Central Tolerance of T Cells

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

The immune system evolved to discriminate infectious nonself from noninfectious self

1992 • 1,324 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Negative selection of lymphocytes

1994 • 810 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Genes and Antibodies

1959 • 675 citations

Positive selection of lymphocytes

1994 • 563 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

A Modification of Jerne's Theory of Antibody Production using the Concept of Clonal Selection.

1957 • 493 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

T Cell Selection in the Thymus

1988 • 405 citations

The Molecular Basis of Allorecognition

1993 • 398 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.

1982 • 321 citations

Homing of naive, memory and effector lymphocytes

1993 • 295 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

1983 • 285 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

EVIDENCE FOR A BLOOD-THYMUS BARRIER USING ELECTRON-OPAQUE TRACERS

1972 • 258 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

T-Cell Differentiation is Influenced by Thymic Microenvironments

1991 • 239 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Transgenic mouse mammary tumor virus superantigen expression prevents viral infection

1992 • 223 citations

Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer.

1982 • 217 citations

Intrathymic and extrathymic clonal deletion of T cells

1995 • 201 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus.

1993 • 168 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

Experimental autoimmune prostatitis after neonatal thymectomy in the mouse.

1985 • 161 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

Two signals are required for negative selection of CD4+CD8+ thymocytes.

1993 • 143 citations

Association of immunity and tolerance to host H-2 determinants in irradiated F1 hybrid mice reconstituted with bone marrow cells from one parental strain.

1975 • 140 citations

Autoimmunity and Autoimmune Diseases

1989 • 137 citations

T-cell subsets in autoimmunity

1993 • 129 citations

Tolerance induction by thymic medullary epithelium.

1992 • 121 citations

Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease.

1990 • 120 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

Cyclosporine-induced autoimmunity. Conditions for expressing disease, requirement for intact thymus, and potency estimates of autoimmune lymphocytes in drug-treated rats.

1986 • 118 citations

Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology.

1987 • 117 citations

Two subsets of epithelial cells in the thymic medulla.

1992 • 116 citations

Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

1990 • 112 citations

Thymus epithelium induces tissue-specific tolerance.

1993 • 111 citations

Slow bacterial infections or autoimmunity?

1992 • 109 citations

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.

1989 • 108 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

T-cell differentiation in thymus organ cultures.

1990 • 100 citations

Immune responses of thymusf/ymphocyte embryonic chimeras: studies on tolerance and major histocompatibility complex restriction in Xenopus

1985 • 90 citations

Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages.

1989 • 90 citations

Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses

1994 • 80 citations

Tolerogenicity of thymic epithelium

1990 • 74 citations

Signaling for death of lymphoid cells

1993 • 71 citations

The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier?

1988 • 67 citations

Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression.

1994 • 65 citations

Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat

1987 • 58 citations

T-cell tolerance

1993 • 55 citations

Functional recognition of in vivo processed self antigen

1994 • 53 citations

Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide.

1992 • 50 citations

Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.

1983 • 49 citations

T Cell Function in Bone Marrow Chimeras; Absence of Host‐Reactive T Cells and Cooperation of Helper T Cells across Allogeneic Barriers

1976 • 49 citations

A peripheral mechanism preserves self-tolerance to a secreted protein in transgenic mice.

1990 • 41 citations

The role of thymic epithelium in the acquisition of tolerance

1990 • 37 citations

Differential expression of Mtv loci in MHC class II-positive thymic stromal cells.

1994 • 33 citations

Tolerance of CD8+ T cells developing in parent-->F1 chimeras prepared with supralethal irradiation: step-wise induction of tolerance in the intrathymic and extrathymic environments.

1993 • 32 citations

Thymic epithelium induces full tolerance to skin and heart but not to B lymphocyte grafts

1995 • 29 citations

Expression of two structurally identical viral superantigens results in thymic elimination at distinct developmental stages.

1994 • 24 citations

Requirement of a second signal from antigen presenting cells in the clonal deletion of immature T cells

1994 • 23 citations

The Thymus and T‐Cell Tolerancea

1993 • 22 citations

Role of the thymus in the generation of skin-homing αβ and γδ virgin T cells

1995 • 13 citations

T Cell Tolerance and Self/Nonself Discrimination

1993 • 12 citations