Insulin-Like Growth Factor Receptors

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts.

1977 • 580 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

A hypothesis for I-cell disease: Defective hydrolases that do not enter lysosomes

1972 • 446 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

1988 • 363 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Expression and characterization of a functional human insulin-like growth factor I receptor.

1988 • 313 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.

1989 • 276 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis

1989 • 272 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Insulin-like Growth Factor I Receptor β-Subunit Heterogeneity

1989 • 259 citations

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 • 247 citations

The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells.

1988 • 244 citations

An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

1987 • 237 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

Differential signalling potential of insulin- and IGF-1-receptor cytoplasmic domains.

1989 • 225 citations

Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes

1987 • 224 citations

Primary Structure of a Putative Receptor for a Ligand of the Insulin Family

1989 • 224 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Insulin as a Potent, Specific Growth Factor in a Rat Hepatoma Cell Line

1981 • 221 citations

Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

1988 • 211 citations

Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor.

1988 • 210 citations

Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

1985 • 203 citations

The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.

1988 • 199 citations

Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors

1989 • 196 citations

Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.

1987 • 195 citations

Ligand interactions of the cation-independent mannose 6-phosphate receptor

1989 • 194 citations

Purification and characterization of a cation-dependent mannose 6-phosphate receptor from murine P388D1 macrophages and bovine liver.

1985 • 193 citations

Insulin-like growth factor II stimulates calcium influx in competent BALB/c 3T3 cells primed with epidermal growth factor. Characteristics of calcium influx and involvement of GTP-binding protein.

1987 • 192 citations

Biochemical evidence that the type II insulin-like growth factor receptor is identical to the cation-independent mannose 6-phosphate receptor.

1988 • 190 citations

Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II.

1989 • 188 citations

Insulin induction of Xenopus laevis oocyte maturation is inhibited by monoclonal antibody against p21 ras proteins.

1987 • 183 citations

Nucleotide sequence of a growth-related mRNA encoding a member of the prolactin-growth hormone family.

1984 • 179 citations

Possible Direct Linkage of Insulin-like Growth Factor-II Receptor with Guanine Nucleotide-binding Proteins

1989 • 169 citations

Evidence from Monoclonal Antibody Studies that Insulin Stimulates Deoxyribonucleic Acid Synthesis through the Type I Somatomedin Receptor*

1985 • 160 citations

An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture

1987 • 155 citations

Identification of proliferin mRNA and protein in mouse placenta.

1985 • 155 citations

46 kd mannose 6-phosphate receptor: Cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor

1987 • 150 citations

The receptor for insulin-like growth factor II mediates an insulin-like response.

1987 • 145 citations

Chicken and Xenopus Mannose 6-Phosphate Receptors Fail to Bind Insulin-like Growth Factor II

1989 • 137 citations

Interactions of recombinant and platelet transforming growth factor-β1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor

1989 • 127 citations

Is movement of mannose 6-phosphate-specific receptor triggered by binding of lysosomal enzymes?

1987 • 123 citations

IGF-2 stimulated growth mediated by the somatomedin type 2 receptor

1987 • 121 citations

Characterization of receptor tyrosine-specific protein kinases by the use of inhibitors. Staurosporine is a 100-times more potein inhibitor of insulin receptor than IGF-I receptor

1988 • 121 citations

Interactions of Cathepsin-D and Insulin-Like Growth Factor-II (IGF-II) on the IGF-II/Mannose-6-Phosphate Receptor in Human Breast CancerCells and Possible Consequences on Mitogenic Activity of IGF-II

1990 • 119 citations

The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II

1989 • 110 citations

Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.

1990 • 108 citations

The Type II Insulin-Like Growth Factor Receptor Does Not Mediate Deoxyribonucleic Acid Synthesis in Human Fibroblasts*

1987 • 108 citations

Insulin-like growth factor II binding to the type I somatomedin receptor. Evidence for two high affinity binding sites.

1986 • 104 citations

Effect of an anti-insulin-like growth factor I receptor antibody on insulin-like growth factor II stimulation of DNA synthesis in human fibroblasts

1986 • 98 citations

Assembly of insulin/insulin-like growth factor-1 hybrid receptors in vitro

1989 • 98 citations

Insulin-like growth factor-II (IGF-II) inhibits both the cellular uptake of β-galactosidase and the binding of β-galactosidase to purified IGF-II/mannose 6-phosphate receptor

1989 • 94 citations

Mannose 6-phosphate/insulin-like growth factor II receptor: Distinct binding sites for mannose 6-phosphate and insulin-like growth factor II

1988 • 91 citations

Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor

1987 • 89 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand.

1986 • 87 citations

Insulin and insulinlike growth factor 1 (IGF-1) receptors during central nervous system development: expression of two immunologically distinct IGF-1 receptor beta subunits.

1989 • 84 citations

Purification of an insulin-like growth factor II receptor from rat chondrosarcoma cells.

1983 • 78 citations

Mannose 6-phosphate/insulin like growth factor II receptor: The two types of ligands bind simultaneously to one receptor at different sites

1988 • 77 citations

A Novel Fetal Insulin-Like Growth Factor (IGF) I Receptor

1989 • 76 citations

Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.

1989 • 76 citations

Thyroglobulin, the major and obligatory exportable protein of thyroid follicle cells, carries the lysosomal recognition marker mannose-6-phosphate.

1987 • 75 citations

Insulin-like growth factor II stimulates production of inositol trisphosphate in proximal tubular basolateral membranes from canine kidney.

1988 • 75 citations

Activation of a calcium-permeable cation channel by insulin-like growth factor II in BALB/c 3T3 cells

1988 • 73 citations

Evidence that type II insulin-like growth factor receptor is coupled to calcium gating system

1988 • 72 citations

Purification of the type II insulin-like growth factor receptor from rat placenta.

1983 • 71 citations

Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells.

1990 • 66 citations

Activation of glucose uptake by insulin and insulin-like growth factor I in Xenopus oocytes.

1989 • 63 citations

Mannose 6-phosphate potentiates insulin-like growth factor II-stimulated inositol trisphosphate production in proximal tubular basolateral membranes

1989 • 63 citations

Interaction of nuclear factors with the upstream region of the alpha-subunit gene of chicken muscle acetylcholine receptor: variations with muscle differentiation and denervation.

1989 • 59 citations

Expression and characterization of a functional human insulin like growth factor-I receptor. J Biol Chem 263:11486-11492

1988 • 57 citations

Identification of an alternate type I insulin-like growth factor receptor β subunit mRNA transcript

1989 • 57 citations

Purification and Immunological Characterization of the Rat Liver Insulin-Like Growth Factor-II Receptor

1987 • 57 citations

Insulin promotes the growth of F9 embryonal carcinoma cells apparently by acting through its own receptor

1982 • 55 citations

Insulin‐like growth factor I receptors on mouse neuroblastoma cells

1988 • 53 citations

Possible Involvement of Normal p21 H-ras in the Insulin/Insulinlike Growth Factor 1 Signal Transduction Pathway

1989 • 52 citations

The Metabolic and Mitogenic Effects of Both Insulin and Insulin-like Growth Factor Are Enhanced by Transfection of Insulin Receptors into NIH3T3 Fibroblasts

1989 • 51 citations

Transforming growth factor-beta: new chemical forms and new biological roles.

1988 • 50 citations

The structural basis for insulin-like growth factor I receptor high affinity binding.

1988 • 50 citations

Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors.

1990 • 50 citations

β‐Galactosidase decreases the binding affinity of the insulin‐like‐growth‐factor‐II/mannose‐6‐phosphate receptor for insulin‐like‐growth‐factor II

1990 • 50 citations

Multiplication-stimulating activity-induced alkalinization of canine renal proximal tubular cells.

1986 • 49 citations

Insulin and insulin-like growth factor 1 stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein in 3T3-L1 adipocytes

1988 • 48 citations

Pertussis toxin inhibits the action of insulin-like growth factor-I

1987 • 46 citations

Insulin-like growth factor II increases cytoplasmic free calcium in competent Balbc 3T3 cells treated with epidermal growth factor

1987 • 46 citations

Polylysine specifically activates the insulin-dependent insulin receptor protein kinase

1989 • 46 citations

Insulin Stimulation of Aminoisobutyric Acid Transport in Human Skin Fibroblasts Is Mediated Through Both Insulin and Type I Insulin-Like Growth Factor Receptors*

1986 • 45 citations

Functional properties of an isolated .alpha..beta. heterodimeric human placenta insulin-like growth factor 1 receptor complex

1988 • 42 citations

Insulin-like growth factors I and II stimulate endocytosis but do not affect sorting of lysosomal enzymes in human fibroblasts.

1990 • 42 citations

Binding of insulin-like growth Factor ii and multiplication-stimulating activity-stimulated phosphorylation in basolateral membranes from dog kidney.

1984 • 41 citations

Insulin-receptor phosphotyrosyl-protein phosphatases

1988 • 41 citations

Mannose 6-phosphate-containing peptides activate phospholipase C in proximal tubular basolateral membranes from canine kidney.

1990 • 37 citations

Delineation of atypical insulin receptors from classical insulin and type I insulin-like growth factor receptors in human placenta

1989 • 36 citations

The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells.

1989 • 36 citations

Insulin-like growth factor I stimulates inositol phosphate accumulation, a rise in cytoplasmic free calcium, and proliferation in cultured porcine thyroid cells

1989 • 34 citations

Specificity of tyrosine protein kinases of the structurally related receptors for insulin and insulin-like growth factor I: Tyr-containing synthetic polymers as specific inhibitors or substrates

1988 • 34 citations

Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes

1989 • 33 citations

Secretion of Proliferin*

1987 • 33 citations

Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway.

1989 • 28 citations

Transforming ras proteins accelerate hormone-induced maturation and stimulate cyclic AMP phosphodiesterase in Xenopus oocytes.

1990 • 27 citations

Mannose 6-phosphate increases the affinity of its cation-independent receptor for insulin-like growth factor II by displacing inhibitory endogenous ligands

1988 • 24 citations

Insulin-like growth factor binding to the atypical insulin receptors of a human lymphoid-derived cell line (IM-9)

1990 • 24 citations

Mannose‐6‐phosphate stimulates proliferation of neuronal precursor cells

1990 • 21 citations

Effects of Mannose-6-Phosphate on Receptor-Mediated Endocytosis of Insulin-Like Growth Factor-II*

1990 • 21 citations

Parallel effects of insulin-like growth factor-II and insulin on glucose metabolism of developing mouse embryonic limb buds in culture

1988 • 19 citations

IGF-1-dependent subunit communication of the IGF-1 holoreceptor: interactions between .alpha..beta. heterodimeric receptor halves

1989 • 18 citations

ENDOCYTOSIS OF RECEPTOR-BOUND INSULIN-LIKE GROWTH FACTOR II IS ENHANCED BY MANNOSE-6-PHOSPHATE IN IM9 CELLS

1988 • 14 citations

Characterization of an endogenous substrate related to insulin and insulin-like growth factor-I receptors in lizard brain.

1987 • 13 citations

Studies on the cell‐cycle dependency of the actions of insulin‐like growth factor‐I in Balb/c 3T3 cells

1990 • 13 citations

Expression of Atypical and Classical Insulin Receptors in Chinese Hamster Ovary Cells Transfected with Cloned cDNA for the Human Insulin Receptor*

1990 • 10 citations

pp-120: A common endogenous substrate for insulin and IGF-1 receptor-associated tyrosine kinase activity in the highly malignant AS-30D rat hepatoma cells

1989 • 9 citations