis Virus

1997 • 31 citations

Immune Response to the Immunodominant Epitope of Mouse Hepatitis Virus Is Polyclonal, but Functionally Monospecific in C57Bl/6 Mice

1999 • 24 citations

Modulation of acute coronavirus-induced encephalomyelitis in γ-irradiated rats by transfer of naive lymphocyte subsets before infection

1999 • 5 citations

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