Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

2002 • 1,176 citations

In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination

2004 • 905 citations

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

2002 • 785 citations

Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen

2004 • 782 citations

Prostaglandin D ₂ as a Mediator of Allergic Asthma

2000 • 731 citations

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma

2005 • 610 citations

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

2001 • 578 citations

Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes

2000 • 554 citations

Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation

2000 • 513 citations

Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent

2005 • 507 citations

Inaugural Article : avoiding horror autotoxicus. The importance of dendritic cells in peripheral T cell tolerance

2002 • 448 citations

Selective Expression of a Novel Surface Molecule by Human Th2 Cells In Vivo

1999 • 383 citations

Taking our breath away: dendritic cells in the pathogenesis of asthma

2003 • 340 citations

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

1995 • 332 citations

Induction of T helper type 1–like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

2004 • 313 citations

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.

1988 • 285 citations

Evidence for Elevated Levels of Histamine, Prostaglandin D₂, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma

1990 • 254 citations

Pivotal roles of the parasite PGD₂ synthase and of the host D prostanoid receptor 1 in schistosome immune evasion

2003 • 251 citations

Immune regulation by histamine

2002 • 234 citations

Alveolar Macrophage in the Driver's Seat

2006 • 229 citations

Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

2005 • 226 citations

Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice

2002 • 225 citations

The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues.

1989 • 221 citations

T-cell trafficking in asthma: lipid mediators grease the way

2004 • 218 citations

Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse

2005 • 213 citations

Emerging roles of DP and CRTH2 in allergic inflammation

2006 • 207 citations

Allergic lung responses are increased in prostaglandin H synthase–deficient mice

1999 • 204 citations

Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma

2003 • 192 citations

Prostaglandin D2 Inhibits Airway Dendritic Cell Migration and Function in Steady State Conditions by Selective Activation of the D Prostanoid Receptor 1

2003 • 184 citations

A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma

2004 • 180 citations

Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases

2006 • 177 citations

Prostaglandin D2 Affects the Maturation of Human Monocyte-Derived Dendritic Cells: Consequence on the Polarization of Naive Th Cells

2003 • 145 citations

Selective Cyclooxygenase-1 and -2 Inhibitors Each Increase Allergic Inflammation and Airway Hyperresponsiveness in Mice

2002 • 120 citations

Prostaglandin D2 Reinforces Th2 Type Inflammatory Responses of Airways to Low-dose Antigen through Bronchial Expression of Macrophage-derived Chemokine

2003 • 116 citations

Prostaglandin D₂-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor

2004 • 110 citations

Uteroglobin Represses Allergen-induced Inflammatory Response by Blocking PGD2 Receptor–mediated Functions

2004 • 98 citations

Cutting Edge: Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells Plays a Restricting Role on IL-5 Production and Eosinophil Recruitment

2005 • 83 citations

Prostaglandin D₂ inhibits the production of interleukin‐12 in murine dendritic cells through multiple signaling pathways

2003 • 57 citations

Evaluation of Selective Prostaglandin E₂(PGE₂) Receptor Agonists as Therapeutic Agents for the Treatment of Asthma

2005 • 38 citations